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Literature DB >> 33472028

A platform for experimental precision medicine: The extended BXD mouse family.

David G Ashbrook¹, Danny Arends², Pjotr Prins³, Megan K Mulligan³, Suheeta Roy³, Evan G Williams⁴, Cathleen M Lutz⁵, Alicia Valenzuela⁵, Casey J Bohl³, Jesse F Ingels³, Melinda S McCarty³, Arthur G Centeno³, Reinmar Hager⁶, Johan Auwerx⁷, Lu Lu⁸, Robert W Williams⁹.

Abstract

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for predictive validation. BXDs are a unique core resource for the field of experimental precision medicine.

Entities: Chemical

Keywords: GXE; complex trait; gene mapping; personalized medicine; power calculation; recombinant inbred strains; systems biology; systems genetics

Mesh：

Year: 2021 PMID： 33472028 PMCID： PMC7979527 DOI： 10.1016/j.cels.2020.12.002

Source DB: PubMed Journal: Cell Syst ISSN： 2405-4712 Impact factor: 10.304

137 in total

1. WebQTL: web-based complex trait analysis.

Authors: Jintao Wang; Robert W Williams; Kenneth F Manly
Journal: Neuroinformatics Date: 2003

2. Quantitative trait mapping in a diallel cross of recombinant inbred lines.

Authors: Shirng-Wern Tsaih; Lu Lu; David C Airey; Robert W Williams; Gary A Churchill
Journal: Mamm Genome Date: 2005-05 Impact factor: 2.957

3. Inbreeding and Linkage.

Authors: J B Haldane; C H Waddington
Journal: Genetics Date: 1931-07 Impact factor: 4.562

Review 4. Informatics resources for the Collaborative Cross and related mouse populations.

Authors: Andrew P Morgan; Catherine E Welsh
Journal: Mamm Genome Date: 2015-07-02 Impact factor: 2.957

5. GeneNetwork: A Toolbox for Systems Genetics.

Authors: Megan K Mulligan; Khyobeni Mozhui; Pjotr Prins; Robert W Williams
Journal: Methods Mol Biol Date: 2017

6. Predictive, preventive, personalized and participatory medicine: back to the future.

Authors: Charles Auffray; Dominique Charron; Leroy Hood
Journal: Genome Med Date: 2010-08-26 Impact factor: 11.117

7. Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains.

Authors: John T Heiker; Anne Kunath; Joanna Kosacka; Gesine Flehmig; Anja Knigge; Matthias Kern; Michael Stumvoll; Peter Kovacs; Matthias Blüher; Nora Klöting
Journal: Physiol Genomics Date: 2014-04-01 Impact factor: 3.107

8. Linking traits based on their shared molecular mechanisms.

Authors: Yael Oren; Aharon Nachshon; Amit Frishberg; Roni Wilentzik; Irit Gat-Viks
Journal: Elife Date: 2015-03-17 Impact factor: 8.140

9. Defining the role of common variation in the genomic and biological architecture of adult human height.

Authors: Andrew R Wood; Tonu Esko; Jian Yang; Sailaja Vedantam; Tune H Pers; Stefan Gustafsson; Audrey Y Chu; Karol Estrada; Jian'an Luan; Zoltán Kutalik; Najaf Amin; Martin L Buchkovich; Damien C Croteau-Chonka; Felix R Day; Yanan Duan; Tove Fall; Rudolf Fehrmann; Teresa Ferreira; Anne U Jackson; Juha Karjalainen; Ken Sin Lo; Adam E Locke; Reedik Mägi; Evelin Mihailov; Eleonora Porcu; Joshua C Randall; André Scherag; Anna A E Vinkhuyzen; Harm-Jan Westra; Thomas W Winkler; Tsegaselassie Workalemahu; Jing Hua Zhao; Devin Absher; Eva Albrecht; Denise Anderson; Jeffrey Baron; Marian Beekman; Ayse Demirkan; Georg B Ehret; Bjarke Feenstra; Mary F Feitosa; Krista Fischer; Ross M Fraser; Anuj Goel; Jian Gong; Anne E Justice; Stavroula Kanoni; Marcus E Kleber; Kati Kristiansson; Unhee Lim; Vaneet Lotay; Julian C Lui; Massimo Mangino; Irene Mateo Leach; Carolina Medina-Gomez; Michael A Nalls; Dale R Nyholt; Cameron D Palmer; Dorota Pasko; Sonali Pechlivanis; Inga Prokopenko; Janina S Ried; Stephan Ripke; Dmitry Shungin; Alena Stancáková; Rona J Strawbridge; Yun Ju Sung; Toshiko Tanaka; Alexander Teumer; Stella Trompet; Sander W van der Laan; Jessica van Setten; Jana V Van Vliet-Ostaptchouk; Zhaoming Wang; Loïc Yengo; Weihua Zhang; Uzma Afzal; Johan Arnlöv; Gillian M Arscott; Stefania Bandinelli; Amy Barrett; Claire Bellis; Amanda J Bennett; Christian Berne; Matthias Blüher; Jennifer L Bolton; Yvonne Böttcher; Heather A Boyd; Marcel Bruinenberg; Brendan M Buckley; Steven Buyske; Ida H Caspersen; Peter S Chines; Robert Clarke; Simone Claudi-Boehm; Matthew Cooper; E Warwick Daw; Pim A De Jong; Joris Deelen; Graciela Delgado; Josh C Denny; Rosalie Dhonukshe-Rutten; Maria Dimitriou; Alex S F Doney; Marcus Dörr; Niina Eklund; Elodie Eury; Lasse Folkersen; Melissa E Garcia; Frank Geller; Vilmantas Giedraitis; Alan S Go; Harald Grallert; Tanja B Grammer; Jürgen Gräßler; Henrik Grönberg; Lisette C P G M de Groot; Christopher J Groves; Jeffrey Haessler; Per Hall; Toomas Haller; Goran Hallmans; Anke Hannemann; Catharina A Hartman; Maija Hassinen; Caroline Hayward; Nancy L Heard-Costa; Quinta Helmer; Gibran Hemani; Anjali K Henders; Hans L Hillege; Mark A Hlatky; Wolfgang Hoffmann; Per Hoffmann; Oddgeir Holmen; Jeanine J Houwing-Duistermaat; Thomas Illig; Aaron Isaacs; Alan L James; Janina Jeff; Berit Johansen; Åsa Johansson; Jennifer Jolley; Thorhildur Juliusdottir; Juhani Junttila; Abel N Kho; Leena Kinnunen; Norman Klopp; Thomas Kocher; Wolfgang Kratzer; Peter Lichtner; Lars Lind; Jaana Lindström; Stéphane Lobbens; Mattias Lorentzon; Yingchang Lu; Valeriya Lyssenko; Patrik K E Magnusson; Anubha Mahajan; Marc Maillard; Wendy L McArdle; Colin A McKenzie; Stela McLachlan; Paul J McLaren; Cristina Menni; Sigrun Merger; Lili Milani; Alireza Moayyeri; Keri L Monda; Mario A Morken; Gabriele Müller; Martina Müller-Nurasyid; Arthur W Musk; Narisu Narisu; Matthias Nauck; Ilja M Nolte; Markus M Nöthen; Laticia Oozageer; Stefan Pilz; Nigel W Rayner; Frida Renstrom; Neil R Robertson; Lynda M Rose; Ronan Roussel; Serena Sanna; Hubert Scharnagl; Salome Scholtens; Fredrick R Schumacher; Heribert Schunkert; Robert A Scott; Joban Sehmi; Thomas Seufferlein; Jianxin Shi; Karri Silventoinen; Johannes H Smit; Albert Vernon Smith; Joanna Smolonska; Alice V Stanton; Kathleen Stirrups; David J Stott; Heather M Stringham; Johan Sundström; Morris A Swertz; Ann-Christine Syvänen; Bamidele O Tayo; Gudmar Thorleifsson; Jonathan P Tyrer; Suzanne van Dijk; Natasja M van Schoor; Nathalie van der Velde; Diana van Heemst; Floor V A van Oort; Sita H Vermeulen; Niek Verweij; Judith M Vonk; Lindsay L Waite; Melanie Waldenberger; Roman Wennauer; Lynne R Wilkens; Christina Willenborg; Tom Wilsgaard; Mary K Wojczynski; Andrew Wong; Alan F Wright; Qunyuan Zhang; Dominique Arveiler; Stephan J L Bakker; John Beilby; Richard N Bergman; Sven Bergmann; Reiner Biffar; John Blangero; Dorret I Boomsma; Stefan R Bornstein; Pascal Bovet; Paolo Brambilla; Morris J Brown; Harry Campbell; Mark J Caulfield; Aravinda Chakravarti; Rory Collins; Francis S Collins; Dana C Crawford; L Adrienne Cupples; John Danesh; Ulf de Faire; Hester M den Ruijter; Raimund Erbel; Jeanette Erdmann; Johan G Eriksson; Martin Farrall; Ele Ferrannini; Jean Ferrières; Ian Ford; Nita G Forouhi; Terrence Forrester; Ron T Gansevoort; Pablo V Gejman; Christian Gieger; Alain Golay; Omri Gottesman; Vilmundur Gudnason; Ulf Gyllensten; David W Haas; Alistair S Hall; Tamara B Harris; Andrew T Hattersley; Andrew C Heath; Christian Hengstenberg; Andrew A Hicks; Lucia A Hindorff; Aroon D Hingorani; Albert Hofman; G Kees Hovingh; Steve E Humphries; Steven C Hunt; Elina Hypponen; Kevin B Jacobs; Marjo-Riitta Jarvelin; Pekka Jousilahti; Antti M Jula; Jaakko Kaprio; John J P Kastelein; Manfred Kayser; Frank Kee; Sirkka M Keinanen-Kiukaanniemi; Lambertus A Kiemeney; Jaspal S Kooner; Charles Kooperberg; Seppo Koskinen; Peter Kovacs; Aldi T Kraja; Meena Kumari; Johanna Kuusisto; Timo A Lakka; Claudia Langenberg; Loic Le Marchand; Terho Lehtimäki; Sara Lupoli; Pamela A F Madden; Satu Männistö; Paolo Manunta; André Marette; Tara C Matise; Barbara McKnight; Thomas Meitinger; Frans L Moll; Grant W Montgomery; Andrew D Morris; Andrew P Morris; Jeffrey C Murray; Mari Nelis; Claes Ohlsson; Albertine J Oldehinkel; Ken K Ong; Willem H Ouwehand; Gerard Pasterkamp; Annette Peters; Peter P Pramstaller; Jackie F Price; Lu Qi; Olli T Raitakari; Tuomo Rankinen; D C Rao; Treva K Rice; Marylyn Ritchie; Igor Rudan; Veikko Salomaa; Nilesh J Samani; Jouko Saramies; Mark A Sarzynski; Peter E H Schwarz; Sylvain Sebert; Peter Sever; Alan R Shuldiner; Juha Sinisalo; Valgerdur Steinthorsdottir; Ronald P Stolk; Jean-Claude Tardif; Anke Tönjes; Angelo Tremblay; Elena Tremoli; Jarmo Virtamo; Marie-Claude Vohl; Philippe Amouyel; Folkert W Asselbergs; Themistocles L Assimes; Murielle Bochud; Bernhard O Boehm; Eric Boerwinkle; Erwin P Bottinger; Claude Bouchard; Stéphane Cauchi; John C Chambers; Stephen J Chanock; Richard S Cooper; Paul I W de Bakker; George Dedoussis; Luigi Ferrucci; Paul W Franks; Philippe Froguel; Leif C Groop; Christopher A Haiman; Anders Hamsten; M Geoffrey Hayes; Jennie Hui; David J Hunter; Kristian Hveem; J Wouter Jukema; Robert C Kaplan; Mika Kivimaki; Diana Kuh; Markku Laakso; Yongmei Liu; Nicholas G Martin; Winfried März; Mads Melbye; Susanne Moebus; Patricia B Munroe; Inger Njølstad; Ben A Oostra; Colin N A Palmer; Nancy L Pedersen; Markus Perola; Louis Pérusse; Ulrike Peters; Joseph E Powell; Chris Power; Thomas Quertermous; Rainer Rauramaa; Eva Reinmaa; Paul M Ridker; Fernando Rivadeneira; Jerome I Rotter; Timo E Saaristo; Danish Saleheen; David Schlessinger; P Eline Slagboom; Harold Snieder; Tim D Spector; Konstantin Strauch; Michael Stumvoll; Jaakko Tuomilehto; Matti Uusitupa; Pim van der Harst; Henry Völzke; Mark Walker; Nicholas J Wareham; Hugh Watkins; H-Erich Wichmann; James F Wilson; Pieter Zanen; Panos Deloukas; Iris M Heid; Cecilia M Lindgren; Karen L Mohlke; Elizabeth K Speliotes; Unnur Thorsteinsdottir; Inês Barroso; Caroline S Fox; Kari E North; David P Strachan; Jacques S Beckmann; Sonja I Berndt; Michael Boehnke; Ingrid B Borecki; Mark I McCarthy; Andres Metspalu; Kari Stefansson; André G Uitterlinden; Cornelia M van Duijn; Lude Franke; Cristen J Willer; Alkes L Price; Guillaume Lettre; Ruth J F Loos; Michael N Weedon; Erik Ingelsson; Jeffrey R O'Connell; Goncalo R Abecasis; Daniel I Chasman; Michael E Goddard; Peter M Visscher; Joel N Hirschhorn; Timothy M Frayling
Journal: Nat Genet Date: 2014-10-05 Impact factor: 38.330

10. Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.

Authors: Pooja Jha; Molly T McDevitt; Emina Halilbasic; Evan G Williams; Pedro M Quiros; Karim Gariani; Maroun B Sleiman; Rahul Gupta; Arne Ulbrich; Adam Jochem; Joshua J Coon; Michael Trauner; David J Pagliarini; Johan Auwerx
Journal: Cell Syst Date: 2018-06-13 Impact factor: 10.304

27 in total

1. Multiomic profiling of the liver across diets and age in a diverse mouse population.

Authors: Evan G Williams; Niklas Pfister; Suheeta Roy; Cyril Statzer; Jack Haverty; Jesse Ingels; Casey Bohl; Moaraj Hasan; Jelena Čuklina; Peter Bühlmann; Nicola Zamboni; Lu Lu; Collin Y Ewald; Robert W Williams; Ruedi Aebersold
Journal: Cell Syst Date: 2021-10-18 Impact factor: 10.304

A platform for experimental precision medicine: The extended BXD mouse family.

1. WebQTL: web-based complex trait analysis.

2. Quantitative trait mapping in a diallel cross of recombinant inbred lines.

3. Inbreeding and Linkage.

Review 4. Informatics resources for the Collaborative Cross and related mouse populations.

5. GeneNetwork: A Toolbox for Systems Genetics.

6. Predictive, preventive, personalized and participatory medicine: back to the future.

7. Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains.

8. Linking traits based on their shared molecular mechanisms.

9. Defining the role of common variation in the genomic and biological architecture of adult human height.

10. Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.

1. Multiomic profiling of the liver across diets and age in a diverse mouse population.

Review 2. Brain-iron deficiency models of restless legs syndrome.

Review 3. Meiotic drive in house mice: mechanisms, consequences, and insights for human biology.

Review 4. Translational approaches to understanding resilience to Alzheimer's disease.

5. A systems genetics approach delineates the role of Bcl2 in leukemia pathogenesis.

6. A natural mutator allele shapes mutation spectrum variation in mice.

7. Identification of cyclin D1 as a major modulator of 3-nitropropionic acid-induced striatal neurodegeneration.

8. Evaluating the power and limitations of genome-wide association studies in Caenorhabditis elegans.

9. Genetic loci and metabolic states associated with murine epigenetic aging.

10. Genetic differences in ethanol consumption: effects on iron, copper, and zinc regulation in mouse hippocampus.