Literature DB >> 15043217

WebQTL: web-based complex trait analysis.

Jintao Wang1, Robert W Williams, Kenneth F Manly.   

Abstract

WebQTL is a website that combines databases of complex traits with fast software for mapping quantitative trait loci (QTLs) and for searching for correlations among traits. WebQTL also includes well-curated genotype data for five sets of mouse recombinant inbred (RI) lines. Thus, to identify QTLs, users need provide only quantitative trait data from one of the supported populations. The WebQTL databases include both biological traits--neuroanatomical, pharmacological, and behavioral traits--and microarray-based gene expression data from BXD RI lines. A search function finds correlations between RNA expression and biological traits, and mapping functions find QTLs for either type of trait. The WebQTL service is available at http://www.webqtl.org/.

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Year:  2003        PMID: 15043217     DOI: 10.1385/NI:1:4:299

Source DB:  PubMed          Journal:  Neuroinformatics        ISSN: 1539-2791


  21 in total

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Review 6.  Complex-trait genetics: emergence of multivariate strategies.

Authors:  Tamara J Phillips; John K Belknap
Journal:  Nat Rev Neurosci       Date:  2002-06       Impact factor: 34.870

7.  A simple regression method for mapping quantitative trait loci in line crosses using flanking markers.

Authors:  C S Haley; S A Knott
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8.  Methods for multiple-marker mapping of quantitative trait loci in half-sib populations.

Authors:  S A Knott; J M Elsen; C S Haley
Journal:  Theor Appl Genet       Date:  1996-07       Impact factor: 5.699

9.  Informatics center for mouse genomics: the dissection of complex traits of the nervous system.

Authors:  Glenn D Rosen; Nathan T La Porte; Boris Diechtiareff; Christopher J Pung; Jonathan Nissanov; Carl Gustafson; Louise Bertrand; Smadar Gefen; Yingli Fan; Oleh J Tretiak; Kenneth F Manly; Melburn R Park; Alexander G Williams; Michael T Connolly; John A Capra; Robert W Williams
Journal:  Neuroinformatics       Date:  2003

10.  The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis.

Authors:  R W Williams; J Gu; S Qi; L Lu
Journal:  Genome Biol       Date:  2001-10-22       Impact factor: 13.583

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Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-07-29       Impact factor: 6.237

Review 5.  Expression genetics and the phenotype revolution.

Authors:  Robert W Williams
Journal:  Mamm Genome       Date:  2006-06-12       Impact factor: 2.957

6.  How replicable are mRNA expression QTL?

Authors:  Jeremy L Peirce; Hongqiang Li; Jintao Wang; Kenneth F Manly; Robert J Hitzemann; John K Belknap; Glenn D Rosen; Shirlean Goodwin; Thomas R Sutter; Robert W Williams; Lu Lu
Journal:  Mamm Genome       Date:  2006-06-12       Impact factor: 2.957

7.  Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases.

Authors:  Richard A Radcliffe; Michael J Lee; Robert W Williams
Journal:  Mamm Genome       Date:  2006-06-12       Impact factor: 2.957

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Authors:  Patrizia Porcu; A Leslie Morrow
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9.  A statistical framework for revealing signaling pathways perturbed by DNA variants.

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10.  The genetic contribution to heart rate and heart rate variability in quiescent mice.

Authors:  Reuben Howden; Eric Liu; Laura Miller-DeGraff; Heather L Keener; Christopher Walker; James A Clark; Page H Myers; D Clay Rouse; Tim Wiltshire; Steven R Kleeberger
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-05-02       Impact factor: 4.733

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