Gen Li1,2, Wang Li1, Jingbo Chen2, Shuanglin Zhao2, Zelin Bai2, Qi Liu1, Qi Liao1, Minglian He3,4,5, Wei Zhuang2, Mingsheng Chen2, Jian Sun6,7,8,9, Yujie Chen10,11,12. 1. Department of Biomedical Engineering, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China. 2. Department of Biomedical Engineering, Army Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. 3. Department of Neurosurgery, Southwest Hospital, Army Medical University, 29 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. 4. State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China. 5. Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Army Medical University, Chongqing, China. 6. Department of Biomedical Engineering, Army Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. 30067982@qq.com. 7. Department of Neurosurgery, Southwest Hospital, Army Medical University, 29 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. 30067982@qq.com. 8. State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China. 30067982@qq.com. 9. Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Army Medical University, Chongqing, China. 30067982@qq.com. 10. Department of Neurosurgery, Southwest Hospital, Army Medical University, 29 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. yujiechen6886@foxmail.com. 11. State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China. yujiechen6886@foxmail.com. 12. Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Army Medical University, Chongqing, China. yujiechen6886@foxmail.com.
Abstract
BACKGROUND: To investigate the feasibility of intracranial pressure (ICP) monitoring after traumatic brain injury (TBI) by electromagnetic coupling phase sensing, we established a portable electromagnetic coupling phase shift (ECPS) test system and conducted a comparison with invasive ICP. METHODS: TBI rabbits' model were all synchronously monitored for 24 h by ECPS testing and invasive ICP. We investigated the abilities of the ECPS to detect targeted ICP by feature extraction and traditional classification decision algorithms. RESULTS: The ECPS showed an overall downward trend with a variation range of - 13.370 ± 2.245° as ICP rose from 11.450 ± 0.510 mmHg to 38.750 ± 4.064 mmHg, but its change rate gradually declined. It was greater than 1.5°/h during the first 6 h, then decreased to 0.5°/h and finally reached the minimum of 0.14°/h. Nonlinear regression analysis results illustrated that both the ECPS and its change rate decrease with increasing ICP post-TBI. When used as a recognition feature, the ability (area under the receiver operating characteristic curve, AUCs) of the ECPS to detect ICP ≥ 20 mmHg was 0.88 ± 0.01 based on the optimized adaptive boosting model, reaching the advanced level of current noninvasive ICP assessment methods. CONCLUSIONS: The ECPS has the potential to be used for noninvasive continuous monitoring of elevated ICP post-TBI.
BACKGROUND: To investigate the feasibility of intracranial pressure (ICP) monitoring after traumatic brain injury (TBI) by electromagnetic coupling phase sensing, we established a portable electromagnetic coupling phase shift (ECPS) test system and conducted a comparison with invasive ICP. METHODS: TBI rabbits' model were all synchronously monitored for 24 h by ECPS testing and invasive ICP. We investigated the abilities of the ECPS to detect targeted ICP by feature extraction and traditional classification decision algorithms. RESULTS: The ECPS showed an overall downward trend with a variation range of - 13.370 ± 2.245° as ICP rose from 11.450 ± 0.510 mmHg to 38.750 ± 4.064 mmHg, but its change rate gradually declined. It was greater than 1.5°/h during the first 6 h, then decreased to 0.5°/h and finally reached the minimum of 0.14°/h. Nonlinear regression analysis results illustrated that both the ECPS and its change rate decrease with increasing ICP post-TBI. When used as a recognition feature, the ability (area under the receiver operating characteristic curve, AUCs) of the ECPS to detect ICP ≥ 20 mmHg was 0.88 ± 0.01 based on the optimized adaptive boosting model, reaching the advanced level of current noninvasive ICP assessment methods. CONCLUSIONS: The ECPS has the potential to be used for noninvasive continuous monitoring of elevated ICP post-TBI.
Authors: Christopher P Kellner; Eric Sauvageau; Kenneth V Snyder; Kyle M Fargen; Adam S Arthur; Raymond D Turner; Andrei V Alexandrov Journal: J Neurointerv Surg Date: 2018-03-06 Impact factor: 5.836
Authors: Cesar A Gonzalez; Jose A Valencia; Alfredo Mora; Fernando Gonzalez; Beatriz Velasco; Martin A Porras; Javier Salgado; Salvador M Polo; Nidiyare Hevia-Montiel; Sergio Cordero; Boris Rubinsky Journal: PLoS One Date: 2013-05-14 Impact factor: 3.240