| Literature DB >> 33452978 |
A A Spasov1,2, N A Gurova3, T A Popova1, V N Perfilova1, V V Vishnevskaya1, M V Kustova1, N V Ovsyankina1, A A Ozerov1,2.
Abstract
Uncoupling of respiration and ATP production by myocardial mitochondria was observed in rats with chronic isoproterenol intoxication (L-isoproterenol subcutaneously, 1 mg/kg, for 10 days) in comparison with controls (injected with the solvent). Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally, 13 days) and BMA-1321 compound (0.92 mg/kg intraperitoneally, 13 days) improved the mitochondrial function in rats with isoproterenol-induced cardiac failure: respiratory control coefficients increased, more so for the respiratory chain complex II, the main source of ROS in heart failure. The effect of BMA-1321 was more manifest (53%; p<0.05) in comparison with zoniporide (35%; p<0.05).Entities:
Keywords: (NHE-1) inhibitors; Na-H exchange; experimental chronic heart failure; mitochondrial dysfunction
Year: 2021 PMID： 33452978 DOI： 10.1007/s10517-021-05059-w
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804