Literature DB >> 24228483

[Cardioprotective properties of zoniporide studied on experimental ischemia and reperfusion models in rat myocardium].

N A Gurova, A A Spasov, A S Timofeeva, A A Zheltova, V Iu Fedorchuk.   

Abstract

Using the experimental model of rat heart ischemia/reperfusion, it is established that zoniporide (inhibitor of Na+/H+ exchanger) produces a significant (1.4-fold) decrease in the area of myocardial necrosis, 2.1-fold decrease in the serum troponin I level, and 2-fold decrease in the severity of post-reperfusion arrhythmias.

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Year:  2013        PMID： 24228483

Source DB:  PubMed          Journal:  Eksp Klin Farmakol        ISSN： 0869-2092


  2 in total

1.  Effects of Zoniporide and BMA-1321 Compound on the Rate of Oxygen Absorption by Cardiomyocyte Mitochondria in Rats with Experimental Chronic Heart Failure.

Authors:  A A Spasov; N A Gurova; T A Popova; V N Perfilova; V V Vishnevskaya; M V Kustova; N V Ovsyankina; A A Ozerov
Journal:  Bull Exp Biol Med       Date:  2021-01-16       Impact factor: 0.804

2.  Synthesis and multifaceted pharmacological activity of novel quinazoline NHE-1 inhibitors.

Authors:  Alexander Spasov; Alexander Ozerov; Pavel Vassiliev; Vadim Kosolapov; Denis Babkov; Natalia Gurova; Aida Kucheryavenko; Ludmila Naumenko; Viktor Sirotenko; Alena Taran; Roman Litvinov; Alexander Borisov; Vladlen Klochkov; Darya Merezhkina; Mikhail Miroshnikov; Georgy Uskov; Nadezhda Ovsyankina
Journal:  Sci Rep       Date:  2021-12-21       Impact factor: 4.379
  2 in total

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