| Literature DB >> 29949696 |
A A Spasov, V U Murav'eva, N A Gurova, N I Cheplyaeva, E V Reznikov, V A Anisimova.
Abstract
Primary neuroprotective properties of new inhibitor of Na⁺/⁺ exchanger (compound RU-1355) were established on the model of 60-min focal ischemia of the left middle cerebral artery followed by 24-h reperfusion in rats. Compound RU-1355 significantly (by 34%) decreased neurological symptoms, reduced (1.67 times) the growth of neuron-specific enolase level in serum, decreased (2.3 times) the size of the necrotic zone, and reduced by 59% (p <0.05) the degree of cerebral edema According to the results of morphometric, immunoassay, and neurological assessments of brain damage, compound RU-1355 is superior on ave- rage by 43.5% (p < 0.05) in comparison to selective NHE1 inhibitor zoniporide.Entities:
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Year: 2016 PMID： 29949696
Source DB: PubMed Journal: Eksp Klin Farmakol ISSN： 0869-2092