Alessandra Colombini1, Fabio Galbusera2, Maria Cristina Cortese3, Enrico Gallazzi4, Marco Viganò5, Domenico Albano6,7, Sabina Cauci8, Luca Maria Sconfienza6,9, Marco Brayda-Bruno10. 1. Orthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. alessandra.colombini@grupposandonato.it. 2. LABS-Laboratory of Biological Structures Mechanics, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. 3. Dipartimento Di Scienze Radiologiche, Distretto Ospedaliero Dell'A.S.P. Catania Ospedale "Gravina E Santo Pietro", Caltagirone, Italy. 4. Ortopedia E Traumatologia III, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milan, Italy. 5. Orthopaedic Biotechnology Lab, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. 6. Unità Operativa Di Radiologia Diagnostica Ed Interventistica, IRCCS Istituto Ortopedico Galeazzi, 20161, Milan, Italy. 7. Sezione Di Scienze Radiologiche, Dipartimento Di Biomedicina, Neuroscienze E Diagnostica Avanzata, Università Degli Studi Di Palermo, 90127, Palermo, Italy. 8. Department of Medicine, University of Udine, 33100, Udine, Italy. 9. Department of Biomedical Science for Health, University of Milan, 20133, Milan, Italy. 10. III Spine Surgery - Scoliosis Department, IRCCS Istituto Ortopedico Galeazzi, 20161, Milan, Italy.
Abstract
PURPOSE: To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls. METHODS: In this observational retrospective study, T2-weighted sagittal MRI images (n = 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2-L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels, n = 69 males) and VDR variables. RESULTS: Males showed higher BMI and total MRI score than females. Patients bearing TT compared to tt VDR genotypes showed significant higher total MRI scores. Among males (n = 125), TT, bb and aa genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (n = 69 males). CONCLUSIONS: The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.
PURPOSE: To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathypatients and healthy controls. METHODS: In this observational retrospective study, T2-weighted sagittal MRI images (n = 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2-L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels, n = 69 males) and VDR variables. RESULTS: Males showed higher BMI and total MRI score than females. Patients bearing TT compared to tt VDR genotypes showed significant higher total MRI scores. Among males (n = 125), TT, bb and aa genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (n = 69 males). CONCLUSIONS: The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.
Authors: Marco Brayda-Bruno; Marco Viganò; Sabina Cauci; Jacopo A Vitale; Laura de Girolamo; Paola De Luca; Giovanni Lombardi; Giuseppe Banfi; Alessandra Colombini Journal: Clin Chim Acta Date: 2017-05-22 Impact factor: 3.786