Literature DB >> 33446486

On the utility of CSF1R inhibitors.

Kim N Green1, David A Hume2.   

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Year:  2021        PMID: 33446486      PMCID: PMC7848745          DOI: 10.1073/pnas.2019695118

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   12.779


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  8 in total

1.  An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation.

Authors:  Kelli P A MacDonald; James S Palmer; Stephen Cronau; Elke Seppanen; Stuart Olver; Neil C Raffelt; Rachel Kuns; Allison R Pettit; Andrew Clouston; Brandon Wainwright; Dan Branstetter; Jeffrey Smith; Raymond J Paxton; Douglas Pat Cerretti; Lynn Bonham; Geoffrey R Hill; David A Hume
Journal:  Blood       Date:  2010-08-03       Impact factor: 22.113

2.  A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System.

Authors:  Kathleen Grabert; Anuj Sehgal; Katharine M Irvine; Evi Wollscheid-Lengeling; Derya D Ozdemir; Jennifer Stables; Garry A Luke; Martin D Ryan; Antony Adamson; Neil E Humphreys; Cheyenne J Sandrock; Rocio Rojo; Veera A Verkasalo; Werner Mueller; Peter Hohenstein; Allison R Pettit; Clare Pridans; David A Hume
Journal:  J Immunol       Date:  2020-11-02       Impact factor: 5.422

Review 3.  Phenotypic impacts of CSF1R deficiencies in humans and model organisms.

Authors:  David A Hume; Melanie Caruso; Michelle Ferrari-Cestari; Kim M Summers; Clare Pridans; Katharine M Irvine
Journal:  J Leukoc Biol       Date:  2019-07-22       Impact factor: 4.962

4.  Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

Authors:  Martin Valdearcos; Megan M Robblee; Daniel I Benjamin; Daniel K Nomura; Allison W Xu; Suneil K Koliwad
Journal:  Cell Rep       Date:  2014-12-11       Impact factor: 9.423

Review 5.  To Kill a Microglia: A Case for CSF1R Inhibitors.

Authors:  Kim N Green; Joshua D Crapser; Lindsay A Hohsfield
Journal:  Trends Immunol       Date:  2020-08-10       Impact factor: 16.687

6.  Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.

Authors:  Rocío Rojo; Anna Raper; Derya D Ozdemir; Lucas Lefevre; Kathleen Grabert; Evi Wollscheid-Lengeling; Barry Bradford; Melanie Caruso; Iveta Gazova; Alejandra Sánchez; Zofia M Lisowski; Joana Alves; Irene Molina-Gonzalez; Hayk Davtyan; Rebecca J Lodge; James D Glover; Robert Wallace; David A D Munro; Eyal David; Ido Amit; Véronique E Miron; Josef Priller; Stephen J Jenkins; Giles E Hardingham; Mathew Blurton-Jones; Neil A Mabbott; Kim M Summers; Peter Hohenstein; David A Hume; Clare Pridans
Journal:  Nat Commun       Date:  2019-07-19       Impact factor: 14.919

7.  Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.

Authors:  Elizabeth Spangenberg; Paul L Severson; Lindsay A Hohsfield; Joshua Crapser; Jiazhong Zhang; Elizabeth A Burton; Ying Zhang; Wayne Spevak; Jack Lin; Nicole Y Phan; Gaston Habets; Andrey Rymar; Garson Tsang; Jason Walters; Marika Nespi; Parmveer Singh; Stephanie Broome; Prabha Ibrahim; Chao Zhang; Gideon Bollag; Brian L West; Kim N Green
Journal:  Nat Commun       Date:  2019-08-21       Impact factor: 14.919

8.  CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages.

Authors:  Fengyang Lei; Naiwen Cui; Chengxin Zhou; James Chodosh; Demetrios G Vavvas; Eleftherios I Paschalis
Journal:  Proc Natl Acad Sci U S A       Date:  2020-09-08       Impact factor: 11.205

  8 in total
  8 in total

Review 1.  Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function.

Authors:  Alanna G Spiteri; Claire L Wishart; Roger Pamphlett; Giuseppe Locatelli; Nicholas J C King
Journal:  Acta Neuropathol       Date:  2021-12-01       Impact factor: 17.088

Review 2.  Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain.

Authors:  Sebastian Parusel; Min-Hee Yi; Christine L Hunt; Long-Jun Wu
Journal:  Neurosci Bull       Date:  2022-08-17       Impact factor: 5.271

3.  Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622.

Authors:  Fengyang Lei; Naiwen Cui; Chengxin Zhou; James Chodosh; Demetrios G Vavvas; Eleftherios I Paschalis
Journal:  Proc Natl Acad Sci U S A       Date:  2021-01-26       Impact factor: 12.779

4.  Microglia Reduce Herpes Simplex Virus 1 Lethality of Mice with Decreased T Cell and Interferon Responses in Brains.

Authors:  Meng-Shan Tsai; Li-Chiu Wang; Hsien-Yang Tsai; Yu-Jheng Lin; Hua-Lin Wu; Shun-Fen Tzeng; Sheng-Min Hsu; Shun-Hua Chen
Journal:  Int J Mol Sci       Date:  2021-11-18       Impact factor: 5.923

5.  PLX5622 Reduces Disease Severity in Lethal CNS Infection by Off-Target Inhibition of Peripheral Inflammatory Monocyte Production.

Authors:  Alanna G Spiteri; Duan Ni; Zheng Lung Ling; Laurence Macia; Iain L Campbell; Markus J Hofer; Nicholas J C King
Journal:  Front Immunol       Date:  2022-03-25       Impact factor: 7.561

6.  Microglia maintain the normal structure and function of the hippocampal astrocyte network.

Authors:  Yixing Du; Faith H Brennan; Phillip G Popovich; Min Zhou
Journal:  Glia       Date:  2022-04-08       Impact factor: 8.073

7.  Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome.

Authors:  Kevin Aguilar; Gemma Comes; Carla Canal; Albert Quintana; Elisenda Sanz; Juan Hidalgo
Journal:  Glia       Date:  2022-06-30       Impact factor: 8.073

Review 8.  Glial Cells Promote Myelin Formation and Elimination.

Authors:  Alexandria N Hughes
Journal:  Front Cell Dev Biol       Date:  2021-05-11
  8 in total

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