Yahya B Atalay1, Pirouz Piran1, Abhinaba Chatterjee1, Santosh Murthy1, Babak B Navi1, Ava L Liberman1, Joseph Dardick1, Cenai Zhang1, Hooman Kamel1, Alexander E Merkler2. 1. From the Clinical and Translational Neuroscience Unit (Y.B.A., P.P., A.C., S.M., B.B.N., C.Z., H.K., A.E.M.), Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medical College; and Department of Neurology (A.L.L., J.D.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY. 2. From the Clinical and Translational Neuroscience Unit (Y.B.A., P.P., A.C., S.M., B.B.N., C.Z., H.K., A.E.M.), Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medical College; and Department of Neurology (A.L.L., J.D.), Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY. alm9097@med.cornell.edu.
Abstract
OBJECTIVE: To test the hypothesis that the prevalence of cervical artery dissection remains constant across age groups, we evaluated the relationship between age and cervical artery dissection in patients with stroke using a nationally representative sample from the United States. METHODS: We used inpatient claims data included in the 2012-2015 releases of the National Inpatient Sample (NIS). We used validated ICD-9-CM codes to identify adults hospitalized with ischemic stroke and a concomitant diagnosis of carotid or vertebral artery dissection. Survey weights provided by the NIS and population estimates from the US census were used to calculate nationally representative estimates. The χ2 test for trend was used to compare the prevalence of concomitant dissection among stroke hospitalizations across patient subgroups defined by age. Poisson regression and the Wald test for trend were used to evaluate whether the prevalence of hospitalizations for stroke and concomitant dissection per million person-years varied by age groups. RESULTS: There were 17,320 (95% confidence interval [CI], 15,614-19,026) hospitalizations involving ischemic stroke and a concomitant dissection. The prevalence of dissection among stroke hospitalizations decreased across 10-year age groups from 7.2% (95% CI, 6.2%-8.1%) among persons younger than 30 years to 0.2% (95% CI, 0.1%-0.2%) among persons older than 80 years (p value for trend <0.001). However, the prevalence of hospitalizations for stroke and concomitant dissection increased from 5.4 (95% CI, 4.6-6.2) hospitalizations per million person-years among adults younger than 30 to 24.4 (95% CI, 21.0-27.9) hospitalizations per million person-years among adults older than age 80 (p value for trend <0.01). CONCLUSION: In a nationally representative sample, the prevalence of hospitalizations for dissection-related stroke increased with age.
OBJECTIVE: To test the hypothesis that the prevalence of cervical artery dissection remains constant across age groups, we evaluated the relationship between age and cervical artery dissection in patients with stroke using a nationally representative sample from the United States. METHODS: We used inpatient claims data included in the 2012-2015 releases of the National Inpatient Sample (NIS). We used validated ICD-9-CM codes to identify adults hospitalized with ischemic stroke and a concomitant diagnosis of carotid or vertebral artery dissection. Survey weights provided by the NIS and population estimates from the US census were used to calculate nationally representative estimates. The χ2 test for trend was used to compare the prevalence of concomitant dissection among stroke hospitalizations across patient subgroups defined by age. Poisson regression and the Wald test for trend were used to evaluate whether the prevalence of hospitalizations for stroke and concomitant dissection per million person-years varied by age groups. RESULTS: There were 17,320 (95% confidence interval [CI], 15,614-19,026) hospitalizations involving ischemic stroke and a concomitant dissection. The prevalence of dissection among stroke hospitalizations decreased across 10-year age groups from 7.2% (95% CI, 6.2%-8.1%) among persons younger than 30 years to 0.2% (95% CI, 0.1%-0.2%) among persons older than 80 years (p value for trend <0.001). However, the prevalence of hospitalizations for stroke and concomitant dissection increased from 5.4 (95% CI, 4.6-6.2) hospitalizations per million person-years among adults younger than 30 to 24.4 (95% CI, 21.0-27.9) hospitalizations per million person-years among adults older than age 80 (p value for trend <0.01). CONCLUSION: In a nationally representative sample, the prevalence of hospitalizations for dissection-related stroke increased with age.
Authors: Barbara Goeggel Simonetti; Marie-Luise Mono; Uyen Huynh-Do; Patrik Michel; Celine Odier; Roman Sztajzel; Philippe Lyrer; Stefan T Engelter; Leo Bonati; Henrik Gensicke; Christopher Traenka; Barbara Tettenborn; Bruno Weder; Urs Fischer; Aekaterini Galimanis; Simon Jung; Rudolf Luedi; Gian Marco De Marchis; Anja Weck; Carlo W Cereda; Ralf Baumgartner; Claudio L Bassetti; Heinrich P Mattle; Krassen Nedeltchev; Marcel Arnold Journal: J Neurol Date: 2015-06-12 Impact factor: 4.849
Authors: Setareh Salehi Omran; Neal S Parikh; Sharon Poisson; Jennifer Armstrong; Alexander E Merkler; Malavika Prabhu; Babak B Navi; Laura E Riley; Matthew E Fink; Hooman Kamel Journal: Ann Neurol Date: 2020-07-13 Impact factor: 10.422
Authors: N Yesilot Barlas; J Putaala; U Waje-Andreassen; S Vassilopoulou; K Nardi; C Odier; G Hofgart; S Engelter; A Burow; L Mihalka; M Kloss; J Ferrari; R Lemmens; O Coban; E Haapaniemi; N Maaijwee; L Rutten-Jacobs; A Bersano; C Cereda; P Baron; L Borellini; C Valcarenghi; L Thomassen; A J Grau; F Palm; C Urbanek; R Tuncay; A Durukan Tolvanen; E J van Dijk; F E de Leeuw; V Thijs; S Greisenegger; K Vemmos; C Lichy; D Bereczki; L Csiba; P Michel; D Leys; K Spengos; H Naess; T Tatlisumak; S Z Bahar Journal: Eur J Neurol Date: 2013-07-10 Impact factor: 6.089
Authors: A J Metso; T M Metso; S Debette; J Dallongeville; P A Lyrer; A Pezzini; C Lichy; M Kloss; T Brandt; E Touzé; A M Southerland; B B Worrall; S Abboud; E del Zotto; D Leys; S Engelter; C Grond-Ginsbach; T Tatlisumak Journal: Eur J Neurol Date: 2011-12-10 Impact factor: 6.089
Authors: S Debette; C Grond-Ginsbach; M Bodenant; M Kloss; S Engelter; T Metso; A Pezzini; T Brandt; V Caso; E Touzé; A Metso; S Canaple; S Abboud; G Giacalone; P Lyrer; E Del Zotto; M Giroud; Y Samson; J Dallongeville; T Tatlisumak; D Leys; J J Martin Journal: Neurology Date: 2011-09-07 Impact factor: 9.910
Authors: Tiina M Metso; Stéphanie Debette; Caspar Grond-Ginsbach; Stefan T Engelter; Didier Leys; Tobias Brandt; Alessandro Pezzini; Anna Bersano; Manja Kloss; Vincent Thijs; Philippe A Lyrer; Turgut Tatlisumak; Antti J Metso Journal: J Neurol Date: 2012-04-18 Impact factor: 4.849
Authors: Stefan T Engelter; Caspar Grond-Ginsbach; Tiina M Metso; Antti J Metso; Manja Kloss; Stephanie Debette; Didier Leys; Armin Grau; Jean Dallongeville; Marie Bodenant; Yves Samson; Valeria Caso; Alessandro Pezzini; Leo H Bonati; Vincent Thijs; Henrik Gensicke; Juan J Martin; Anna Bersano; Emmanuel Touzé; Turgut Tatlisumak; Philippe A Lyrer; Tobias Brandt Journal: Neurology Date: 2013-05-01 Impact factor: 9.910