BACKGROUND AND PURPOSE: Spontaneous vertebral artery dissection (sVADs) mainly cause cerebral ischemia, with or without associated local symptoms and signs (headache, neck pain, or cervical radiculopathy), or with local symptoms and signs only. METHODS: We compared the presenting characteristics of consecutive patients with single sVADs and ischemic events and those with local symptoms and signs only. RESULTS: Of the 186 patients with first-ever unilateral sVAD, 165 (89%) presented with cerebral ischemia, and 21 (11%) presented with local symptoms and signs only. Patients with sVAD and ischemia were more often male (63% vs 29%; P=0.002), older (mean+/-SD age, 43.6+/-9.9 vs 38.6+/-9.0 years; P=0.027), and smokers (14% vs 3%; P=0.010), but less often, they had a history of migraine without aura (17% vs 38%; P=0.025) than did patients without ischemia. The multivariate analysis confirmed independent associations between male sex (P=0.024), increasing age (0.027), and smoking (P=0.012) and sVADs causing cerebral ischemia. CONCLUSIONS: These results suggest that men, older patients, and smokers with sVADs may be at increased risk for ischemic events.
BACKGROUND AND PURPOSE: Spontaneous vertebral artery dissection (sVADs) mainly cause cerebral ischemia, with or without associated local symptoms and signs (headache, neck pain, or cervical radiculopathy), or with local symptoms and signs only. METHODS: We compared the presenting characteristics of consecutive patients with single sVADs and ischemic events and those with local symptoms and signs only. RESULTS: Of the 186 patients with first-ever unilateral sVAD, 165 (89%) presented with cerebral ischemia, and 21 (11%) presented with local symptoms and signs only. Patients with sVAD and ischemia were more often male (63% vs 29%; P=0.002), older (mean+/-SD age, 43.6+/-9.9 vs 38.6+/-9.0 years; P=0.027), and smokers (14% vs 3%; P=0.010), but less often, they had a history of migraine without aura (17% vs 38%; P=0.025) than did patients without ischemia. The multivariate analysis confirmed independent associations between male sex (P=0.024), increasing age (0.027), and smoking (P=0.012) and sVADs causing cerebral ischemia. CONCLUSIONS: These results suggest that men, older patients, and smokers with sVADs may be at increased risk for ischemic events.
Authors: M S Ali; P S Amenta; R M Starke; P M Jabbour; L F Gonzalez; S I Tjoumakaris; A E Flanders; R H Rosenwasser; A S Dumont Journal: Interv Neuroradiol Date: 2012-12-03 Impact factor: 1.610
Authors: Maximilian Habs; Thomas Pfefferkorn; Clemens C Cyran; Jochen Grimm; Axel Rominger; Marcus Hacker; Christian Opherk; Maximilian F Reiser; Konstantin Nikolaou; Tobias Saam Journal: J Cardiovasc Magn Reson Date: 2011-11-28 Impact factor: 5.364
Authors: Yahya B Atalay; Pirouz Piran; Abhinaba Chatterjee; Santosh Murthy; Babak B Navi; Ava L Liberman; Joseph Dardick; Cenai Zhang; Hooman Kamel; Alexander E Merkler Journal: Neurology Date: 2021-01-04 Impact factor: 9.910