Yimin Cheng1,2, Liting Yang1, Guangyao Shi1, Peng Chen1, Liang Li3, Hangrong Fang4, Chao Chen5. 1. The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China. 2. The Hospital of Xi'an Shiyou University, Xi'an, People's Republic of China. 3. Department of Radiotherapy, Shaanxi Provincial Tumor Hospital, Xi'an, People's Republic of China. 4. Department of Pathology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, People's Republic of China. 5. The National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China. cchen898@nwu.edu.cn.
Abstract
BACKGROUND: Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk. METHODS: Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis. RESULTS: The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR 1.46, 95% CI 1.04-2.06, p = 0.028; OR 8.43, 95% CI 1.05-67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls. CONCLUSION: The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.
BACKGROUND:Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk. METHODS: Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancerpatients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis. RESULTS: The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR 1.46, 95% CI 1.04-2.06, p = 0.028; OR 8.43, 95% CI 1.05-67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls. CONCLUSION: The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancerpatients.
Entities:
Keywords:
Clinical index; Endometrial cancer; Ninjurin2; Single nucleotide polymorphisms
Authors: Jodie N Painter; Susanne Kaufmann; Tracy A O'Mara; Kristine M Hillman; Haran Sivakumaran; Hatef Darabi; Timothy H T Cheng; John Pearson; Stephen Kazakoff; Nicola Waddell; Erling A Hoivik; Ellen L Goode; Rodney J Scott; Ian Tomlinson; Alison M Dunning; Douglas F Easton; Juliet D French; Helga B Salvesen; Pamela M Pollock; Deborah J Thompson; Amanda B Spurdle; Stacey L Edwards Journal: Am J Hum Genet Date: 2016-06-02 Impact factor: 11.025
Authors: Amanda B Spurdle; Deborah J Thompson; Shahana Ahmed; Kaltin Ferguson; Catherine S Healey; Tracy O'Mara; Logan C Walker; Stephen B Montgomery; Emmanouil T Dermitzakis; Paul Fahey; Grant W Montgomery; Penelope M Webb; Peter A Fasching; Matthias W Beckmann; Arif B Ekici; Alexander Hein; Diether Lambrechts; Lieve Coenegrachts; Ignace Vergote; Frederic Amant; Helga B Salvesen; Jone Trovik; Tormund S Njolstad; Harald Helland; Rodney J Scott; Katie Ashton; Tony Proietto; Geoffrey Otton; Ian Tomlinson; Maggie Gorman; Kimberley Howarth; Shirley Hodgson; Montserrat Garcia-Closas; Nicolas Wentzensen; Hannah Yang; Stephen Chanock; Per Hall; Kamila Czene; Jianjun Liu; Jingmei Li; Xiao-Ou Shu; Wei Zheng; Jirong Long; Yong-Bing Xiang; Mitul Shah; Jonathan Morrison; Kyriaki Michailidou; Paul D Pharoah; Alison M Dunning; Douglas F Easton Journal: Nat Genet Date: 2011-04-17 Impact factor: 38.330
Authors: Immaculata De Vivo; Jennifer Prescott; Veronica Wendy Setiawan; Sara H Olson; Nicolas Wentzensen; John Attia; Amanda Black; Louise Brinton; Chu Chen; Constance Chen; Linda S Cook; Marta Crous-Bou; Jennifer Doherty; Alison M Dunning; Douglas F Easton; Christine M Friedenreich; Montserrat Garcia-Closas; Mia M Gaudet; Christopher Haiman; Susan E Hankinson; Patricia Hartge; Brian E Henderson; Elizabeth Holliday; Pamela L Horn-Ross; David J Hunter; Loic Le Marchand; Xiaolin Liang; Jolanta Lissowska; Jirong Long; Lingeng Lu; Anthony M Magliocco; Mark McEvoy; Tracy A O'Mara; Irene Orlow; Jodie N Painter; Loreall Pooler; Radhai Rastogi; Timothy R Rebbeck; Harvey Risch; Carlotta Sacerdote; Fredrick Schumacher; Rodney J Scott; Xin Sheng; Xiao-ou Shu; Amanda B Spurdle; Deborah Thompson; David Vanden Berg; Noel S Weiss; Lucy Xia; Yong-Bing Xiang; Hannah P Yang; Herbert Yu; Wei Zheng; Stephen Chanock; Peter Kraft Journal: Hum Genet Date: 2013-10-06 Impact factor: 4.132
Authors: Timothy Ht Cheng; Deborah J Thompson; Tracy A O'Mara; Jodie N Painter; Dylan M Glubb; Susanne Flach; Annabelle Lewis; Juliet D French; Luke Freeman-Mills; David Church; Maggie Gorman; Lynn Martin; Shirley Hodgson; Penelope M Webb; John Attia; Elizabeth G Holliday; Mark McEvoy; Rodney J Scott; Anjali K Henders; Nicholas G Martin; Grant W Montgomery; Dale R Nyholt; Shahana Ahmed; Catherine S Healey; Mitul Shah; Joe Dennis; Peter A Fasching; Matthias W Beckmann; Alexander Hein; Arif B Ekici; Per Hall; Kamila Czene; Hatef Darabi; Jingmei Li; Thilo Dörk; Matthias Dürst; Peter Hillemanns; Ingo Runnebaum; Frederic Amant; Stefanie Schrauwen; Hui Zhao; Diether Lambrechts; Jeroen Depreeuw; Sean C Dowdy; Ellen L Goode; Brooke L Fridley; Stacey J Winham; Tormund S Njølstad; Helga B Salvesen; Jone Trovik; Henrica Mj Werner; Katie Ashton; Geoffrey Otton; Tony Proietto; Tao Liu; Miriam Mints; Emma Tham; Chibcha Consortium; Mulin Jun Li; Shun H Yip; Junwen Wang; Manjeet K Bolla; Kyriaki Michailidou; Qin Wang; Jonathan P Tyrer; Malcolm Dunlop; Richard Houlston; Claire Palles; John L Hopper; Julian Peto; Anthony J Swerdlow; Barbara Burwinkel; Hermann Brenner; Alfons Meindl; Hiltrud Brauch; Annika Lindblom; Jenny Chang-Claude; Fergus J Couch; Graham G Giles; Vessela N Kristensen; Angela Cox; Julie M Cunningham; Paul D P Pharoah; Alison M Dunning; Stacey L Edwards; Douglas F Easton; Ian Tomlinson; Amanda B Spurdle Journal: Nat Genet Date: 2016-05-02 Impact factor: 38.330