| Literature DB >> 21499250 |
Amanda B Spurdle1, Deborah J Thompson, Shahana Ahmed, Kaltin Ferguson, Catherine S Healey, Tracy O'Mara, Logan C Walker, Stephen B Montgomery, Emmanouil T Dermitzakis, Paul Fahey, Grant W Montgomery, Penelope M Webb, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein, Diether Lambrechts, Lieve Coenegrachts, Ignace Vergote, Frederic Amant, Helga B Salvesen, Jone Trovik, Tormund S Njolstad, Harald Helland, Rodney J Scott, Katie Ashton, Tony Proietto, Geoffrey Otton, Ian Tomlinson, Maggie Gorman, Kimberley Howarth, Shirley Hodgson, Montserrat Garcia-Closas, Nicolas Wentzensen, Hannah Yang, Stephen Chanock, Per Hall, Kamila Czene, Jianjun Liu, Jingmei Li, Xiao-Ou Shu, Wei Zheng, Jirong Long, Yong-Bing Xiang, Mitul Shah, Jonathan Morrison, Kyriaki Michailidou, Paul D Pharoah, Alison M Dunning, Douglas F Easton.
Abstract
Endometrial cancer is the most common malignancy of the female genital tract in developed countries. To identify genetic variants associated with endometrial cancer risk, we performed a genome-wide association study involving 1,265 individuals with endometrial cancer (cases) from Australia and the UK and 5,190 controls from the Wellcome Trust Case Control Consortium. We compared genotype frequencies in cases and controls for 519,655 SNPs. Forty seven SNPs that showed evidence of association with endometrial cancer in stage 1 were genotyped in 3,957 additional cases and 6,886 controls. We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.Entities:
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Year: 2011 PMID： 21499250 PMCID： PMC3770523 DOI： 10.1038/ng.812
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330