Jan Bieńkiewicz1, Hanna Romanowicz2, Andrzej Malinowski3, Beata Smolarz4. 1. Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mothers' Memorial Hospital-Research Institute, Lodz, Poland. Electronic address: jan.a.bienkiewicz@gmail.com. 2. Department of Clinical Pathology, Polish Mothers' Memorial Hospital-Research Institute, Lodz, Poland. 3. Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mothers' Memorial Hospital-Research Institute, Lodz, Poland. 4. Laboratory of Cancer Genetics, Department of Clinical Pathology, Polish Mothers' Memorial Hospital-Research Institute, Lodz, Poland.
Abstract
AIM: The aim of this study was to analyse the frequencies of genotypes and alleles of Single Nucleotide Polymorphism (SNP) -2548 G/A (rs12112075) of leptin gene (LEP) and an attempt to evaluate the effect this DNA marker has on endometrial cancer (EC) and uterine leiomyomas (UL). MATERIAL AND METHODS: The study comprised 120 patients treated for endometrial cancer and 90 patients treated for uterine leiomyomas. 90 disease-free individuals were used as controls. In total, 300 patients were investigated in this research. RESULTS: In this paper we have demonstrated that genotype AG of SNP -2548 G/A of LEP may reduce the risk of developing endometrial cancer, whereas allele A itself may be a risk factor of this malignancy. No association was found between the studied polymorphism and uterine leiomyomas. CONCLUSIONS: -2548 G/A SNP of LEP may play a significant role in the development of EC, however, uterine leiomyomas are not associated with this DNA marker.
AIM: The aim of this study was to analyse the frequencies of genotypes and alleles of Single Nucleotide Polymorphism (SNP) -2548 G/A (rs12112075) of leptin gene (LEP) and an attempt to evaluate the effect this DNA marker has on endometrial cancer (EC) and uterine leiomyomas (UL). MATERIAL AND METHODS: The study comprised 120 patients treated for endometrial cancer and 90 patients treated for uterine leiomyomas. 90 disease-free individuals were used as controls. In total, 300 patients were investigated in this research. RESULTS: In this paper we have demonstrated that genotype AG of SNP -2548 G/A of LEP may reduce the risk of developing endometrial cancer, whereas allele A itself may be a risk factor of this malignancy. No association was found between the studied polymorphism and uterine leiomyomas. CONCLUSIONS: -2548 G/A SNP of LEP may play a significant role in the development of EC, however, uterine leiomyomas are not associated with this DNA marker.
Authors: Jan Bieńkiewicz; Hanna Romanowicz; Miłosz Wilczyński; Grzegorz Jabłoński; Anna Stepowicz; Anna Obłękowska; Andrzej Malinowski; Beata Smolarz Journal: BMC Cancer Date: 2021-08-16 Impact factor: 4.430