Literature DB >> 33384981

Current and Promising Antivirals Against Chikungunya Virus.

Friederike I L Hucke1, Joachim J Bugert1.   

Abstract

Chikungunya virus (CHIKV) is the causative agent of chikungunya fever (CHIKF) and is categorized as a(n) (re)emerging arbovirus. CHIKV has repeatedly been responsible for outbreaks that caused serious economic and public health problems in the affected countries. To date, no vaccine or specific antiviral therapies are available. This review gives a summary on current antivirals that have been investigated as potential therapeutics against CHIKF. The mode of action as well as possible compound targets (viral and host targets) are being addressed. This review hopes to provide critical information on the in vitro efficacies of various compounds and might help researchers in their considerations for future experiments.
Copyright © 2020 Hucke and Bugert.

Entities:  

Keywords:  CHIKV therapy; antiviral design; comparison of in vitro efficacies; direct antiviral action; favipiravir; host-targeting antiviral; ribavirin

Mesh：

Substances：

Year:  2020        PMID： 33384981      PMCID： PMC7769948          DOI： 10.3389/fpubh.2020.618624

Source DB:  PubMed          Journal:  Front Public Health        ISSN： 2296-2565


  205 in total

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Review 2.  Enzymology of RNA cap synthesis.

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Authors:  Robert Lyle McPherson; Rachy Abraham; Easwaran Sreekumar; Shao-En Ong; Shang-Jung Cheng; Victoria K Baxter; Hans A V Kistemaker; Dmitri V Filippov; Diane E Griffin; Anthony K L Leung
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-31       Impact factor: 11.205

4.  RNA interference mediated inhibition of Chikungunya virus replication in mammalian cells.

Authors:  Paban Kumar Dash; Mugdha Tiwari; S R Santhosh; Manmohan Parida; P V Lakshmana Rao
Journal:  Biochem Biophys Res Commun       Date:  2008-09-19       Impact factor: 3.575

Review 5.  Protein kinase C as a tumor suppressor.

Authors:  Alexandra C Newton
Journal:  Semin Cancer Biol       Date:  2017-05-02       Impact factor: 15.707

6.  The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase.

Authors:  Pieter Leyssen; Jan Balzarini; Erik De Clercq; Johan Neyts
Journal:  J Virol       Date:  2005-02       Impact factor: 5.103

7.  Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks.

Authors:  Florent Olivon; Pierre-Marie Allard; Alexey Koval; Davide Righi; Gregory Genta-Jouve; Johan Neyts; Cécile Apel; Christophe Pannecouque; Louis-Félix Nothias; Xavier Cachet; Laurence Marcourt; Fanny Roussi; Vladimir L Katanaev; David Touboul; Jean-Luc Wolfender; Marc Litaudon
Journal:  ACS Chem Biol       Date:  2017-09-15       Impact factor: 5.100

Review 8.  Preferential suppression of lymphocyte proliferation by mycophenolic acid and predicted long-term effects of mycophenolate mofetil in transplantation.

Authors:  A C Allison; E M Eugui
Journal:  Transplant Proc       Date:  1994-12       Impact factor: 1.066

Review 9.  Molecular determinants of alphavirus neuropathogenesis in mice.

Authors:  Gregory J Atkins; Brian J Sheahan
Journal:  J Gen Virol       Date:  2016-03-30       Impact factor: 3.891

10.  Sofosbuvir: A novel treatment option for chronic hepatitis C infection.

Authors:  Harmeet Kaur Bhatia; Harmanjit Singh; Nipunjot Grewal; Navreet Kaur Natt
Journal:  J Pharmacol Pharmacother       Date:  2014-10
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1.  MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo.

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Journal:  Antimicrob Agents Chemother       Date:  2022-06-29       Impact factor: 5.938

Review 2.  A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development.

Authors:  Thaise Yasmine Vasconcelos de Lima Cavalcanti; Mylena Ribeiro Pereira; Sergio Oliveira de Paula; Rafael Freitas de Oliveira Franca
Journal:  Viruses       Date:  2022-05-05       Impact factor: 5.818

Review 3.  Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors.

Authors:  Sineewanlaya Wichit; Nuttamonpat Gumpangseth; Rodolphe Hamel; Sakda Yainoy; Siwaret Arikit; Chuchard Punsawad; Dorothée Missé
Journal:  Pathogens       Date:  2021-04-09

4.  Inhibition of Chikungunya Virus Infection by 4-Hydroxy-1-Methyl-3-(3-morpholinopropanoyl)quinoline-2(1H)-one (QVIR) Targeting nsP2 and E2 Proteins.

Authors:  Mohammad Islamuddin; Obaid Afzal; Wajihul Hasan Khan; Malik Hisamuddin; Abdulmalik Saleh Alfawaz Altamimi; Ibraheem Husain; Kentaro Kato; Mubarak A Alamri; Shama Parveen
Journal:  ACS Omega       Date:  2021-03-31

Review 5.  Demystifying therapeutic potential of medicinal plants against chikungunya virus.

Authors:  Sukender Kumar; Chanchal Garg; Samander Kaushik; Harpal Singh Buttar; Munish Garg
Journal:  Indian J Pharmacol       Date:  2021 Sep-Oct       Impact factor: 1.200

6.  CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251.

Authors:  Friederike I L Hucke; Malena Bestehorn-Willmann; Marcella Bassetto; Andrea Brancale; Paola Zanetta; Joachim J Bugert
Journal:  Virus Genes       Date:  2022-03-26       Impact factor: 2.198

7.  The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication.

Authors:  Lucca R Policastro; Isabela Dolci; Andre S Godoy; José V J Silva Júnior; Uriel E A Ruiz; Igor A Santos; Ana C G Jardim; Kirandeep Samby; Jeremy N Burrows; Timothy N C Wells; Laura H V G Gil; Glaucius Oliva; Rafaela S Fernandes
Journal:  Viruses       Date:  2022-06-21       Impact factor: 5.818
  7 in total

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