Literature DB >> 33378272

ARDD 2020: from aging mechanisms to interventions.

Garik V Mkrtchyan1, Kotb Abdelmohsen2, Pénélope Andreux3, Ieva Bagdonaite4, Nir Barzilai5,6, Søren Brunak7, Filipe Cabreiro8, Rafael de Cabo9, Judith Campisi10, Ana Maria Cuervo11, Marco Demaria12, Collin Y Ewald13, Evandro Fei Fang14, Richard Faragher15, Luigi Ferrucci16, Adam Freund17, Carlos G Silva-García18, Anastasia Georgievskaya19, Vadim N Gladyshev20, David J Glass21, Vera Gorbunova22, Aubrey de Grey23, Wei-Wu He24, Jan Hoeijmakers25, Eva Hoffmann26, Steve Horvath27, Riekelt H Houtkooper28, Majken K Jensen29, Martin Borch Jensen30, Alice Kane31, Moustapha Kassem32, Peter de Keizer33, Brian Kennedy10,34,35, Gerard Karsenty36, Dudley W Lamming37, Kai-Fu Lee38, Nanna MacAulay39, Polina Mamoshina40, Jim Mellon41, Marte Molenaars28, Alexey Moskalev42, Andreas Mund7, Laura Niedernhofer43, Brenna Osborne1, Heidi H Pak37, Andrey Parkhitko44, Nuno Raimundo45, Thomas A Rando46, Lene Juel Rasmussen1, Carolina Reis47, Christian G Riedel48, Anais Franco-Romero49, Björn Schumacher50, David A Sinclair31,51, Yousin Suh52, Pam R Taub53, Debra Toiber54, Jonas T Treebak55, Dario Riccardo Valenzano56, Eric Verdin10, Jan Vijg5, Sergey Young57, Lei Zhang43, Daniela Bakula1, Alex Zhavoronkov58, Morten Scheibye-Knudsen1.   

Abstract

Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting, held online on the 1st to 4th of September 2020. The meeting covered topics related to new methodologies to study aging, knowledge about basic mechanisms of longevity, latest interventional strategies to target the aging process as well as discussions about the impact of aging research on society and economy. More than 2000 participants and 65 speakers joined the meeting and we already look forward to an even larger meeting next year. Please mark your calendars for the 8th ARDD meeting that is scheduled for the 31st of August to 3rd of September, 2021, at Columbia University, USA.

Entities:  

Keywords:  aging; artificial intelligence; drug discovery; interventions

Mesh:

Substances:

Year:  2020        PMID: 33378272      PMCID: PMC7803558          DOI: 10.18632/aging.202454

Source DB:  PubMed          Journal:  Aging (Albany NY)        ISSN: 1945-4589            Impact factor:   5.682


  107 in total

Review 1.  Signal Transduction, Ageing and Disease.

Authors:  Lei Zhang; Matthew J Yousefzadeh; Yousin Suh; Laura J Niedernhofer; Paul D Robbins
Journal:  Subcell Biochem       Date:  2019

2.  Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

Authors:  Dongryeol Ryu; Laurent Mouchiroud; Pénélope A Andreux; Elena Katsyuba; Norman Moullan; Amandine A Nicolet-Dit-Félix; Evan G Williams; Pooja Jha; Giuseppe Lo Sasso; Damien Huzard; Patrick Aebischer; Carmen Sandi; Chris Rinsch; Johan Auwerx
Journal:  Nat Med       Date:  2016-07-11       Impact factor: 53.440

3.  Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A.

Authors:  Cheryl A Conover; Laurie K Bale; Jessica R Mader; Megan A Mason; Kevin P Keenan; Ronald J Marler
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-03-29       Impact factor: 6.053

4.  Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health.

Authors:  Luigi Fontana; Nicole E Cummings; Sebastian I Arriola Apelo; Joshua C Neuman; Ildiko Kasza; Brian A Schmidt; Edda Cava; Francesco Spelta; Valeria Tosti; Faizan A Syed; Emma L Baar; Nicola Veronese; Sara E Cottrell; Rachel J Fenske; Beatrice Bertozzi; Harpreet K Brar; Terri Pietka; Arnold D Bullock; Robert S Figenshau; Gerald L Andriole; Matthew J Merrins; Caroline M Alexander; Michelle E Kimple; Dudley W Lamming
Journal:  Cell Rep       Date:  2016-06-23       Impact factor: 9.423

5.  Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.

Authors:  Siming Ma; Sun Hee Yim; Sang-Goo Lee; Eun Bae Kim; Sang-Rae Lee; Kyu-Tae Chang; Rochelle Buffenstein; Kaitlyn N Lewis; Thomas J Park; Richard A Miller; Clary B Clish; Vadim N Gladyshev
Journal:  Cell Metab       Date:  2015-08-04       Impact factor: 27.287

6.  Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome.

Authors:  Michel Bernier; Dylan Harney; Yen Chin Koay; Antonio Diaz; Abhishek Singh; Devin Wahl; Tamara Pulpitel; Ahmed Ali; Vince Guiterrez; Sarah J Mitchell; Eun-Young Kim; John Mach; Nathan L Price; Miguel A Aon; David G LeCouteur; Victoria C Cogger; Carlos Fernandez-Hernando; John O'Sullivan; Mark Larance; Ana Maria Cuervo; Rafael de Cabo
Journal:  NPJ Aging Mech Dis       Date:  2020-07-21

7.  Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology.

Authors:  Tea Shavlakadze; Jiang Zhu; Sharon Wang; Weihua Zhou; Bret Morin; Marc A Egerman; Lin Fan; Yanqun Wang; Oleg Iartchouk; Angelika Meyer; Reginald A Valdez; Joan B Mannick; Lloyd B Klickstein; David J Glass
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2018-06-14       Impact factor: 6.053

8.  The Role of Muscle Perfusion in the Age-Associated Decline of Mitochondrial Function in Healthy Individuals.

Authors:  Fatemeh Adelnia; Donnie Cameron; Christopher M Bergeron; Kenneth W Fishbein; Richard G Spencer; David A Reiter; Luigi Ferrucci
Journal:  Front Physiol       Date:  2019-04-12       Impact factor: 4.566

9.  Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging.

Authors:  Georges E Janssens; Xin-Xuan Lin; Lluís Millan-Ariño; Alan Kavšek; Ilke Sen; Renée I Seinstra; Nicholas Stroustrup; Ellen A A Nollen; Christian G Riedel
Journal:  Cell Rep       Date:  2019-04-09       Impact factor: 9.423

10.  Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease.

Authors:  Jakob M Bader; Philipp E Geyer; Johannes B Müller; Maximilian T Strauss; Manja Koch; Frank Leypoldt; Peter Koertvelyessy; Daniel Bittner; Carola G Schipke; Enise I Incesoy; Oliver Peters; Nikolaus Deigendesch; Mikael Simons; Majken K Jensen; Henrik Zetterberg; Matthias Mann
Journal:  Mol Syst Biol       Date:  2020-06       Impact factor: 11.429

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  5 in total

1.  Human organ rejuvenation by VEGF-A: Lessons from the skin.

Authors:  Aviad Keren; Marta Bertolini; Yaniv Keren; Yehuda Ullmann; Ralf Paus; Amos Gilhar
Journal:  Sci Adv       Date:  2022-06-24       Impact factor: 14.957

Review 2.  A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease.

Authors:  Huiyi Chen; Feng Chen; Ying Jiang; Lu Zhang; Guizhen Hu; Furong Sun; Miaoping Zhang; Yao Ji; Yanting Chen; Gang Che; Xu Zhou; Yu Zhang
Journal:  Front Aging Neurosci       Date:  2022-05-20       Impact factor: 5.702

Review 3.  "Reframing" dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications.

Authors:  Bianca Marchetti; Carmela Giachino; Cataldo Tirolo; Maria F Serapide
Journal:  Aging Cell       Date:  2022-03-09       Impact factor: 9.304

Review 4.  Ageing and cancer: a research gap to fill.

Authors:  Eric Solary; Nancy Abou-Zeid; Fabien Calvo
Journal:  Mol Oncol       Date:  2022-05-21       Impact factor: 7.449

5.  Searching for female reproductive aging and longevity biomarkers.

Authors:  Svetlana Yureneva; Viktoriya Averkova; Denis Silachev; Andrey Donnikov; Alla Gavisova; Vladimir Serov; Gennady Sukhikh
Journal:  Aging (Albany NY)       Date:  2021-06-22       Impact factor: 5.682

  5 in total

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