| Literature DB >> 33371014 |
Dora Inés Parra1,2, Isabel Trapero Gimeno3, Javier Mauricio Sánchez Rodríguez4, Lizeth Catherine Rodríguez Corredor5,6, Juliana Alexandra Hernández Vargas7, Luis Alberto López Romero8, Fernando J García López9, Cristina Escudero-Gómez10, Silvia Juliana Trujillo-Cáceres7, Pilar Serrano-Gallardo11, Lina M Vera-Cala6.
Abstract
INTRODUCTION: Hypertension is a chronic disease with 31% worldwide prevalence in adults. It has been associated with non-adherence to therapeutic regime with a negative impact on the prognosis of the disease and healthcare-associated costs. So, it is necessary to identify effective interventions to improve adherence among the afflicted population. The objective of this protocol is to describe the methods for a systematic review that will evaluate the effect of individual interventions so as to improve adherence to the prescribed pharmacological treatment, as well as to prescribed diet and physical activity in adults with primary hypertension. METHODS AND ANALYSIS: A systematic search of studies will be conducted in PubMed/MEDLINE, BVS, CINAHL, Embase, Cochrane and Scopus databases. Randomised and non-randomised clinical studies conducted in human beings, published from 1 January 2009 to 13 December 2019, are to be included, in any language. Adherence to pharmacological treatment, diet and physical activity, measured by direct and indirect methods, will be the primary outcome. Two independent reviewers will select relevant studies and will extract the data following the Cochrane's Handbook for Systematic Reviews of Approach and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. Methodological quality will be evaluated using the risk-of-bias (RoB) 2 and Risk of Bias in Non-randomised Studies - of Interventions (ROBINS-I) tools. Risk of bias will also be evaluated, and if the criteria are met, a meta-analysis will be finally performed. ETHICS AND DISSEMINATION: Information to be analysed is of a grouped nature, and given that its sources are published studies, no ethics committee approval is required. Results will be published in scientific journals, and in conferences, seminars and symposiums. Copyrights will be addressed by giving due credit through bibliographic references. PROSPERO REGISTRATION NUMBER: CRD42020147655. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.Entities:
Keywords: epidemiology; hypertension; nutrition & dietetics; primary care; public health
Mesh:
Substances:
Year: 2020 PMID: 33371014 PMCID: PMC7757507 DOI: 10.1136/bmjopen-2020-037920
Source DB: PubMed Journal: BMJ Open ISSN: 2044-6055 Impact factor: 2.692
Direct and indirect methods reported in literature to evaluate adherence to therapeutic regime
| Pharmacological treatment | Diet | Prescribed physical activity |
| Tablet counting | Degree of adherence to DASH diet | Accelerometry changes |
| Questionnaires (Morisky-Green, MARS, SMAQ) | Anthropometric changes (BMI, WHI) | |
Medication-contained electronic microchip Electronic monitors of medication Rates of prescription refills Measure of clinical response or physiological markers Patient’s diaries | Lipid profile changes | |
| Concentration of pharmaceutical or its metabolite in bodily fluids (blood, urine) | Strain test | |
| Directly observed therapy | Six-minute walk test | |
BMI, Body Mass Index; DASH, Dietary Approaches to Stop Hypertension; MARS, Medication Adherence Report Scale; SMAQ, Simplified Medication Adherence Questionnaire; WHI, Waist-Hip Index.
Search strategy PICOT
| Participants/Patients (P) | Intervention (I) | Outcomes (O) | Type of studio (T) | |
| Pharmacological treatment | ((((“Essential hypertension”(MeSH Terms] OR HTN(Title/Abstract)) OR Primary Hypertension(Title/Abstract)) OR “hypertension”(MeSH Terms)) OR Hypertension(Title/Abstract)) NOT (“animals”(MeSH Terms] NOT (“animals”(MeSH] AND “humans”(MeSH Terms))) | (“Education”(Mesh)) OR “Health Education”(Mesh)) OR “Patient Education as Topic”(Mesh)) OR “Program Evaluation”(Mesh] OR intervention*(tiab] OR educat*(tiab] OR prevent*(tiab] OR “Behavior therapy”(Mesh] OR “Mentoring”(Mesh] OR behaviour therapy [tiab) | “Treatment Adherence and Compliance”(Mesh] OR Adherence(tiab] OR compliance(tiab] OR Nonadherence(tiab] OR Noncompliance(tiab] OR Non- Adherence(tiab] OR Non- Compliance(tiab] OR medication intake adherence(tiab] OR drug therap*(tiab] OR medication therapy management(tiab) | Clinical Query de Pubmed: ((clinical(Title/Abstract)AND trial(Title/Abstract)) OR clinical trials as topic [MeSH Terms] OR clinical trial(Publication Type] OR random*(Title/Abstract)OR random allocation(MeSH Terms] OR therapeutic use(MeSH Subheading)) |
| Diet | ((((“Essential hypertension”(MeSH Terms] OR HTN(Title/Abstract)) OR Primary Hypertension(Title/Abstract)) OR “hypertension”(MeSH Terms)) OR Hypertension(Title/Abstract)) NOT (“animals”(MeSH Terms] NOT (“animals”(MeSH] AND “humans”(MeSH Terms))) | (“Education”(Mesh)) OR “Health Education”(Mesh)) OR “Patient Education as Topic”(Mesh)) OR “Program Evaluation”(Mesh] OR intervention*(tiab] OR educat*(tiab] OR prevent*(tiab] OR “Behavior therapy”(Mesh] OR “Mentoring”(Mesh] OR behaviour therapy [tiab) | “Diet” [MeSH] OR diet [tiab] OR dietar*(tiab] OR food*(tiab] OR nutrition*(tiab) | Clinical Query de Pubmed: ((clinical(Title/Abstract)AND trial(Title/Abstract)) OR clinical trials as topic [MeSH Terms] OR clinical trial [Publication Type] OR random*(Title/Abstract)OR random allocation(MeSH Terms] OR therapeutic use(MeSH Subheading)) |
| Exercise | ((((“Essential hypertension”(MeSH Terms] OR HTN(Title/Abstract)) OR Primary Hypertension(Title/Abstract)) OR “hypertension”(MeSH Terms)) OR Hypertension(Title/Abstract)) NOT (“animals”(MeSH Terms] NOT (“animals”(MeSH] AND “humans”(MeSH Terms))) | (“Education”(Mesh)) OR “Health Education”(Mesh)) OR “Patient Education as Topic”(Mesh)) OR “Program Evaluation”(Mesh] OR intervention*(tiab] OR educat*(tiab] OR prevent*(tiab] OR “Behavior therapy”(Mesh] OR “Mentoring”(Mesh] OR behaviour therapy [tiab) | “Exercise” [MeSH] OR Exercise*(tiab] OR Physical Activit*(tiab) | Clinical Query de Pubmed: ((clinical(Title/Abstract)AND trial(Title/Abstract)) OR clinical trials as topic [MeSH Terms] OR clinical trial [Publication Type] OR random*(Title/Abstract)OR random allocation(MeSH Terms] OR therapeutic use(MeSH Subheading)) |
Filters: publication date from 1 January 2009 to 13 December 2019.
Figure 1Systematic review flow chart.