Mahboobeh Mahdavinia1, Mary C Tobin2, Jamie L Fierstein3, Aame B Andy-Nweye2, Lucy A Bilaver3, Susan Fox2, Andrea A Pappalardo4, Jialing Jiang3, Perry A Catlin5, Annika Chura5, Adam Robinson6, Iman Abdikarim6, Amaziah Coleman6, Christopher M Warren7, Pamela J Newmark3, Alexandria Bozen3, Olivia R Negris3, Jacqueline A Pongracic7, Hemant P Sharma6, Amal H Assa'ad5, Ruchi S Gupta8. 1. Division of Allergy/Immunology, Rush University Medical Center, Chicago, Ill. Electronic address: Mahboobeh_mahdavinia@rush.edu. 2. Division of Allergy/Immunology, Rush University Medical Center, Chicago, Ill. 3. Center for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. 4. Department of Medicine and Pediatrics, University of Illinois at Chicago, Chicago, Ill. 5. Division of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. 6. Division of Allergy and Immunology, Children's National Health Systems, Washington, DC. 7. Advanced General Pediatrics and Primary Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill. 8. Center for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill; Advanced General Pediatrics and Primary Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Abstract
BACKGROUND: Despite major differences in health profiles and rates of health care utilization between African American and White children with food allergy (FA), the detailed phenotypic variables that can potentially impact these outcomes have not been thoroughly studied. OBJECTIVE: We aimed to characterize phenotypic differences such as allergies to different foods and allergic comorbidities between African American and White children with FA enrolled in the Food Allergy Outcomes Related to White and African American Racial Differences study. METHODS: Our active, prospective, multicenter cohort study is currently enrolling African American and White children aged 0 to 12 years diagnosed with FA and followed by allergy/immunology clinics at 4 urban tertiary centers in the United States. To evaluate associations between race and phenotypic variables, we used multivariable logistic regression, adjusting for important demographic and confounding factors, as well as potential household clustering. RESULTS: As of May 2020, there were 239 African Americans and 425 Whites with complete intake information enrolled in the study. In comparison with Whites, we found that African Americans had significantly higher adjusted odds of allergy to finfish (odds ratio [OR]: 2.54, P < .01) and shellfish (OR: 3.10, P < .001). African Americans also had higher adjusted odds of asthma than Whites (asthma prevalence of 60.5% in African Americans and 27.2% in Whites; OR: 2.70, P < .001). In addition, shellfish allergy was associated with asthma, after controlling for race. CONCLUSION: Among a diverse cohort of children with physician-diagnosed FA, we observed that African American children had higher odds of allergy to shellfish and finfish, and higher rates of asthma. Interestingly, having asthma was independently associated with allergy to shellfish, after controlling for race.
BACKGROUND: Despite major differences in health profiles and rates of health care utilization between African American and White children with food allergy (FA), the detailed phenotypic variables that can potentially impact these outcomes have not been thoroughly studied. OBJECTIVE: We aimed to characterize phenotypic differences such as allergies to different foods and allergic comorbidities between African American and White children with FA enrolled in the Food Allergy Outcomes Related to White and African American Racial Differences study. METHODS: Our active, prospective, multicenter cohort study is currently enrolling African American and White children aged 0 to 12 years diagnosed with FA and followed by allergy/immunology clinics at 4 urban tertiary centers in the United States. To evaluate associations between race and phenotypic variables, we used multivariable logistic regression, adjusting for important demographic and confounding factors, as well as potential household clustering. RESULTS: As of May 2020, there were 239 African Americans and 425 Whites with complete intake information enrolled in the study. In comparison with Whites, we found that African Americans had significantly higher adjusted odds of allergy to finfish (odds ratio [OR]: 2.54, P < .01) and shellfish (OR: 3.10, P < .001). African Americans also had higher adjusted odds of asthma than Whites (asthma prevalence of 60.5% in African Americans and 27.2% in Whites; OR: 2.70, P < .001). In addition, shellfish allergy was associated with asthma, after controlling for race. CONCLUSION: Among a diverse cohort of children with physician-diagnosed FA, we observed that African American children had higher odds of allergy to shellfish and finfish, and higher rates of asthma. Interestingly, having asthma was independently associated with allergy to shellfish, after controlling for race.
Authors: Andrew H Liu; Renee Jaramillo; Scott H Sicherer; Robert A Wood; S Allan Bock; A Wesley Burks; Mark Massing; Richard D Cohn; Darryl C Zeldin Journal: J Allergy Clin Immunol Date: 2010-10 Impact factor: 10.793
Authors: D L Rosenstreich; P Eggleston; M Kattan; D Baker; R G Slavin; P Gergen; H Mitchell; K McNiff-Mortimer; H Lynn; D Ownby; F Malveaux Journal: N Engl J Med Date: 1997-05-08 Impact factor: 91.245
Authors: Thimo Ruethers; Aya C Taki; Roni Nugraha; Trúc T Cao; Martina Koeberl; Sandip D Kamath; Nicholas A Williamson; Sean O'Callaghan; Shuai Nie; Sam S Mehr; Dianne E Campbell; Andreas L Lopata Journal: Allergy Date: 2019-04-15 Impact factor: 13.146
Authors: Mahboobeh Mahdavinia; Susan R Fox; Bridget M Smith; Christine James; Erica L Palmisano; Aisha Mohammed; Zeeshan Zahid; Amal H Assa'ad; Mary C Tobin; Ruchi S Gupta Journal: J Allergy Clin Immunol Pract Date: 2016-11-23
Authors: Mahboobeh Mahdavinia; Lucy A Bilaver; Susan Fox; Andrea A Pappalardo; Aame B Andy-Nweye; Hemant P Sharma; Amal H Assa'ad; Ruchi S Gupta; Mary C Tobin Journal: J Allergy Clin Immunol Pract Date: 2021-10-19
Authors: Audrey G Brewer; Jialing Jiang; Christopher M Warren; Hemant P Sharma; Mary C Tobin; Amal Assa'ad; Ruchi S Gupta Journal: J Allergy Clin Immunol Pract Date: 2021-10-22
Authors: Andrea A Pappalardo; Linda Herbert; Christopher Warren; Lisa Lombard; Ashley Ramos; Amal Asa'ad; Hemant Sharma; Mary C Tobin; Jonathan Choi; Haley Hultquist; Jialing Jiang; Ashwin Kulkarni; Mahboobeh Mahdavinia; Eileen Vincent; Ruchi Gupta Journal: J Pediatr Psychol Date: 2022-06-07