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Literature DB >> 3335481

Gene organization and structure of the Streptomyces lividans gal operon.

C W Adams¹, J A Fornwald, F J Schmidt, M Rosenberg, M E Brawner.

Abstract

We present the gene organization and DNA sequence of the Streptomyces lividans galactose utilization genes. Complementation of Escherichia coli galE, galT, or galK mutants and DNA sequence analysis were used to demonstrate that the galactose utilization genes are organized within an operon with the gene order galT, galE, and galK. Comparison of the inferred protein sequences for the S. lividans gal gene products to the corresponding E. coli and Saccharomyces carlbergensis sequences identified regions of structural homology within each of the galactose utilization enzymes. Finally, we discuss a potential relationship between the gene organization of the operon and the functional roles of the gal enzymes in cellular metabolism.

Entities: Chemical Species

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Year: 1988 PMID： 3335481 PMCID： PMC210627 DOI： 10.1128/jb.170.1.203-212.1988

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

44 in total

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Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

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Journal: Nat New Biol Date: 1973-11-14

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Journal: Genetics Date: 1969-06 Impact factor: 4.562

6. Cloning and characterization of EcoRI and HindIII restriction endonuclease-generated fragments of antibiotic resistance plasmids R6-5 and R6.

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Journal: Mol Gen Genet Date: 1978-06-14

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Journal: J Virol Date: 1972-02 Impact factor: 5.103

10. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

24 in total

1. A complex insertion sequence cluster at a point of interaction between the linear plasmid SCP1 and the linear chromosome of Streptomyces coelicolor A3(2).

Authors: M Yamasaki; K Miyashita; J Cullum; H Kinashi
Journal: J Bacteriol Date: 2000-06 Impact factor: 3.490

2. Isolation and characterization of a subsurface bacterium capable of growth on toluene, naphthalene, and other aromatic compounds.

Authors: J K Fredrickson; F J Brockman; D J Workman; S W Li; T O Stevens
Journal: Appl Environ Microbiol Date: 1991-03 Impact factor: 4.792

Review 3. Streptomyces cloning: possible construction of novel compounds and regulation of antibiotic biosynthetic genes.

Authors: P K Tomich
Journal: Antimicrob Agents Chemother Date: 1988-10 Impact factor: 5.191

Review 4. The impact of genetic engineering on the commercial production of antibiotics by Streptomyces and related bacteria.

Authors: C R Hutchinson
Journal: Appl Biochem Biotechnol Date: 1987 Sep-Dec Impact factor: 2.926

5. Conservation of short patches of amino acid sequence amongst proteins with a common function but evolutionarily distinct origins: implications for cloning genes and for structure-function analysis.

Authors: J K Reichardt; P Berg
Journal: Nucleic Acids Res Date: 1988-09-26 Impact factor: 16.971

6. Genetics of streptomycin production in Streptomyces griseus: molecular structure and putative function of genes strELMB2N.

Authors: K Pissowotzki; K Mansouri; W Piepersberg
Journal: Mol Gen Genet Date: 1991-12

7. A genetic factor for age-related cataract: identification and characterization of a novel galactokinase variant, "Osaka," in Asians.

Authors: Y Okano; M Asada; A Fujimoto; A Ohtake; K Murayama; K J Hsiao; K Choeh; Y Yang; Q Cao; J K Reichardt; S Niihira; T Imamura; T Yamano
Journal: Am J Hum Genet Date: 2001-02-23 Impact factor: 11.025

8. Identification of a complex operator for galP1, the glucose-sensitive, galactose-dependent promoter of the Streptomyces galactose operon.

Authors: S G Mattern; M E Brawner; J Westpheling
Journal: J Bacteriol Date: 1993-03 Impact factor: 3.490

9. In silico and transcriptional analysis of carbohydrate uptake systems of Streptomyces coelicolor A3(2).

Authors: Ralph Bertram; Maximilian Schlicht; Kerstin Mahr; Harald Nothaft; Milton H Saier; Fritz Titgemeyer
Journal: J Bacteriol Date: 2004-03 Impact factor: 3.490

10. Complete nucleotide sequence and molecular characterization of ViaB region encoding Vi antigen in Salmonella typhi.

Authors: Y Hashimoto; N Li; H Yokoyama; T Ezaki
Journal: J Bacteriol Date: 1993-07 Impact factor: 3.490