| Literature DB >> 33352085 |
Elena Pérez-Nadales, Ana Alastruey-Izquierdo, María José Linares-Sicilia, Juan Carlos Soto-Debrán, Edson Abdala, Julio García-Rodríguez, Miguel Montejo, Patricia Muñoz, Miguel Salavert Lletí, Antonio Rezusta, Maite Ruiz Pérez de Pipaón, Lucrecia Yáñez, Esperanza Merino, María Isolina Campos-Herrero, José María Costa-Mateo, Jesús Fortún, Tomás García-Lozano, Carolina Garcia-Vidal, Mario Fernández-Ruiz, Ferrán Sánchez-Reus, Carmen Castro-Méndez, Inmaculada Guerrero-Lozano, Pere Soler-Palacín, José María Aguado, Luis Martínez-Martínez, Julian Torre-Cisneros, Marcio Nucci.
Abstract
Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.Entities:
Keywords: Fusarium; Spain; fungal infections; fungi; fusariosis; incidence; invasive fusariosis; mortality; mycotic diseases; neutropenia
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Year: 2021 PMID： 33352085 PMCID： PMC7774531 DOI： 10.3201/eid2701.190782
Source DB: PubMed Journal: Emerg Infect Dis ISSN： 1080-6040 Impact factor: 6.883