Literature DB >> 34543091

Antifungal Susceptibility of 182 Fusarium Species Isolates from 20 European Centers: Comparison between EUCAST and Gradient Concentration Strip Methods.

Marion Blaize1,2, Anne-Cecile Normand1, Sebastien Imbert1, Abdullah M S Al-Hatmi3,4, Erja Chryssanthou5, Sophie Cassaing6, Christine Schuttler7, Lilia Hasseine8, Caroline Mahinc9, Damien Costa10, Christine Bonnal11, Stéphane Ranque12, Marc Sautour13, Elisa Rubio14,15, Laurence Delhaes16, Arnaud Riat17, Boualem Sendid18, Lise Kristensen19, Marcel Brandenberger20, Dirk Stubbe21, Sophie Brun22, Renaud Piarroux1,23, Arnaud Fekkar1,2.   

Abstract

We determined the susceptibility of 182 Fusarium species isolates to five antifungal drugs (amphotericin B, voriconazole, posaconazole, isavuconazole, and terbinafine) by the EUCAST method. Based on the latest taxonomic insights, isolates collected from 20 European centers were distributed into seven complexes and 27 species. The susceptibility was variable, depending on the species. Comparison with the gradient concentration strip method, which was used for 77 isolates, showed essential agreement values for voriconazole, posaconazole, isavuconazole, and amphotericin B of 17%, 91%, 83%, and 70%, respectively.

Entities:  

Keywords:  EUCAST; Etest; Fusarium; amphotericin B; antifungal susceptibility; comparison; gradient concentration strips; isavuconazole; posaconazole; terbinafine; voriconazole

Mesh：

Substances：

Year:  2021        PMID： 34543091      PMCID： PMC8597759          DOI： 10.1128/AAC.01495-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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9.  Clinical Origin and Species Distribution of Fusarium spp. Isolates Identified by Molecular Sequencing and Mass Spectrometry: A European Multicenter Hospital Prospective Study.

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