Literature DB >> 33350925

Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda.

Clara Bergmann, Welmoed van Loon, Felix Habarugira, Costanza Tacoli, Julia C Jäger, Darius Savelsberg, Fabian Nshimiyimana, Elias Rwamugema, Djibril Mbarushimana, Jules Ndoli, Augustin Sendegeya, Claude Bayingana, Frank P Mockenhaupt.   

Abstract

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.

Entities:  

Keywords:  Kelch; Plasmodium falciparum; antimicrobial resistance; artemisinin; malaria; mutation; parasites; polymorphism; vector-borne infections

Mesh：

Substances：

Year:  2021        PMID： 33350925      PMCID： PMC7774571          DOI： 10.3201/eid2701.203527

Source DB:  PubMed          Journal:  Emerg Infect Dis        ISSN： 1080-6040            Impact factor:   6.883


  12 in total

1.  Expanding home-based management of malaria to all age groups in Rwanda: analysis of acceptability and facility-level time-series data.

Authors:  Aline Uwimana; Michael J Penkunas; Marie Paul Nisingizwe; Didier Uyizeye; Dieudonne Hakizimana; Clarisse Musanabaganwa; Jean Pierre Musabyimana; Alida Ngwije; Innocent Turate; Aimable Mbituyumuremyi; Monique Murindahabi; Jeanine Condo
Journal:  Trans R Soc Trop Med Hyg       Date:  2018-11-01       Impact factor: 2.184

2.  A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.

Authors:  Frédéric Ariey; Benoit Witkowski; Chanaki Amaratunga; Johann Beghain; Anne-Claire Langlois; Nimol Khim; Saorin Kim; Valentine Duru; Christiane Bouchier; Laurence Ma; Pharath Lim; Rithea Leang; Socheat Duong; Sokunthea Sreng; Seila Suon; Char Meng Chuor; Denis Mey Bout; Sandie Ménard; William O Rogers; Blaise Genton; Thierry Fandeur; Olivo Miotto; Pascal Ringwald; Jacques Le Bras; Antoine Berry; Jean-Christophe Barale; Rick M Fairhurst; Françoise Benoit-Vical; Odile Mercereau-Puijalon; Didier Ménard
Journal:  Nature       Date:  2013-12-18       Impact factor: 49.962

3.  The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda.

Authors:  Melissa D Conrad; Sam L Nsobya; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

4.  Artemisinin Resistance-Associated K13 Polymorphisms of Plasmodium falciparum in Southern Rwanda, 2010-2015.

Authors:  Costanza Tacoli; Prabhanjan P Gai; Claude Bayingana; Kevin Sifft; Dominik Geus; Jules Ndoli; Augustin Sendegeya; Jean Bosco Gahutu; Frank P Mockenhaupt
Journal:  Am J Trop Med Hyg       Date:  2016-08-29       Impact factor: 2.345

5.  Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort.

Authors:  Ricardo Ataide; Elizabeth A Ashley; Rosanna Powell; Jo-Anne Chan; Michael J Malloy; Katherine O'Flaherty; Eizo Takashima; Christine Langer; Takafumi Tsuboi; Arjen M Dondorp; Nicholas P Day; Mehul Dhorda; Rick M Fairhurst; Pharath Lim; Chanaki Amaratunga; Sasithon Pukrittayakamee; Tran Tinh Hien; Ye Htut; Mayfong Mayxay; M Abul Faiz; James G Beeson; Francois Nosten; Julie A Simpson; Nicholas J White; Freya J I Fowkes
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-13       Impact factor: 11.205

6.  A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.

Authors:  Didier Ménard; Nimol Khim; Johann Beghain; Ayola A Adegnika; Mohammad Shafiul-Alam; Olukemi Amodu; Ghulam Rahim-Awab; Céline Barnadas; Antoine Berry; Yap Boum; Maria D Bustos; Jun Cao; Jun-Hu Chen; Louis Collet; Liwang Cui; Garib-Das Thakur; Alioune Dieye; Djibrine Djallé; Monique A Dorkenoo; Carole E Eboumbou-Moukoko; Fe-Esperanza-Caridad J Espino; Thierry Fandeur; Maria-Fatima Ferreira-da-Cruz; Abebe A Fola; Hans-Peter Fuehrer; Abdillahi M Hassan; Socrates Herrera; Bouasy Hongvanthong; Sandrine Houzé; Maman L Ibrahim; Mohammad Jahirul-Karim; Lubin Jiang; Shigeyuki Kano; Wasif Ali-Khan; Maniphone Khanthavong; Peter G Kremsner; Marcus Lacerda; Rithea Leang; Mindy Leelawong; Mei Li; Khin Lin; Jean-Baptiste Mazarati; Sandie Ménard; Isabelle Morlais; Hypolite Muhindo-Mavoko; Lise Musset; Kesara Na-Bangchang; Michael Nambozi; Karamoko Niaré; Harald Noedl; Jean-Bosco Ouédraogo; Dylan R Pillai; Bruno Pradines; Bui Quang-Phuc; Michael Ramharter; Milijaona Randrianarivelojosia; Jetsumon Sattabongkot; Abdiqani Sheikh-Omar; Kigbafori D Silué; Sodiomon B Sirima; Colin Sutherland; Din Syafruddin; Rachida Tahar; Lin-Hua Tang; Offianan A Touré; Patrick Tshibangu-wa-Tshibangu; Inès Vigan-Womas; Marian Warsame; Lyndes Wini; Sedigheh Zakeri; Saorin Kim; Rotha Eam; Laura Berne; Chanra Khean; Sophy Chy; Malen Ken; Kaknika Loch; Lydie Canier; Valentine Duru; Eric Legrand; Jean-Christophe Barale; Barbara Stokes; Judith Straimer; Benoit Witkowski; David A Fidock; Christophe Rogier; Pascal Ringwald; Frederic Ariey; Odile Mercereau-Puijalon
Journal:  N Engl J Med       Date:  2016-06-23       Impact factor: 91.245

7.  Prevalence and risk factors of malaria among children in southern highland Rwanda.

Authors:  Jean-Bosco Gahutu; Christian Steininger; Cyprien Shyirambere; Irene Zeile; Neniling Cwinya-Ay; Ina Danquah; Christoph H Larsen; Teunis A Eggelte; Aline Uwimana; Corine Karema; Andre Musemakweri; Gundel Harms; Frank P Mockenhaupt
Journal:  Malar J       Date:  2011-05-18       Impact factor: 2.979

Review 8.  The threat of antimalarial drug resistance.

Authors:  Borimas Hanboonkunupakarn; Nicholas J White
Journal:  Trop Dis Travel Med Vaccines       Date:  2016-07-07

9.  Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014-2016.

Authors:  Mie Ikeda; Megumi Kaneko; Shin-Ichiro Tachibana; Betty Balikagala; Miki Sakurai-Yatsushiro; Shouki Yatsushiro; Nobuyuki Takahashi; Masato Yamauchi; Makoto Sekihara; Muneaki Hashimoto; Osbert T Katuro; Alex Olia; Paul S Obwoya; Mary A Auma; Denis A Anywar; Emmanuel I Odongo-Aginya; Joseph Okello-Onen; Makoto Hirai; Jun Ohashi; Nirianne M Q Palacpac; Masatoshi Kataoka; Takafumi Tsuboi; Eisaku Kimura; Toshihiro Horii; Toshihiro Mita
Journal:  Emerg Infect Dis       Date:  2018-04       Impact factor: 6.883

10.  Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.

Authors:  Aline Uwimana; Eric Legrand; Barbara H Stokes; Jean-Louis Mangala Ndikumana; Marian Warsame; Noella Umulisa; Daniel Ngamije; Tharcisse Munyaneza; Jean-Baptiste Mazarati; Kaendi Munguti; Pascal Campagne; Alexis Criscuolo; Frédéric Ariey; Monique Murindahabi; Pascal Ringwald; David A Fidock; Aimable Mbituyumuremyi; Didier Menard
Journal:  Nat Med       Date:  2020-08-03       Impact factor: 53.440
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  19 in total

1.  Prevalence of arps10, fd, pfmdr-2, pfcrt and pfkelch13 gene mutations in Plasmodium falciparum parasite population in Uganda.

Authors:  Moses Ocan; Fred Katabazi Ashaba; Savannah Mwesigwa; Kigozi Edgar; Moses R Kamya; Sam L Nsobya
Journal:  PLoS One       Date:  2022-05-05       Impact factor: 3.752

2.  Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.

Authors:  Stanley C Xie; Riley D Metcalfe; Hirotake Mizutani; Tanya Puhalovich; Eric Hanssen; Craig J Morton; Yawei Du; Con Dogovski; Shih-Chung Huang; Jeffrey Ciavarri; Paul Hales; Robert J Griffin; Lawrence H Cohen; Bei-Ching Chuang; Sergio Wittlin; Ioanna Deni; Tomas Yeo; Kurt E Ward; Daniel C Barry; Boyin Liu; David L Gillett; Benigno F Crespo-Fernandez; Sabine Ottilie; Nimisha Mittal; Alisje Churchyard; Daniel Ferguson; Anna Caroline C Aguiar; Rafael V C Guido; Jake Baum; Kirsten K Hanson; Elizabeth A Winzeler; Francisco-Javier Gamo; David A Fidock; Delphine Baud; Michael W Parker; Stephen Brand; Lawrence R Dick; Michael D W Griffin; Alexandra E Gould; Leann Tilley
Journal:  Proc Natl Acad Sci U S A       Date:  2021-09-28       Impact factor: 12.779

3.  Changing Pattern of Plasmodium falciparum pfmdr1 Gene Polymorphisms in Southern Rwanda.

Authors:  Welmoed van Loon; Clara Bergmann; Felix Habarugira; Costanza Tacoli; Darius Savelsberg; Rafael Oliveira; Djibril Mbarushimana; Jules Ndoli; Augustin Sendegeya; Claude Bayingana; Frank P Mockenhaupt
Journal:  Antimicrob Agents Chemother       Date:  2021-08-17       Impact factor: 5.191

4.  Molecular surveillance of pfcrt, pfmdr1 and pfk13-propeller mutations in Plasmodium falciparum isolates imported from Africa to China.

Authors:  Fang Huang; He Yan; Jing-Bo Xue; Yan-Wen Cui; Shui-Sen Zhou; Zhi-Gui Xia; Rabindra Abeyasinghe; Pascal Ringwald; Xiao-Nong Zhou
Journal:  Malar J       Date:  2021-02-06       Impact factor: 2.979

5.  Absence of Association between Methylene Blue Reduced Susceptibility and Polymorphisms in 12 Genes Involved in Antimalarial Drug Resistance in African Plasmodium falciparum.

Authors:  Mathieu Gendrot; Océane Delandre; Marie Gladys Robert; Francis Tsombeng Foguim; Nicolas Benoit; Rémy Amalvict; Isabelle Fonta; Joel Mosnier; Marylin Madamet; Bruno Pradines; On Behalf Of The French National Reference Centre For Imported Malaria Study Group
Journal:  Pharmaceuticals (Basel)       Date:  2021-04-09

6.  To what extent are the antimalarial markets in African countries ready for a transition to triple artemisinin-based combination therapies?

Authors:  Freek de Haan; Oladimeji Akeem Bolarinwa; Rosemonde Guissou; Fatoumata Tou; Paulina Tindana; Wouter P C Boon; Ellen H M Moors; Phaik Yeong Cheah; Mehul Dhorda; Arjen M Dondorp; Jean Bosco Ouedraogo; Olugbenga A Mokuolu; Chanaki Amaratunga
Journal:  PLoS One       Date:  2021-08-31       Impact factor: 3.240

7.  Time to scale up molecular surveillance for anti-malarial drug resistance in sub-saharan Africa.

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Journal:  Malar J       Date:  2021-10-13       Impact factor: 2.979

8.  Molecular surveillance for polymorphisms associated with artemisinin-based combination therapy resistance in Plasmodium falciparum isolates collected in Mozambique, 2018.

Authors:  Arlindo Chidimatembue; Samaly S Svigel; Alfredo Mayor; Pedro Aíde; Abel Nhama; Lídia Nhamussua; Arsénio Nhacolo; Quique Bassat; Crizólgo Salvador; Sónia Enosse; Abuchahama Saifodine; Eva De Carvalho; Baltazar Candrinho; Rose Zulliger; Ira Goldman; Venkatachalam Udhayakumar; Naomi W Lucchi; Eric S Halsey; Eusébio Macete
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Review 9.  The lead-up to epidemic transmission: malaria trends and control interventions in Burundi 2000 to 2019.

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10.  Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.

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