Literature DB >> 34228534

Changing Pattern of Plasmodium falciparum pfmdr1 Gene Polymorphisms in Southern Rwanda.

Welmoed van Loon1, Clara Bergmann1, Felix Habarugira2, Costanza Tacoli1, Darius Savelsberg1, Rafael Oliveira1, Djibril Mbarushimana2, Jules Ndoli2, Augustin Sendegeya2, Claude Bayingana3, Frank P Mockenhaupt1.   

Abstract

Plasmodium falciparum multidrug resistance-1 gene (pfmdr1) polymorphisms associate with altered antimalarial susceptibility. Between 2010 and 2018/2019, we observed that the prevalence of the wild-type allele N86 and the wild-type combination NYD increased 10-fold (4% versus 40%) and more than 2-fold (18% versus 44%), respectively. Haplotypes other than NYD or NFD declined by up to >90%. Our molecular data suggest the pfmdr1 pattern shifted toward one associated with artemether-lumefantrine resistance.

Entities:  

Keywords:  Plasmodium falciparum; Rwanda; malaria; multidrug resistance

Mesh：

Substances：

Year:  2021        PMID： 34228534      PMCID： PMC8370211          DOI： 10.1128/AAC.00901-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Journal:  Trans R Soc Trop Med Hyg       Date:  2018-11-01       Impact factor: 2.184

2.  Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda.

Authors:  Stephen Tukwasibwe; Levi Mugenyi; George W Mbogo; Sheila Nankoberanyi; Catherine Maiteki-Sebuguzi; Moses L Joloba; Samuel L Nsobya; Sarah G Staedke; Philip J Rosenthal
Journal:  J Infect Dis       Date:  2014-01-19       Impact factor: 5.226

3.  High prevalence of pfmdr1 N86Y and Y184F mutations in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea.

Authors:  Jian Li; Jiangtao Chen; Dongde Xie; Santiago-M Monte-Nguba; Juan Urbano Monsuy Eyi; Rocio Apicante Matesa; Maximo Miko Ondo Obono; Carlos Sala Ehapo; Liye Yang; Danjie Lu; Hui Yang; Hui-Tian Yang; Min Lin
Journal:  Pathog Glob Health       Date:  2014-10-27       Impact factor: 2.894

4.  Return of chloroquine antimalarial efficacy in Malawi.

Authors:  Miriam K Laufer; Phillip C Thesing; Nicole D Eddington; Rhoda Masonga; Fraction K Dzinjalamala; Shannon L Takala; Terrie E Taylor; Christopher V Plowe
Journal:  N Engl J Med       Date:  2006-11-09       Impact factor: 91.245

5.  In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

Authors:  Leah Mwai; Steven M Kiara; Abdi Abdirahman; Lewa Pole; Anja Rippert; Abdi Diriye; Pete Bull; Kevin Marsh; Steffen Borrmann; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

6.  Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda.

Authors:  Aimee R Taylor; Jennifer A Flegg; Chris C Holmes; Philippe J Guérin; Carol H Sibley; Melissa D Conrad; Grant Dorsey; Philip J Rosenthal
Journal:  Open Forum Infect Dis       Date:  2016-10-25       Impact factor: 3.835

7.  Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether-lumefantrine and artesunate-amodiaquine in Africa.

Authors:  Lucy C Okell; Lisa Malene Reiter; Lene Sandø Ebbe; Vito Baraka; Donal Bisanzio; Oliver J Watson; Adam Bennett; Robert Verity; Peter Gething; Cally Roper; Michael Alifrangis
Journal:  BMJ Glob Health       Date:  2018-10-19

8.  Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms.

Authors:  Maja Malmberg; Pedro E Ferreira; Joel Tarning; Johan Ursing; Billy Ngasala; Anders Björkman; Andreas Mårtensson; José P Gil
Journal:  J Infect Dis       Date:  2012-12-05       Impact factor: 5.226

Review 9.  The threat of antimalarial drug resistance.

Authors:  Borimas Hanboonkunupakarn; Nicholas J White
Journal:  Trop Dis Travel Med Vaccines       Date:  2016-07-07

10.  Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda.

Authors:  Aline Uwimana; Eric Legrand; Barbara H Stokes; Jean-Louis Mangala Ndikumana; Marian Warsame; Noella Umulisa; Daniel Ngamije; Tharcisse Munyaneza; Jean-Baptiste Mazarati; Kaendi Munguti; Pascal Campagne; Alexis Criscuolo; Frédéric Ariey; Monique Murindahabi; Pascal Ringwald; David A Fidock; Aimable Mbituyumuremyi; Didier Menard
Journal:  Nat Med       Date:  2020-08-03       Impact factor: 53.440
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  1 in total

1.  In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019.

Authors:  Welmoed van Loon; Rafael Oliveira; Clara Bergmann; Felix Habarugira; Jules Ndoli; Augustin Sendegeya; Claude Bayingana; Frank P Mockenhaupt
Journal:  Emerg Infect Dis       Date:  2022-04       Impact factor: 6.883
  1 in total

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