| Literature DB >> 33349681 |
Ana da Silva Filipe1, James G Shepherd1, Thomas Williams2, Joseph Hughes1, Elihu Aranday-Cortes1, Patawee Asamaphan1, Shirin Ashraf1, Carlos Balcazar3, Kirstyn Brunker1, Alasdair Campbell4, Stephen Carmichael1, Chris Davis1, Rebecca Dewar5, Michael D Gallagher6, Rory Gunson7,8, Verity Hill9, Antonia Ho1, Ben Jackson9, Edward James10, Natasha Jesudason1, Natasha Johnson1, E Carol McWilliam Leitch1, Kathy Li1, Alasdair MacLean7, Daniel Mair1, David A McAllister11,12, John T McCrone9, Sarah E McDonald1, Martin P McHugh5,13, A Keith Morris14, Jenna Nichols1, Marc Niebel1, Kyriaki Nomikou1, Richard J Orton1, Áine O'Toole9, Massimo Palmarini1, Benjamin J Parcell15, Yasmin A Parr1, Andrew Rambaut9, Stefan Rooke8, Sharif Shaaban11, Rajiv Shah1, Joshua B Singer1, Katherine Smollett1, Igor Starinskij7, Lily Tong1, Vattipally B Sreenu1, Elizabeth Wastnedge5, Matthew T G Holden11,13, David L Robertson1, Kate Templeton5, Emma C Thomson16,17.
Abstract
Coronavirus disease 2019 (COVID-19) was first diagnosed in Scotland on 1 March 2020. During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital admissions, 207 intensive care admissions and 126 deaths. We aimed to identify the source and number of introductions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into Scotland using a combined phylogenetic and epidemiological approach. Sequencing of 1,314 SARS-CoV-2 viral genomes from available patient samples enabled us to estimate that SARS-CoV-2 was introduced to Scotland on at least 283 occasions during February and March 2020. Epidemiological analysis confirmed that early introductions of SARS-CoV-2 originated from mainland Europe (the majority from Italy and Spain). We identified subsequent early outbreaks in the community, within healthcare facilities and at an international conference. Community transmission occurred after 2 March, 3 weeks before control measures were introduced. Earlier travel restrictions or quarantine measures, both locally and internationally, would have reduced the number of COVID-19 cases in Scotland. The risk of multiple reintroduction events in future waves of infection remains high in the absence of population immunity.Entities:
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Year: 2020 PMID： 33349681 DOI： 10.1038/s41564-020-00838-z
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745