Literature DB >> 3334748

Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence.

P F Szurek1, P H Yuen, R Jerzy, P K Wong.   

Abstract

ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, induces hind-limb paralysis in mice. The DNA of both the ts1 and Moloney murine leukemia virus TB env genes has been sequenced, and the encoded amino acid sequences have been deduced from the DNA sequences. Four amino acids in the ts1 envelope protein have been identified which may be responsible for the ts1 phenotype, which includes temperature sensitivity, nonprocessing of Pr80env, and neurovirulence.

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Year:  1988        PMID： 3334748      PMCID： PMC250539     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I. Origin and introductory investigations.

Authors:  J B MOLONEY
Journal:  J Natl Cancer Inst       Date:  1960-04       Impact factor: 13.506

2.  Rapid, selective procedure for isolation of spontaneous temperature-sensitive mutants of Moloney leukemia virus.

Authors:  P K Wong; L J Russ; J A McCarter
Journal:  Virology       Date:  1973-02       Impact factor: 3.616

3.  Nucleotide sequence of Moloney murine leukaemia virus.

Authors:  T M Shinnick; R A Lerner; J G Sutcliffe
Journal:  Nature       Date:  1981 Oct 15-21       Impact factor: 49.962

4.  Topography of murine leukemia virus envelope proteins: characterization of transmembrane components.

Authors:  A Pinter; W J Honnen
Journal:  J Virol       Date:  1983-06       Impact factor: 5.103

5.  Nucleotide sequence of the envelope gene of Friend murine leukemia virus.

Authors:  W Koch; G Hunsmann; R Friedrich
Journal:  J Virol       Date:  1983-01       Impact factor: 5.103

6.  Nucleotide sequence of the Akv env gene.

Authors:  J Lenz; R Crowther; A Straceski; W Haseltine
Journal:  J Virol       Date:  1982-05       Impact factor: 5.103

7.  A fast replica plating technique for the isolation of post-integration mutants of the Moloney strain of murine leukaemia virus.

Authors:  R Rude; G E Gallick; P K Wong
Journal:  J Gen Virol       Date:  1980-08       Impact factor: 3.891

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  A group of temperature-sensitive mutants of Moloney leukemia virus which is defective in cleavage of env precursor polypeptide in infected cells also induces hind-limb paralysis in newborn CFW/D mice.

Authors:  P K Wong; M M Soong; R MacLeod; G E Gallick; P H Yuen
Journal:  Virology       Date:  1983-03       Impact factor: 3.616

10.  Deformed whiskers in mice infected with certain exogenous murine leukemia viruses.

Authors:  W P Rowe
Journal:  Science       Date:  1983-08-05       Impact factor: 47.728
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  35 in total

1.  Site-directed mutagenesis of the codon for Ile-25 in gPr80env alters the neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.

Authors:  P F Szurek; E Floyd; P H Yuen; P K Wong
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

2.  An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor.

Authors:  J M Heard; O Danos
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

3.  Sequence variability of bovine leukemia virus env gene and its relevance to the structure and antigenicity of the glycoproteins.

Authors:  R Z Mamoun; M Morisson; N Rebeyrotte; B Busetta; D Couez; R Kettmann; M Hospital; B Guillemain
Journal:  J Virol       Date:  1990-09       Impact factor: 5.103

4.  Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain.

Authors:  Karin E Peterson; Susan Pourciau; Min Du; Rachel Lacasse; Melissa Pathmajeyan; David Poulsen; Mavis Agbandje-McKenna; Kathy Wehrly; Bruce Chesebro
Journal:  J Virol       Date:  2008-06-25       Impact factor: 5.103

5.  Potential retroviral RNAs in Creutzfeldt-Jakob disease.

Authors:  G H Murdoch; T Sklaviadis; E E Manuelidis; L Manuelidis
Journal:  J Virol       Date:  1990-04       Impact factor: 5.103

6.  SV7, a molecular clone of Moloney murine sarcoma virus 349, transforms vascular endothelial cells.

Authors:  P H Yuen; C M Matherne; L M Molinari-Storey
Journal:  Am J Pathol       Date:  1991-12       Impact factor: 4.307

7.  Identification of a sequence in the unique 5' open reading frame of the gene encoding glycosylated Gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus.

Authors:  J L Portis; G J Spangrude; F J McAtee
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

8.  Studies on the pathology, especially brain lesions, induced by R7, a spontaneous mutant of Moloney murine sarcoma virus 124.

Authors:  P H Yuen; Y T Kwak
Journal:  Am J Pathol       Date:  1998-06       Impact factor: 4.307

9.  ts1-Induced spongiform encephalomyelopathy: physical forms of high-mobility DNA in spinal cord tissues of paralyzed mice are products of premature termination of reverse transcription.

Authors:  P F Szurek; B R Brooks
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

10.  A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.

Authors:  P F Szurek; P H Yuen; J K Ball; P K Wong
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103
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