Magnetic resonance imaging analysis of rotator cuff tear after shoulder dislocation in a patient older than 40 years.

BACKGROUND: This study was designed to evaluate characters of the rotator cuff tear (RCT) recognized after primary shoulder dislocation in patients older than 40.
METHODS: From 2008 to 2019, patients who visited two hospitals after dislocation were retrospectively reviewed. Inclusion criteria were patients over 40 who had dislocation, with magnetic resonance imaging (MRI) undergone. Exclusion criteria were patients who lost to follow-up, combined with any proximal humerus fracture, brachial plexus injury, and previous operation or dislocation history in the ipsilateral shoulder. Also patients who had only bankart or bony bakart lesion in MRI were excluded. We evaluated RCTs that were recognized by MRI after the primary shoulder dislocation with regard to tear size, degree, involved tendons, fatty degeneration, the age when the first dislocation occurred, and the duration until the MRI was evaluated after the dislocation.
RESULTS: Fifty-five RCTs were included. According to age groups, the tear size was increased in coronal and sagittal direction, the number of involved tendons was increased, and the degree of fatty degeneration was advanced in infraspinatus muscle. Thirty-two cases (58.2%) conducted MRI after 3 weeks from the first shoulder dislocation event. This group showed that the retraction size of the coronal plane was increased significantly and the fatty accumulation of the supraspinatus muscle had progressed significantly.
CONCLUSIONS: Age is also a strong factor to affect the feature of RCT after the shoulder dislocation in patients over 40. And the delay of the MRI may deteriorate the degree of tear size and fatty degeneration.

INTRODUCTION

The prevalence of traumatic anterior shoulder dislocation in the elderly has increased due to recent changes in lifestyle and life expectancy [1]. Recurrent instability is the main problem after shoulder dislocation in young patients, while rotator cuff tear is more common in the elderly [2,3]. However, immediate diagnosis of pathology is very difficult because most patients visit and present via the emergency room and may not undergo further evaluation. Revisiting the clinic after reduction is relatively uncommon especially for elderly patients, and it is currently debated whether magnetic resonance imaging (MRI) should be performed within in a short time period after the first dislocation [2,4-6].

It is unclear whether shoulder dislocation triggers rotator cuff tear or whether an asymptomatic, pre-existing rotator cuff tear induces imbalanced shoulder movement, resulting in shoulder dislocation with minor trauma [7,8]. In older patients, it is difficult to distinguish the acute and chronic features of rotator cuff tear that are recognized after primary shoulder dislocation. It is also uncertain whether delay of the diagnosis contributes to adverse outcomes and prognosis [4,5,9,10]. MRI is regarded as the most accurate diagnostic modality to detect rotator cuff tear and for estimating tear degree and tissue quality [6,11,12].

About 60% of nontraumatic rotator cuff tears remain asymptomatic for years [13-15], while most cases develop the first symptoms after significant trauma. One study reported significantly higher prevalence of rotator cuff tear after trauma compared to a control group without trauma [16]. Thus, it must be determined whether shoulder dislocation truly causes rotator cuff tear or if patients with an asymptomatic rotator cuff tear are exacerbated by a single dislocation event [9,17]. Although some studies suggest a number of symptoms to distinguish between solely traumatic and purely degenerative rotator cuff tear, such as patient medical history, physical examination, and imaging modalities [18,19], these factors are insufficient for complete differentiation and lack evidence-based data. This study was designed to evaluate characteristics of rotator cuff tear using MRI to recognize incidents after primary shoulder dislocation in patients older than 40 years.

METHODS

Seventy-four patients older than 40 years who presented for treatment of traumatic anterior dislocation of the shoulder from 2008 to 2019 were retrospectively reviewed. Of these patients, three were lost to follow-up. Eight patients with proximal humerus fracture, brachial plexus injury, previous shoulder operation, or dislocation history in the ipsilateral shoulder were excluded. Another eight patients were excluded because they had only Bankart or bony Bankart lesion on MRI. Therefore, a total of 55 patients was enrolled in this study.

Demographic data were obtained through chart review. All rotator cuff tears were confirmed by MRI after the dislocation event. MRI was performed at two imaging centers using a 1.5- or 3.0-T imaging unit (Sigma; GE Medical Systems, Milwaukee, WI, USA) equipped with a dedicated shoulder coil. A standardized imaging protocol was used according to hospital parameters, but two of the protocols did not align. The following MRI sequences were included for review: fat-suppressed T1-weighted fast spin echo sequences in the axial and oblique coronal planes parallel to the long axis of the supraspinatus tendon and the oblique sagittal plane perpendicular to the long axis of the supraspinatus tendon. Images were acquired with a slice thickness of 3 mm and an interslice gap with a 1 mm field of view of 16×16 cm. Images were interpreted using a standard picture archiving and communication system (PACS) workstation (Centricity, GE Medical Systems). All MRI findings were interpreted by two board-certified orthopedic surgeons (JHK, YMN) who confirmed the degree of fatty infiltration and tear size. Two weeks later, the procedure was repeated for validation (Table 1).

Table 1.

Overall patient data

Variable	Value
Number	55
Age (yr)	61.2±11.5 (40–82)
Sex (male:female)	34:21
Follow-up period (mo)	48.7±36.6 (12–115)
Duration (wk)	17.1±21.4 (1–96)
Fatty degeneration grade
Supraspinatus muscle	1.71±1.12
Infraspinatus muscle	1.33±1.11
Subscapularis muscle	1.04±0.83
Teres minor muscle	0.20±0.48

Values are presented as mean±standard deviation (range) or mean±standard deviation.

A tear was defined as a discontinuity of tendon fibers with the gap showing a high T2 signal [20-22]. A full-thickness tear was defined as a high signal extending through the depth of the tendon. The tear was measured in two planes (anterior to posterior [AP] and medial to lateral [ML]) on the full-thickness supraspinatus or infraspinatus muscle.

Fatty infiltration was graded on a scale from 0 to 4 as a modification of the classification of Goutallier et al. [23]. It was adapted to MRI: grade 0 means no fatty deposits; grade 1, some fatty streaks; grade 2, more muscle than fat; grade 3, fat equal to muscle; and grade 4, more fat than muscle.

To evaluate the effect of delayed MRI after the first injury event, we divided patients into two groups based on time from injury to MRI evaluation. The first group (group I) waited less than 3 weeks after dislocation, while group II was evaluated more than 3 weeks after dislocation. Three weeks was used as the cutoff based on previous clinical reports [4,24].

Comparative statistics were performed using Student t-test, chi-square test, or Fisher’s exact test (IBM SPSS ver. 19; IBM Corp., Armonk, NY, USA). The level of significance was set at P<0.05. Data are presented as mean±standard deviation.

RESULTS

Fifty-five rotator cuff tears were recognized on MRI after the first anterior dislocation of the shoulder. The average follow-up period was 48.7±38.6 months (range, 12–115 months). The age of the patients at the time of primary shoulder dislocation was 61.2±11.5 years (range, 40–82 years). There were 21 women with a mean age of 64.5±10.2 years and 34 men with a mean age of 59.2±10.9 years. The mean duration between primary shoulder dislocation and MRI evaluation was 17.1±21.4 weeks (range, 1–96 weeks). The mean degree of fatty degeneration was 1.71 in the supraspinatus muscle, 1.33 in the infraspinatus muscle, 1.04 in the subscapularis muscle, and 0.20 in the teres minor muscle (Table 1).

Of the 55 shoulders, 26 (47.3%) had isolated rotator cuff tear (R group) and 29 (52.7%) had combined Bankart lesion with rotator cuff tear (B+R group). The mean age was 69.12±8.84 years in the R group and 61.14±10.52 years in the B+R group, a significant difference. The mean tear size in the sagittal and coronal planes in the R group was 31.12±8.57 mm and 30.81±8.60 mm, respectively. The R group had significantly longer tear size in both directions compared with the B+R group (16.61 ±12.80 mm and 16.93±12.32 mm, respectively). The number of cases in the R group with more than two injured tendons was 26 (100%) and the number of cases that involved a long head of the biceps tendon lesion was 22 (84.6%). The degree of fatty degeneration of the rotator cuff was significantly different between the two groups, with exception of the teres minor muscle (Fig. 1). These findings are summarized in (Table 2).

Fig. 1.

Distribution of degree of fatty degeneration of the supraspinatus muscle (A), infraspinatus muscle (B), and subscapularis muscle (C) between the B+R and R groups. The results indicate significant differences for these muscles. B+R group: rotator cuff tear combined with labral tear group, R group: rotator cuff tear group, Grade (Gr)0: no fatty deposits, Gr1: some fatty streaks, Gr2: more muscle than fat, Gr3: fat equal to muscle.

Table 2.

Comparison of age, tear size, number of injured tendons, and accompanying injuries between two groups

Variable	B+R group	R group	P-value
Number	29 (52.7)	26 (47.3)
Age (yr)	61.12±10.52	69.12±8.84	0.000
Tear size (mm)
AP	16.61±12.80	31.12±8.57	0.000
ML	16.93±12.32	30.81±8.60	0.000
No. of injured tendons			0.005
1 (SS)	8	0
≥ 2 (SS+IS)	21	26
Accompanying injury
LHBT lesion	15	22	0.011
Labral tear	25	0	0.000
Hill Sachs lesion	22	20	0.926

Values are presented as number (%) or mean±standard deviation. B+R group: rotator cuff tear combined with labral tear group , R group: rotator cuff tear group.

AP: anterior to posterior, ML: medial to lateral, SS: supraspinatus, IS: infraspinatus, LHBT: long head of the biceps tendon.

Age and tear size in both directions were positively correlated (Pearson’s correlation coefficient 0.476 in the AP direction and 0.452 in the ML direction) (Fig. 2). The older age group showed significant increase in tear size, number of injured tendons, and long head biceps tendon lesions (Table 3). Interestingly, degree of fatty degeneration is advanced with age only in the infraspinatus muscle (Fig. 3).

Fig. 2.

Distribution of tear size from anterior to posterior direction (A) and medial to posterior direction (B) as age increases. Both directions showed positive correlation.

Table 3.

Comparison of tear size, number of injured tendons, and accompanying injuries according to age group

Variable	40–49 yr	50–59 yr	60–69 yr	≥70 yr	P-value
Number	9 (16.4)	15 (27.3)	17 (30.9)	14 (25.4)
Tear size (mm)
AP	10.30±9.16	20.40±13.08	28.41±9.91	29.21±12.69	0.001
ML	10.78±10.28	21.93±13.15	28.06±8.18	27.79±13.29	0.003
No. of injured tendons					0.016
1	4	3	0	1
≥2	5	12	17	13
Accompanying injury
LHBT lesion	3	8	14	12	0.019
Labral tear	8	10	4	3	0.001
Hill Sachs lesion	8	12	10	12	0.215

Values are presented as number (%) or mean±standard deviation.

AP: aanterior to posterior, ML: medial to lateral, LHBT: long head of the biceps tendon.

Fig. 3.

Distribution of fatty degeneration grade in the supraspinatus muscle (A), infraspinatus muscle (B), and subscapularis muscle (C) according to age group. Degree of fatty degeneration showed a significant difference in the infraspinatus muscle. Grade (Gr)0: no fatty deposits, Gr1: some fatty streaks, Gr2: more muscle than fat, Gr3: fat equal to muscle.

When shoulders were divided into two groups by a 3-week duration between the first dislocation event and the MRI procedure, 23 (41.8%) were evaluated within 3 weeks after injury and 32 shoulders (58.2%) were evaluated after more than 3 weeks. There was no difference between the two groups in age, number of injured tendons, or associated lesions. However, retraction size of the coronal plane was increased and fatty accumulation of the supraspinatus muscle was more advanced in group I (less than 3 weeks) than group II (more than 3 weeks) (Table 4, Fig. 4).

Table 4.

Comparison of age, tear size, number of injured tendons, and accompanying injuries according to duration from injury to MRI

Variable	Duration (wk)		P-value
	0–3	≥ 3
Number	23 (41.8)	32 (58.2)
Age (yr)	62.87±11.61	60.03±10.65	0.352
Tear size (mm)
AP	20.52±13.79	25.58±12.42	0.160
ML	19.09±11.62	26.66±12.70	0.028
No. of injured tendons			0.120
1	1	7
≥2	22	25
Accompanying injury
LHBT lesion	14	23	0.391
Labral tear	12	13	0.396
Hill Sachs lesion	15	27	0.099

Values are presented as number (%) or mean±standard deviation. MRI: magnetic resonance imaging, AP: anterior to posterior, ML: medial to lateral, LHBT: long head of the biceps tendon.

Fig. 4.

Distribution of fatty degeneration grade in the supraspinatus muscle (A), infraspinatus muscle (B), and subscapularis muscle (C) according to duration from injury to magnetic resonance imaging. Degree of fatty degeneration showed a significant difference in the supraspinatus muscle. Grade (Gr)0: no fatty deposits, Gr1: some fatty streaks, Gr2: more muscle than fat, Gr3: fat equal to muscle.

DISCUSSION

In this study, we focused on rotator cuff tear recognized on MRI after a dislocation event. As age progresses, the rotator cuff weakens and is more prone to tearing [25,26]. The results of this study indicate that age is a strong factor of tear size, number of involved tendons, and fatty degeneration of the infraspinatus muscle in primary shoulder dislocation in patients older than 40 years. It is apparent that fatty degeneration and tear progression progress in the AP direction (from supraspinatus to infraspinatus) because the degree of fatty degeneration was significantly different in the infraspinatus muscle in the older age group. Because the infraspinatus muscle is the main depressor of the humeral head, dysfunction results in upward migration of the humerus with subacromial impingement and loss of strength in external rotation and elevation [27,28]. We assumed that it is paramount to recognize rapid fatty infiltration of the infraspinatus to avoid poor outcomes after cuff repair in patients older than 40 years, particularly for those with shoulder dislocation of fatty infiltration grade 2 or higher [29].

The rotator cuff significantly contributes to the stability of the glenohumeral joint, especially in elderly patients. It is possible that the higher prevalence of pre-existing rotator cuff disease in older patients may lead to abnormal glenohumeral motion and predispose an older individual to shoulder instability with low-energy trauma [7,30]. Hsu et al. [30] showed in a cadaver model that rotator cuff tear resulted in abnormal glenohumeral translation, and that larger tears had a greater tendency for direct anterior translation. Pouliart and Gagey [31] showed that the humeral head dislocates in the presence of less extensive capsuloligamentous lesions when rotator cuff lesions are present. Increased age, advanced fatty infiltration, and longer tear size might have weakened the posterior structures and resulted in anterior dislocation without anteroinferior labral lesion, such as Bankart lesion in the elderly. These characteristics are also shown in our results, which indicated that the rotator cuff tear group (R group) was statistically much older than the rotator cuff combined with labral tear group (B+R group). The R group cases all involved an infraspinatus tear, while infraspinatus tear involvement was present in about 72.4% of the BR group. These results suggest that shoulder dislocation without labral tear is strongly related with infraspinatus tear in elderly patients and is referred to as the posterior shoulder dislocation mechanism [7,30,31]. In our results, fatty degeneration of the subscapularis was not statistically different according to age or between the R and B+R groups.

Delayed diagnosis of rotator cuff tear after dislocation may decrease the recovery potential. Previous studies [4,24] reported that patients who experienced acute injury with severe compromise of shoulder function that could be due to the rotator cuff tear should be diagnosed using further evaluations, and that surgical repair of rotator cuff tear should be performed within 3 weeks of injury to achieve the best surgical results. Failure to meet the conservative 3-week treatment window after primary dislocation in older patients and persistence of significant pain or weakness are indications for further investigation [32,33]. Another study showed that infraspinatus fatty infiltration increased significantly when multiple tendons were torn, and that surgical repair should be performed before stage 2 fatty infiltration in older patients [34].

We hypothesized that rotator cuff tear identified by MRI after 3 weeks from dislocation may have features different from those of tear identified earlier. Based on our results, coronal tear size and degree of fatty infiltration in the supraspinatus muscle were increased significantly in the group with more than 3 weeks before intervention (Table 4, Fig. 4). These results suggest that shoulder dislocation may worsen the course of degeneration even in the early period of post-dislocation in elderly patients. These results also provide a theoretical background for understanding why rapid rotator cuff repair might be considered in acute shoulder dislocation due to the tendency of rapid fatty progression in elderly patients. Previous studies have reported inferior clinical results after delayed treatment of traumatic rotator cuff tear, which is likely due to loss of elasticity in tendons and the significantly increased tension of the repair. Increased tension is related to decreased viscoelastic properties of the tendons and poor rotator cuff healing [24,35]. In a rat model, supraspinatus tendon detachment resulted in rapid loss of muscle mass by 1 week after injury [36,37]. In biomechanical studies, tension at the repaired tendon progressively increased with time from injury because of increase in retraction of the musculotendinous unit and in stiffness of the muscle and tendon [38,39]. Unfortunately, we could not evaluate clinical outcomes according to duration and so assumed that delayed diagnosis and treatment may have adverse effects on clinical outcomes based on our results and previous studies.

This study had several limitations; in particular, the relatively small number of cases and their retrospective enrollment. This study could not distinguish between acute lesion and chronic lesion of the rotator cuff, and there were no clinical outcomes to evaluate function, satisfaction, or additional dislocation in patients because of difficulty with long-term follow-up. We also did not have a uniform MRI protocol because the MRI studies were conducted at different institutions and during different timeframes from 2008 to 2019. However, we do not believe that such differences compromised our ability to analyze fatty infiltration.

We concluded that tear size of the rotator cuff and fatty infiltration of the infraspinatus muscle are positively correlated with age in primary shoulder dislocation in patients older than 40 years. Combined Bankart lesion is more frequently observed in younger patients. Tear size (ML) of the rotator cuff and fatty infiltration of the supraspinatus may advance faster after dislocation in this age group, and careful attention, diagnosis, and follow-up are important for optimizing patient outcomes.