Girish B Nair1, Craig J Galban2, Sayf Al-Katib3, Robert Podolsky4, Maarten van den Berge5, Craig Stevens6, Edward Castillo6,7. 1. Division of Pulmonary and Critical Care, Beaumont Health, OUWB School of Medicine, Auburn Hills, MI, USA. 2. Department of Radiology, University of Michigan, Ann Arbor, MI, USA. 3. Department of Radiology and Molecular Imaging, Beaumont Health, OUWB School of Medicine, Auburn Hills, MI, USA. 4. Division of Informatics & Biostatistics, Beaumont Research Institute, Beaumont Health, Beaumont, TX, USA. 5. Department of Pulmonary Disease, University Medical Center Groningen, Groningen, The Netherlands. 6. Department of Radiation Oncology, Beaumont Health, OUWB School of Medicine, Auburn Hills, MI, USA. 7. Department of Computational and Applied Mathematics, Rice University, Houston, TX, USA.
Abstract
OBJECTIVE: To evaluate CT-ventilation imaging (CTVI) within a well-characterized, healthy cohort with no respiratory symptoms and examine the correlation between CTVI and concurrent pulmonary function test (PFT). METHODS: CT scans and PFTs from 77 Caucasian participants in the NORM dataset (clinicaltrials.gov NCT00848406) were analyzed. CTVI was generated using the robust Integrated Jacobian Formulation (IJF) method. IJF estimated total lung capacity (TLC) was computed from CTVI. Bias-adjusted Pearson's correlation between PFT and IJF-based TLC was computed. RESULTS: IJF- and PFT-measured TLC showed a good correlation for both males and females [males: 0.657, 95% CI (0.438-0.797); females: 0.667, 95% CI (0.416-0.817)]. When adjusting for age, height, smoking, and abnormal CT scan, correlation moderated [males: 0.432, 95% CI (0.129-0.655); females: 0.540, 95% CI (0.207-0.753)]. Visual inspection of CTVI revealed participants who had functional defects, despite the fact that all participant had normal high-resolution CT scan. CONCLUSION: In this study, we demonstrate that IJF computed CTVI has good correlation with concurrent PFT in a well-validated patient cohort with no respiratory symptoms. ADVANCES IN KNOWLEDGE: IJF-computed CTVI's overall numerical robustness and consistency with PFT support its potential as a method for providing spatiotemporal assessment of high and low function areas on volumetric non-contrast CT scan.
OBJECTIVE: To evaluate CT-ventilation imaging (CTVI) within a well-characterized, healthy cohort with no respiratory symptoms and examine the correlation between CTVI and concurrent pulmonary function test (PFT). METHODS: CT scans and PFTs from 77 Caucasian participants in the NORM dataset (clinicaltrials.gov NCT00848406) were analyzed. CTVI was generated using the robust Integrated Jacobian Formulation (IJF) method. IJF estimated total lung capacity (TLC) was computed from CTVI. Bias-adjusted Pearson's correlation between PFT and IJF-based TLC was computed. RESULTS: IJF- and PFT-measured TLC showed a good correlation for both males and females [males: 0.657, 95% CI (0.438-0.797); females: 0.667, 95% CI (0.416-0.817)]. When adjusting for age, height, smoking, and abnormal CT scan, correlation moderated [males: 0.432, 95% CI (0.129-0.655); females: 0.540, 95% CI (0.207-0.753)]. Visual inspection of CTVI revealed participants who had functional defects, despite the fact that all participant had normal high-resolution CT scan. CONCLUSION: In this study, we demonstrate that IJF computed CTVI has good correlation with concurrent PFT in a well-validated patient cohort with no respiratory symptoms. ADVANCES IN KNOWLEDGE: IJF-computed CTVI's overall numerical robustness and consistency with PFT support its potential as a method for providing spatiotemporal assessment of high and low function areas on volumetric non-contrast CT scan.
Authors: Sang Min Lee; Joon Beom Seo; Sang Young Oh; Tae Hoon Kim; Jin Woo Song; Sang Min Lee; Namkug Kim Journal: Eur Radiol Date: 2017-09-19 Impact factor: 5.315
Authors: Tokihiro Yamamoto; Sven Kabus; Jens von Berg; Cristian Lorenz; Melody P Chung; Julian C Hong; Billy W Loo; Paul J Keall Journal: Acad Radiol Date: 2012-09-10 Impact factor: 3.173
Authors: Tokihiro Yamamoto; Sven Kabus; Tobias Klinder; Jens von Berg; Cristian Lorenz; Billy W Loo; Paul J Keall Journal: Med Phys Date: 2011-03 Impact factor: 4.071
Authors: Yevgeniy Vinogradskiy; Chad G Rusthoven; Leah Schubert; Bernard Jones; Austin Faught; Richard Castillo; Edward Castillo; Laurie E Gaspar; Jennifer Kwak; Timothy Waxweiler; Michele Dougherty; Dexiang Gao; Craig Stevens; Moyed Miften; Brian Kavanagh; Thomas Guerrero; Inga Grills Journal: Int J Radiat Oncol Biol Phys Date: 2018-10-18 Impact factor: 7.038
Authors: Agnes Luzak; Elaine Fuertes; Claudia Flexeder; Marie Standl; Andrea von Berg; Dietrich Berdel; Sibylle Koletzko; Joachim Heinrich; Dennis Nowak; Holger Schulz Journal: Respir Res Date: 2017-07-12
Authors: Edward Castillo; Richard Castillo; Yevgeniy Vinogradskiy; Michele Dougherty; David Solis; Nicholas Myziuk; Andrew Thompson; Rudy Guerra; Girish Nair; Thomas Guerrero Journal: Med Phys Date: 2019-03-22 Impact factor: 4.071
Authors: Edward Castillo; Richard Castillo; Yevgeniy Vinogradskiy; Girish Nair; Inga Grills; Thomas Guerrero; Craig Stevens Journal: Med Phys Date: 2020-10-17 Impact factor: 4.071