| Literature DB >> 33303686 |
Jacob E Lemieux1,2, Katherine J Siddle3,4, Glen R Gallagher5, Lawrence C Madoff5,6, Sandra Smole5, Virginia M Pierce7,8,9, Eric Rosenberg2,7, Pardis C Sabeti1,4,10,11,12, Daniel J Park3, Bronwyn L MacInnis1,10,11, Bennett M Shaw3,2, Christine Loreth3, Stephen F Schaffner3,4,10, Adrianne Gladden-Young3, Gordon Adams3, Timelia Fink5, Christopher H Tomkins-Tinch3,4, Lydia A Krasilnikova3,4, Katherine C DeRuff3, Melissa Rudy3, Matthew R Bauer3,13, Kim A Lagerborg3,13, Erica Normandin3,14, Sinéad B Chapman3, Steven K Reilly3,4, Melis N Anahtar7, Aaron E Lin3,4, Amber Carter3, Cameron Myhrvold3,4, Molly E Kemball3,14, Sushma Chaluvadi3, Caroline Cusick3, Katelyn Flowers3, Anna Neumann3, Felecia Cerrato3, Maha Farhat15,16, Damien Slater2, Jason B Harris2,17, John A Branda7, David Hooper2, Jessie M Gaeta18,19, Travis P Baggett18,20,21, James O'Connell18,20,21, Andreas Gnirke3, Tami D Lieberman3,22, Anthony Philippakis3, Meagan Burns5, Catherine M Brown5, Jeremy Luban3,23,11, Edward T Ryan2,10,21, Sarah E Turbett2,7,21, Regina C LaRocque2,21, William P Hanage24.
Abstract
Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed substantially in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help to understand the link between individual clusters and wider community spread.Entities:
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Year: 2020 PMID： 33303686 PMCID： PMC7857412 DOI： 10.1126/science.abe3261
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728