Bastien Reyné1, Christian Selinger1, Mircea T Sofonea1, Stéphanie Miot2, Amandine Pisoni3, Edouard Tuaillon3, Jean Bousquet4,5,6, Hubert Blain2, Samuel Alizon1. 1. Maladies Infectieuses et Vecteurs: Écologie Génétique Évolution Contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD), Université de Montpellier, France. 2. Department of Geriatrics, Montpellier University Hospital, Montpellier University, France. 3. Pathogenesis & Control of Chronic Infections, Institut National de la Santé et de la Recherche Médicale (INSERM), U1058, Établissement Français du Sang (EFS), Montpellier University and Laboratory of Virology, Centre Hospitalier Universitaire de Montpellier, France. 4. Charité, Universitätsmedizin Berlin, Humboldt-Universität Berlin, Berlin, Germany. 5. Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Berlin, Germany. 6. Combattre les Maladies Chroniques Pour un Vieillissement Actif (MACVIA)-France, Montpellier, France.
Abstract
BACKGROUND: The COVID-19 epidemic has spread rapidly within aged-care facilities (ACFs), where the infection-fatality ratio is high. It is therefore urgent to evaluate the efficiency of infection prevention and control (IPC) measures in reducing SARS-CoV-2 transmission. METHODS: We analysed the COVID-19 outbreaks that took place between March and May 2020 in 12 ACFs using reverse transcription-polymerase chain reaction (RT-PCR) and serological tests for SARS-CoV-2 infection. Using maximum-likelihood approaches and generalized linear mixed models, we analysed the proportion of infected residents in ACFs and identified covariates associated with the proportion of infected residents. RESULTS: The secondary-attack risk was estimated at 4.1%, suggesting a high efficiency of the IPC measures implemented in the region. Mask wearing and the establishment of COVID-19 zones for infected residents were the two main covariates associated with lower secondary-attack risks. CONCLUSIONS: Wearing masks and isolating potentially infected residents appear to be associated with a more limited spread of SARS-CoV-2 in ACFs.
BACKGROUND: The COVID-19 epidemic has spread rapidly within aged-care facilities (ACFs), where the infection-fatality ratio is high. It is therefore urgent to evaluate the efficiency of infection prevention and control (IPC) measures in reducing SARS-CoV-2 transmission. METHODS: We analysed the COVID-19 outbreaks that took place between March and May 2020 in 12 ACFs using reverse transcription-polymerase chain reaction (RT-PCR) and serological tests for SARS-CoV-2 infection. Using maximum-likelihood approaches and generalized linear mixed models, we analysed the proportion of infected residents in ACFs and identified covariates associated with the proportion of infected residents. RESULTS: The secondary-attack risk was estimated at 4.1%, suggesting a high efficiency of the IPC measures implemented in the region. Mask wearing and the establishment of COVID-19 zones for infected residents were the two main covariates associated with lower secondary-attack risks. CONCLUSIONS: Wearing masks and isolating potentially infected residents appear to be associated with a more limited spread of SARS-CoV-2 in ACFs.
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