| Literature DB >> 33293939 |
Yongxi Zhao1, Xiaolei Zuo2, Qian Li3, Feng Chen1, Yan-Ru Chen4, Jinqi Deng5, Da Han2, Changlong Hao6, Fujian Huang7, Yanyi Huang8, Guoliang Ke9, Hua Kuang6, Fan Li2, Jiang Li10,11, Min Li2, Na Li12, Zhenyu Lin13, Dingbin Liu14, Juewen Liu15, Libing Liu16,17, Xiaoguo Liu3, Chunhua Lu13, Fang Luo13, Xiuhai Mao2, Jiashu Sun5, Bo Tang12, Fei Wang3, Jianbin Wang18, Lihua Wang10,11, Shu Wang15, Lingling Wu2, Zai-Sheng Wu4, Fan Xia7, Chuanlai Xu6, Yang Yang2, Bi-Feng Yuan19, Quan Yuan9, Chao Zhang2, Zhi Zhu20, Chaoyong Yang2,20, Xiao-Bing Zhang9, Huanghao Yang13, Weihong Tan2,9, Chunhai Fan2,3.
Abstract
Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic analysis. During the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological breakthroughs. In this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided. © Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020.Entities:
Keywords: DNA nanotechnology; aptamer; biosensing; nucleic acids analysis; signal amplification
Year: 2020 PMID： 33293939 PMCID： PMC7716629 DOI： 10.1007/s11426-020-9864-7
Source DB: PubMed Journal: Sci China Chem ISSN： 1869-1870 Impact factor: 9.445