| Literature DB >> 33242417 |
Willian A da Silveira1, Hossein Fazelinia2, Sara Brin Rosenthal3, Evagelia C Laiakis4, Man S Kim2, Cem Meydan5, Yared Kidane6, Komal S Rathi2, Scott M Smith7, Benjamin Stear2, Yue Ying2, Yuanchao Zhang2, Jonathan Foox5, Susana Zanello8, Brian Crucian7, Dong Wang9, Adrienne Nugent10, Helio A Costa11, Sara R Zwart12, Sonja Schrepfer9, R A Leo Elworth13, Nicolae Sapoval13, Todd Treangen13, Matthew MacKay5, Nandan S Gokhale14, Stacy M Horner14, Larry N Singh15, Douglas C Wallace16, Jeffrey S Willey17, Jonathan C Schisler18, Robert Meller19, J Tyson McDonald4, Kathleen M Fisch3, Gary Hardiman20, Deanne Taylor21, Christopher E Mason5, Sylvain V Costes22, Afshin Beheshti23.
Abstract
Spaceflight is known to impose changes on human physiology with unknown molecular etiologies. To reveal these causes, we used a multi-omics, systems biology analytical approach using biomedical profiles from fifty-nine astronauts and data from NASA's GeneLab derived from hundreds of samples flown in space to determine transcriptomic, proteomic, metabolomic, and epigenetic responses to spaceflight. Overall pathway analyses on the multi-omics datasets showed significant enrichment for mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circadian rhythm, and olfactory functions. Importantly, NASA's Twin Study provided a platform to confirm several of our principal findings. Evidence of altered mitochondrial function and DNA damage was also found in the urine and blood metabolic data compiled from the astronaut cohort and NASA Twin Study data, indicating mitochondrial stress as a consistent phenotype of spaceflight.Entities:
Keywords: GeneLab; NASA; NASA Twin Study; Rodent Research Missions; lipids; microgravity; mitochondria; space radiation; spaceflight; transcriptomic
Mesh：
Year: 2020 PMID： 33242417 PMCID： PMC7870178 DOI： 10.1016/j.cell.2020.11.002
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582