| Literature DB >> 33242416 |
Ebrahim Afshinnekoo1, Ryan T Scott2, Matthew J MacKay1, Eloise Pariset3, Egle Cekanaviciute4, Richard Barker5, Simon Gilroy5, Duane Hassane6, Scott M Smith7, Sara R Zwart8, Mayra Nelman-Gonzalez9, Brian E Crucian7, Sergey A Ponomarev10, Oleg I Orlov10, Dai Shiba11, Masafumi Muratani12, Masayuki Yamamoto13, Stephanie E Richards14, Parag A Vaishampayan4, Cem Meydan1, Jonathan Foox1, Jacqueline Myrrhe15, Eric Istasse15, Nitin Singh16, Kasthuri Venkateswaran16, Jessica A Keune17, Hami E Ray18, Mathias Basner19, Jack Miller20, Martha Hotz Vitaterna21, Deanne M Taylor22, Douglas Wallace23, Kathleen Rubins24, Susan M Bailey25, Peter Grabham26, Sylvain V Costes27, Christopher E Mason28, Afshin Beheshti29.
Abstract
Research on astronaut health and model organisms have revealed six features of spaceflight biology that guide our current understanding of fundamental molecular changes that occur during space travel. The features include oxidative stress, DNA damage, mitochondrial dysregulation, epigenetic changes (including gene regulation), telomere length alterations, and microbiome shifts. Here we review the known hazards of human spaceflight, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration. We also discuss the essential issues related to the health and safety of astronauts involved in future missions, especially planned long-duration and Martian missions.Entities:
Keywords: DNA damage; aerospace medicine; epigenetic; microbiome; mitochondria; multi-omics; oxidative stress; space biology; spaceflight; telomere
Mesh：
Year: 2020 PMID： 33242416 PMCID： PMC8441988 DOI： 10.1016/j.cell.2020.10.050
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 66.850