Janne Hamann1, Lisa Herzog1,2,3, Carina Wehrli1,4, Tomas Dobrocky5, Andrea Bink4, Marco Piccirelli4, Leonidas Panos6, Johannes Kaesmacher5,7, Urs Fischer6, Christoph Stippich4, Andreas R Luft1, Jan Gralla5, Marcel Arnold6, Roland Wiest5, Beate Sick2,3, Susanne Wegener1. 1. Department of Neurology and Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland. 2. Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland. 3. Institute of Data Analysis and Process Design, ZHAW Winterthur, Winterthur, Switzerland. 4. Department of Neuroradiology and Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland. 5. Diagnostic and Interventional Neuroradiology, University Hospital of Berne, Berne, Switzerland. 6. Department of Neurology, University Hospital of Berne, Berne, Switzerland. 7. Department of Diagnostic, Interventional and Pediatric Radiology, University Hospital of Berne, Berne, Switzerland.
Abstract
BACKGROUND AND PURPOSE: Clinical outcomes vary substantially among individuals with large vessel occlusion (LVO) stroke. A small infarct core and large imaging mismatch were found to be associated with good recovery. The aim of this study was to investigate whether those imaging variables would improve individual prediction of functional outcome after early (<6 h) endovascular treatment (EVT) in LVO stroke. METHODS: We included 222 patients with acute ischemic stroke due to middle cerebral artery (MCA)-M1 occlusion who received EVT. As predictors, we used clinical variables and region of interest (ROI)-based magnetic resonance imaging features. We developed different machine-learning models and quantified their prediction performance according to the area under the receiver-operating characteristic curves and the Brier score. RESULTS: The rate of successful recanalization was 78%, with 54% patients having a favorable outcome (modified Rankin scale score 0-2). Small infarct core was associated with favorable functional outcome. Outcome prediction improved only slightly when imaging was added to patient variables. Age was the driving factor, with a sharp decrease in likelihood of favorable functional outcome above the age of 78 years. CONCLUSIONS: In patients with MCA-M1 occlusion strokes referred to EVT within 6 h of symptom onset, infarct core volume was associated with outcome. However, ROI-based imaging variables led to no significant improvement in outcome prediction at an individual patient level when added to a set of clinical predictors. Our study is in concordance with current practice, where imaging mismatch or collateral readouts are not recommended as factors for excluding patients with MCA-M1 occlusion for early EVT.
BACKGROUND AND PURPOSE: Clinical outcomes vary substantially among individuals with large vessel occlusion (LVO) stroke. A small infarct core and large imaging mismatch were found to be associated with good recovery. The aim of this study was to investigate whether those imaging variables would improve individual prediction of functional outcome after early (<6 h) endovascular treatment (EVT) in LVO stroke. METHODS: We included 222 patients with acute ischemic stroke due to middle cerebral artery (MCA)-M1 occlusion who received EVT. As predictors, we used clinical variables and region of interest (ROI)-based magnetic resonance imaging features. We developed different machine-learning models and quantified their prediction performance according to the area under the receiver-operating characteristic curves and the Brier score. RESULTS: The rate of successful recanalization was 78%, with 54% patients having a favorable outcome (modified Rankin scale score 0-2). Small infarct core was associated with favorable functional outcome. Outcome prediction improved only slightly when imaging was added to patient variables. Age was the driving factor, with a sharp decrease in likelihood of favorable functional outcome above the age of 78 years. CONCLUSIONS: In patients with MCA-M1 occlusion strokes referred to EVT within 6 h of symptom onset, infarct core volume was associated with outcome. However, ROI-based imaging variables led to no significant improvement in outcome prediction at an individual patient level when added to a set of clinical predictors. Our study is in concordance with current practice, where imaging mismatch or collateral readouts are not recommended as factors for excluding patients with MCA-M1 occlusion for early EVT.
Authors: Nathan A Shlobin; Ammad A Baig; Muhammad Waqas; Tatsat R Patel; Rimal H Dossani; Megan Wilson; Justin M Cappuzzo; Adnan H Siddiqui; Vincent M Tutino; Elad I Levy Journal: World Neurosurg Date: 2021-12-08 Impact factor: 2.210
Authors: Matthias A Mutke; Vince I Madai; Adam Hilbert; Esra Zihni; Arne Potreck; Charlotte S Weyland; Markus A Möhlenbruch; Sabine Heiland; Peter A Ringleb; Simon Nagel; Martin Bendszus; Dietmar Frey Journal: Front Neurol Date: 2022-05-27 Impact factor: 4.086