Alexandra E Dereix1, Rachel Ledyard2, Allyson M Redhunt3, Tessa R Bloomquist4, Kasey Jm Brennan4, Andrea A Baccarelli4, Michele R Hacker3,5,6, Heather H Burris2,7,8. 1. Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA. 2. Division of Neonatology, Children's Hospital of Pennsylvania, Philadelphia, PA 19104, USA. 3. Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. 4. Department of Environmental Health Sciences, Columbia University Mailman School of Public Health Environmental Health Sciences, New York, NY 10032, USA. 5. Department of Obstetrics, Gynecology & Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA. 6. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA. 7. Division of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. 8. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Abstract
Aim: To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor (NR3C1). Materials & methods: Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. NR3C1 methylation was determined at four methylation sites. Results: DNA methylation of CpG1 in the NR3C1 CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49-4.58) and trait anxiety (β 1.68, 95% CI: 0.14-3.22). No significant association was found between depressive symptoms and NR3C1 methylation. Conclusion: We found that maternal anxiety was associated with increased NR3C1 CpG island shore methylation.
Aim: To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor (NR3C1). Materials & methods: Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. NR3C1 methylation was determined at four methylation sites. Results: DNA methylation of CpG1 in the NR3C1 CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49-4.58) and trait anxiety (β 1.68, 95% CI: 0.14-3.22). No significant association was found between depressive symptoms and NR3C1 methylation. Conclusion: We found that maternal anxiety was associated with increased NR3C1 CpG island shore methylation.
Authors: Allen S Yang; Marcos R H Estécio; Ketan Doshi; Yutaka Kondo; Eloiza H Tajara; Jean-Pierre J Issa Journal: Nucleic Acids Res Date: 2004-02-18 Impact factor: 16.971
Authors: Shaowei Wu; Chris Gennings; Rosalind J Wright; Ander Wilson; Heather H Burris; Allan C Just; Joseph M Braun; Katherine Svensson; Jia Zhong; Kasey J M Brennan; Alexandra Dereix; Alejandra Cantoral; Lourdes Schnaas; Martha Maria Téllez-Rojo; Robert O Wright; Andrea A Baccarelli Journal: Psychosom Med Date: 2018-01 Impact factor: 4.312
Authors: Alexandra E Shields; Lauren A Wise; Edward A Ruiz-Narvaez; Bobak Seddighzadeh; Hyang-Min Byun; Yvette C Cozier; Lynn Rosenberg; Julie R Palmer; Andrea A Baccarelli Journal: Epigenomics Date: 2016-09-13 Impact factor: 4.778
Authors: Michael S Kramer; John Lydon; Louise Séguin; Lise Goulet; Susan R Kahn; Helen McNamara; Jacques Genest; Clément Dassa; Moy Fong Chen; Shakti Sharma; Michael J Meaney; Steven Thomson; Stan Van Uum; Gideon Koren; Mourad Dahhou; Julie Lamoureux; Robert W Platt Journal: Am J Epidemiol Date: 2009-04-10 Impact factor: 4.897
Authors: Valeska Stonawski; Stefan Frey; Yulia Golub; Nicolas Rohleder; Jennifer Kriebel; Tamme W Goecke; Peter A Fasching; Matthias W Beckmann; Johannes Kornhuber; Oliver Kratz; Gunther H Moll; Hartmut Heinrich; Anna Eichler Journal: Dev Psychopathol Date: 2018-04-02
Authors: Molly L Kile; Andrea Baccarelli; Elaine Hoffman; Letizia Tarantini; Quazi Quamruzzaman; Mahmuder Rahman; Golam Mahiuddin; Golam Mostofa; Yu-Mei Hsueh; Robert O Wright; David C Christiani Journal: Environ Health Perspect Date: 2012-03-30 Impact factor: 9.031
Authors: Liqing Wei; Xiaohong Ying; Mengxi Zhai; Jiayu Li; Dan Liu; Xin Liu; Bin Yu; Hong Yan Journal: Front Immunol Date: 2022-08-25 Impact factor: 8.786