Alexandra E Shields1,2, Lauren A Wise3,4, Edward A Ruiz-Narvaez3,4, Bobak Seddighzadeh2, Hyang-Min Byun5, Yvette C Cozier3,4, Lynn Rosenberg3,4, Julie R Palmer3,4, Andrea A Baccarelli2,6. 1. Harvard Medical School, 25 Shattuck St, Boston, MA 02114, USA. 2. Harvard/MGH Center on Genomics, Vulnerable Populations & Health Disparities, Massachusetts General Hospital, 50 Staniford St, Suite 901, Boston, MA 02114, USA. 3. Boston University School of Public Health, Talbot Building, 715 Albany St, Boston, MA 02118, USA. 4. Slone Epidemiology Center, Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA. 5. Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK. 6. Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 W 168th St, New York, NY 10032, USA.
Abstract
AIM: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. MATERIALS & METHODS: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. RESULTS: Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. CONCLUSION: NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.
AIM: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. MATERIALS & METHODS: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. RESULTS:Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. CONCLUSION:NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.
Entities:
Keywords:
African–Americans; CpG island shore; DNA methylation; NR3C1; abuse; child maltreatment; epigenetic epidemiology; glucocorticoid receptor; health disparities; violence
Authors: Valentina Bollati; Andrea Baccarelli; Lifang Hou; Matteo Bonzini; Silvia Fustinoni; Domenico Cavallo; Hyang-Min Byun; Jiayi Jiang; Barbara Marinelli; Angela C Pesatori; Pier A Bertazzi; Allen S Yang Journal: Cancer Res Date: 2007-02-01 Impact factor: 12.701
Authors: Simone R Alt; Jonathan D Turner; Melanie D Klok; Onno C Meijer; Egbert A J F Lakke; Roel H Derijk; Claude P Muller Journal: Psychoneuroendocrinology Date: 2009-09-25 Impact factor: 4.905
Authors: Patricia F Coogan; Lauren A Wise; George T O'Connor; Timothy A Brown; Julie R Palmer; Lynn Rosenberg Journal: J Allergy Clin Immunol Date: 2012-12-06 Impact factor: 10.793
Authors: Chantel L Martin; Lea Ghastine; Evans K Lodge; Radhika Dhingra; Cavin K Ward-Caviness Journal: Annu Rev Public Health Date: 2022-04-05 Impact factor: 21.870
Authors: M Austin Argentieri; Sairaman Nagarajan; Bobak Seddighzadeh; Andrea A Baccarelli; Alexandra E Shields Journal: EBioMedicine Date: 2017-04-04 Impact factor: 8.143
Authors: Paschalis Efstathopoulos; Filip Andersson; Philippe A Melas; Liu L Yang; J Carlos Villaescusa; Joëlle Rȕegg; Tomas J Ekström; Yvonne Forsell; Maria Rosaria Galanti; Catharina Lavebratt Journal: Transl Psychiatry Date: 2018-06-19 Impact factor: 6.222
Authors: Stephanie H Parade; Lindsay Huffhines; Nicole R Nugent; Audrey R Tyrka; Teresa E Daniels; Laura R Stroud Journal: Transl Psychiatry Date: 2021-02-19 Impact factor: 6.222
Authors: Alexandra E Dereix; Rachel Ledyard; Allyson M Redhunt; Tessa R Bloomquist; Kasey Jm Brennan; Andrea A Baccarelli; Michele R Hacker; Heather H Burris Journal: Epigenomics Date: 2020-11-20 Impact factor: 4.778
Authors: Erica T Warner; Ying Zhang; Yue Gu; Tâmara P Taporoski; Alexandre Pereira; Immaculata DeVivo; Nicholas D Spence; Yvette Cozier; Julie R Palmer; Alka M Kanaya; Namratha R Kandula; Shelley A Cole; Shelley Tworoger; Alexandra Shields Journal: PLoS One Date: 2020-10-30 Impact factor: 3.240