Literature DB >> 33197880

Colon cancer combined with obesity indicates improved survival- research on relevant mechanism.

Zhou Yang1, Xiyi Wei2, Yitong Pan3, Zhijun Min1, Jingyuan Xu1,4, Bo Yu1,5.   

Abstract

Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients' survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCGA) database. We confirmed obesity as an independent prognostic factor for improved overall survival of colon cancer patients. We demonstrated that hypoxia pathways were repressed in obese patients by regulating miR-210. Immune checkpoints PD-1 and LAG3 were also downregulated in obese patients, which indicated enhanced immune surveillance. The frequency of PIK3CA and KRAS mutations was decreased in obese patients. The sites and types of TP53 mutation were alternated in obesity patients. In conclusion, our research demonstrated the potential mechanisms of prolonged survival in colon cancer patients combined with obesity, which may provide potential value for improving the prognosis of colon cancer.

Entities:  

Keywords:  TP53; colon cancer; hypoxia; immune checkpoints; obesity

Mesh：

Substances：

Year:  2020        PMID： 33197880      PMCID： PMC7762486          DOI： 10.18632/aging.103972

Source DB:  PubMed          Journal:  Aging (Albany NY)        ISSN： 1945-4589            Impact factor:   5.682


  44 in total

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Journal:  Cell       Date:  2019-01-31       Impact factor: 41.582

Review 3.  Colorectal cancer.

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Journal:  Lancet       Date:  2010-03-20       Impact factor: 79.321

4.  Association between baseline body mass index and overall survival among patients over age 60 with acute myeloid leukemia.

Authors:  Andrew M Brunner; Hossein Sadrzadeh; Yang Feng; Benjamin J Drapkin; Karen K Ballen; Eyal C Attar; Philip C Amrein; Steven L McAfee; Yi-Bin Chen; Donna S Neuberg; Amir T Fathi
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5.  Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells.

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Journal:  Carcinogenesis       Date:  2009-08-20       Impact factor: 4.944

6.  PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.

Authors:  Andrea Sartore-Bianchi; Miriam Martini; Francesca Molinari; Silvio Veronese; Michele Nichelatti; Salvatore Artale; Federica Di Nicolantonio; Piercarlo Saletti; Sara De Dosso; Luca Mazzucchelli; Milo Frattini; Salvatore Siena; Alberto Bardelli
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8.  The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer.

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10.  Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.

Authors:  Krasimira Aleksandrova; Tobias Pischon; Brian Buijsse; Anne M May; Petra H Peeters; H Bas Bueno-de-Mesquita; Mazda Jenab; Veronika Fedirko; Christina C Dahm; Peter D Siersema; Heinz Freisling; Pietro Ferrari; Kim Overvad; Anne Tjønneland; Antonia Trichopoulou; Pagona Lagiou; Androniki Naska; Valeria Pala; Amalia Mattiello; Bodil Ohlsson; Karin Jirström; Timothy J Key; Kay-Tee Khaw; Elio Riboli; Heiner Boeing
Journal:  Eur J Cancer       Date:  2013-07-15       Impact factor: 9.162
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  4 in total

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Journal:  Turk J Gastroenterol       Date:  2022-04       Impact factor: 1.555

2.  The impact of body mass index on prognosis in patients with colon carcinoma.

Authors:  Julian Fuchs; Vera S Schellerer; Maximilian Brunner; Carol I Geppert; Robert Grützmann; Klaus Weber; Susanne Merkel
Journal:  Int J Colorectal Dis       Date:  2022-04-14       Impact factor: 2.796

3.  Prognostic value of mesorectal package area in patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy: A retrospective cohort study.

Authors:  Bingjie Guan; Xinmin Huang; Huang Xia; Guoxian Guan; Benhua Xu
Journal:  Front Oncol       Date:  2022-10-03       Impact factor: 5.738

4.  A hypoxia risk signature for the tumor immune microenvironment evaluation and prognosis prediction in acute myeloid leukemia.

Authors:  Feng Jiang; Yan Mao; Binbin Lu; Guoping Zhou; Jimei Wang
Journal:  Sci Rep       Date:  2021-07-19       Impact factor: 4.379
  4 in total

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