Nahed O ELHassan1,2, Sean G Young2,3, Yevgeniya Gokun2,4, Fei Wan2,4,5, Wendy N Nembhard2,6. 1. Department of Pediatrics (Neonatology), Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 2. Arkansas Center for Birth Defects Research and Prevention, Little Rock, Arkansas, USA. 3. Department of Environmental and Occupational Health, Fay W. Boozman College of Public Heath, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 4. Department of Biostatistics, Fay W. Boozman College of Public Heath, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 5. Division of Public Health Sciences, Washington University in St. Louis, St Louis, Missouri, USA. 6. Department of Epidemiology, Fay W. Boozman College of Public Heath, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Abstract
BACKGROUND: Arkansas (AR) had the highest prevalence of gastroschisis in a recent study including 15 U.S. states. Our objective was to evaluate trends in prevalence and the spatiotemporal distribution of gastroschisis in AR. METHODS: Infants with gastroschisis, born 1998-2015, were identified from the Arkansas Reproductive Health Monitoring System. Birth record data were used as denominators for calculations. Maternal residence at delivery was geocoded for spatial analyses. Annual prevalence rates (PRs) were calculated. Joinpoint regression analysis was performed to examine trends in gastroschisis and report the annual percent changes (APCs) in PRs. Spatiotemporal analyses identified counties with unusually high PRs of gastroschisis. Poisson regression, including county, year, and county*year indicators, was fit to evaluate the PRs of gastroschisis, while adjusting for county-level maternal variables. RESULTS: We identified 401 cases of gastroschisis among 694,459 live births. The overall PR of gastroschisis was 5.8/10,000 live births. The prevalence of gastroschisis had a significant APC of +5.3% (p < .0001) between 1998 and 2012, followed by a nonsignificant yearly average decrease of -17% through 2015 (p = 0.2). The Emerging Hot Spot Analysis and SaTScan identified an overlapping five-county cluster from 2006 to 2013. Poisson regression model, including county (inside vs. outside cluster), time (before vs. after 2006), and county*time indicators, was fit to evaluate the PRs of gastroschisis. The model did not confirm the presence of a spatiotemporal cluster, once it adjusted for county-level maternal characteristics (p = .549). CONCLUSION: Close monitoring of rates of gastroschisis is warranted to determine if the PRs of gastroschisis continue to decline in AR.
BACKGROUND: Arkansas (AR) had the highest prevalence of gastroschisis in a recent study including 15 U.S. states. Our objective was to evaluate trends in prevalence and the spatiotemporal distribution of gastroschisis in AR. METHODS: Infants with gastroschisis, born 1998-2015, were identified from the Arkansas Reproductive Health Monitoring System. Birth record data were used as denominators for calculations. Maternal residence at delivery was geocoded for spatial analyses. Annual prevalence rates (PRs) were calculated. Joinpoint regression analysis was performed to examine trends in gastroschisis and report the annual percent changes (APCs) in PRs. Spatiotemporal analyses identified counties with unusually high PRs of gastroschisis. Poisson regression, including county, year, and county*year indicators, was fit to evaluate the PRs of gastroschisis, while adjusting for county-level maternal variables. RESULTS: We identified 401 cases of gastroschisis among 694,459 live births. The overall PR of gastroschisis was 5.8/10,000 live births. The prevalence of gastroschisis had a significant APC of +5.3% (p < .0001) between 1998 and 2012, followed by a nonsignificant yearly average decrease of -17% through 2015 (p = 0.2). The Emerging Hot Spot Analysis and SaTScan identified an overlapping five-county cluster from 2006 to 2013. Poisson regression model, including county (inside vs. outside cluster), time (before vs. after 2006), and county*time indicators, was fit to evaluate the PRs of gastroschisis. The model did not confirm the presence of a spatiotemporal cluster, once it adjusted for county-level maternal characteristics (p = .549). CONCLUSION: Close monitoring of rates of gastroschisis is warranted to determine if the PRs of gastroschisis continue to decline in AR.
Authors: Victor M Salinas-Torres; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; Laura E Martínez-de-Villarreal Journal: J Pediatr Adolesc Gynecol Date: 2018-01-06 Impact factor: 1.814
Authors: Monica Rittler; Hebe Campaña; Monica L Ermini; Juan A Gili; Fernando A Poletta; Mariela S Pawluk; Lucas G Giménez; Viviana R Cosentino; Eduardo E Castilla; Jorge S López-Camelo Journal: Birth Defects Res A Clin Mol Teratol Date: 2015-04-06
Authors: Joanne E Given; Maria Loane; Ester Garne; Vera Nelen; Ingeborg Barisic; Hanitra Randrianaivo; Babak Khoshnood; Awi Wiesel; Anke Rissmann; Catherine Lynch; Amanda J Neville; Anna Pierini; Marian Bakker; Kari Klungsoyr; Anna Latos Bielenska; Clara Cavero-Carbonell; Marie-Claude Addor; Natalya Zymak-Zakutnya; David Tucker; Helen Dolk Journal: Paediatr Perinat Epidemiol Date: 2017-08-25 Impact factor: 3.980
Authors: Hyune-Ju Kim; Jun Luo; Huann-Sheng Chen; Don Green; Dennis Buckman; Jeffrey Byrne; Eric J Feuer Journal: Stat Med Date: 2017-06-05 Impact factor: 2.373
Authors: Maria Loane; Helen Dolk; Alan Kelly; Conor Teljeur; Ruth Greenlees; James Densem Journal: Birth Defects Res A Clin Mol Teratol Date: 2011-03-04