Frédéric Bargy1, Sylvie Beaudoin. 1. Department of Anatomy and Morphogenesis, Institut d'Anatomie des Saints Pères, Université Paris Descartes, Paris, France.
Abstract
INTRODUCTION: The development of gastroschisis remains an area of controversy. Various theories have been proposed, but none has ever been supported by a thorough embryological study. MATERIAL AND METHODS: We herein report anatomical and microscopic observations of the developing abdominal wall and cord of embryos and fetuses, along with clinical features of gastroschisis. RESULTS: It appears that the developing cord normally has two parts, a firm left-sided part formed by the vessels and urachus, and a thin right-sided pouch covering the intestinal loops (the 'physiological umbilical hernia'), which could rupture, giving the basis of gastroschisis. DISCUSSION: Gastroschisis could be the result of amniotic damage, possibly from some as yet unidentified toxin. Further bowel damage can be explained by the subsequent mesenteric injury.
INTRODUCTION: The development of gastroschisis remains an area of controversy. Various theories have been proposed, but none has ever been supported by a thorough embryological study. MATERIAL AND METHODS: We herein report anatomical and microscopic observations of the developing abdominal wall and cord of embryos and fetuses, along with clinical features of gastroschisis. RESULTS: It appears that the developing cord normally has two parts, a firm left-sided part formed by the vessels and urachus, and a thin right-sided pouch covering the intestinal loops (the 'physiological umbilical hernia'), which could rupture, giving the basis of gastroschisis. DISCUSSION: Gastroschisis could be the result of amniotic damage, possibly from some as yet unidentified toxin. Further bowel damage can be explained by the subsequent mesenteric injury.
Authors: Víctor M Salinas-Torres; Hugo L Gallardo-Blanco; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; José J Lugo-Trampe; Daniel Z Villarreal-Martínez; Laura E Martínez de Villarreal Journal: Int J Mol Sci Date: 2019-05-09 Impact factor: 5.923
Authors: Elisabeth Pechriggl; Michael Blumer; R Shane Tubbs; Łukasz Olewnik; Marko Konschake; René Fortélny; Hannes Stofferin; Hanne Rose Honis; Sara Quinones; Eva Maranillo; José Sanudo Journal: Front Surg Date: 2022-07-07
Authors: Nynke Spinder; Lynn M Almli; Tania A Desrosiers; Kathryn E Arnold; Jorieke E H Bergman; Hans Kromhout; H Marike Boezen; Hermien E K de Walle; Carissa Rocheleau; Jennita Reefhuis Journal: Occup Environ Med Date: 2020-01-16 Impact factor: 4.402
Authors: Sandra Pütz; Lisa Sophie Barthel; Marina Frohn; Doris Metzler; Mohammed Barham; Galyna Pryymachuk; Oliver Trunschke; Lubomir T Lubomirov; Jürgen Hescheler; Joseph M Chalovich; Wolfram F Neiss; Manuel Koch; Mechthild M Schroeter; Gabriele Pfitzer Journal: J Gen Physiol Date: 2021-06-11 Impact factor: 4.086