Literature DB >> 33172265

Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.

Kouharu Otsuki1, Mi Zhang1, Asuka Yamamoto1, Minami Tsuji1, Miyuko Tejima1, Zi-Song Bai2, Di Zhou2, Li Huang3, Chin-Ho Chen3, Kuo-Hsiung Lee4,5, Ning Li2, Wei Li1, Kazuo Koike1.   

Abstract

During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC50 values of 3.8 and 12.8 nM, respectively.

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Year:  2020        PMID： 33172265      PMCID： PMC8176626          DOI： 10.1021/acs.jnatprod.0c00700

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

1.  Three new 1α-alkyldaphnane-type diterpenoids from the flower buds of Wikstroemia chamaedaphne.

Authors:  Jieru Guo; Jun Tian; Guangmin Yao; Hucheng Zhu; Yongbo Xue; Zengwei Luo; Jinwen Zhang; Yuan Zhang; Yonghui Zhang
Journal:  Fitoterapia       Date:  2015-09-21       Impact factor: 2.882

Review 2.  Tigliane diterpenoids from the Euphorbiaceae and Thymelaeaceae families.

Authors:  Hong-Bing Wang; Xiao-Yang Wang; Li-Ping Liu; Guo-Wei Qin; Ting-Guo Kang
Journal:  Chem Rev       Date:  2015-04-23       Impact factor: 60.622

3.  Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.

Authors:  Yoshihisa Asada; Aya Sukemori; Takashi Watanabe; Kuber J Malla; Takafumi Yoshikawa; Wei Li; Kazuo Koike; Chin-Ho Chen; Toshiyuki Akiyama; Keduo Qian; Kyoko Nakagawa-Goto; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Org Lett       Date:  2011-05-11       Impact factor: 6.005

4.  Chemical Constituents from the Stems of Daphne holosericea (Diels) Hamaya.

Authors:  Qing-Yun Ma; Yi-Chun Chen; Sheng-Zhuo Huang; Fan-Dong Kong; Li-Man Zhou; Hao-Fu Dai; Yan Hua; You-Xing Zhao
Journal:  Chem Biodivers       Date:  2016-10-08       Impact factor: 2.408

5.  Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART.

Authors:  J Kulkosky; D M Culnan; J Roman; G Dornadula; M Schnell; M R Boyd; R J Pomerantz
Journal:  Blood       Date:  2001-11-15       Impact factor: 22.113

6.  Minor daphnane-type diterpenoids from Wikstroemia retusa.

Authors:  F Abe; Y Iwase; T Yamauchi; K Kinjo; S Yaga; M Ishii; M Iwahana
Journal:  Phytochemistry       Date:  1998-03       Impact factor: 4.072

7.  Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

Authors:  Yoshihisa Asada; Aya Sukemori; Takashi Watanabe; Kuber J Malla; Takafumi Yoshikawa; Wei Li; Xinzhu Kuang; Kazuo Koike; Chin-Ho Chen; Toshiyuki Akiyama; Keduo Qian; Kyoko Nakagawa-Goto; Susan L Morris-Natschke; Yan Lu; Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2013-04-23       Impact factor: 4.050

8.  Anti-HIV tigliane diterpenoids from Reutealis trisperma.

Authors:  Yan Lu; Ya-Si Huang; Chin-Ho Chen; Toshiyuki Akiyama; Susan L Morris-Natschke; Yung-Yi Cheng; Ih-Sheng Chen; Sheng-Zehn Yang; Dao-Feng Chen; Kuo-Hsiung Lee
Journal:  Phytochemistry       Date:  2020-03-28       Impact factor: 4.072

9.  Flavones and Lignans from the Stems of Wikstroemia scytophylla Diels.

Authors:  Jie-Ping Lei; Juan-Juan Yuan; Sheng-Hao Pi; Rui Wang; Rui Tan; Chao-Ying Ma; Tao Zhang; He-Zhong Jiang
Journal:  Pharmacogn Mag       Date:  2017-07-19       Impact factor: 1.085

10.  Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC-46).

Authors:  Thomas R De Ridder; Justine E Campbell; Cheryl Burke-Schwarz; David Clegg; Emily L Elliot; Samuel Geller; Wendy Kozak; Stephen T Pittenger; Jennifer B Pruitt; Jocelyn Riehl; Julie White; Melissa L Wiest; Chad M Johannes; John Morton; Pamela D Jones; Peter F Schmidt; Victoria Gordon; Paul Reddell
Journal:  J Vet Intern Med       Date:  2020-06-16       Impact factor: 3.175
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  1 in total

1.  A feruloylated acylglycerol isolated from Wikstroemia pilosa and its distribution in ten plants of Wikstroemia species.

Authors:  Mi Zhang; Kouharu Otsuki; Shizuka Kato; Yuito Ikuma; Takashi Kikuchi; Ning Li; Kazuo Koike; Wei Li
Journal:  J Nat Med       Date:  2022-03-30       Impact factor: 2.343
  1 in total

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