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Literature DB >> 21561135

Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.

Yoshihisa Asada¹, Aya Sukemori, Takashi Watanabe, Kuber J Malla, Takafumi Yoshikawa, Wei Li, Kazuo Koike, Chin-Ho Chen, Toshiyuki Akiyama, Keduo Qian, Kyoko Nakagawa-Goto, Susan L Morris-Natschke, Kuo-Hsiung Lee.

Abstract

Three novel 1-alkyldaphnane-type diterpenes, stelleralides A-C (4-6), and five known compounds were isolated from the roots of Stellera chamaejasme L. The structures of 4-6 were elucidated by extensive spectroscopic analyses. Several isolated compounds showed potent anti-HIV activity. Compound 4 showed extremely potent anti-HIV activity (EC(90) 0.40 nM) with the lowest cytotoxicity (IC(50) 4.3 μM) and appears to be a promising compound for development into anti-AIDS clinical trial candidates.

Entities: CellLine Chemical Disease Species

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Year: 2011 PMID： 21561135 PMCID： PMC3109985 DOI： 10.1021/ol200889s

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

14 in total

1. Antimitotic and antifungal C-3/C-3''-biflavanones from Stellera chamaejasme.

Authors: Guohong Yang; Zhixin Liao; Zhiyong Xu; Huiping Zhang; Daofeng Chen
Journal: Chem Pharm Bull (Tokyo) Date: 2005-07 Impact factor: 1.645

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Authors: Zhi-Hong Jiang; Takashi Tanaka; Takako Sakamoto; Isao Kouno; Jin-Ao Duan; Rong-Han Zhou
Journal: Chem Pharm Bull (Tokyo) Date: 2002-01 Impact factor: 1.645

3. Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals.

Authors: Ling Zhang; Rong-Hua Luo; Fei Wang; Ze-Jun Dong; Liu-Meng Yang; Yong-Tang Zheng; Ji-Kai Liu
Journal: Phytochemistry Date: 2010-11 Impact factor: 4.072

4. Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART.

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Journal: Blood Date: 2001-11-15 Impact factor: 22.113

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Journal: Phytochemistry Date: 1998-03 Impact factor: 4.072

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Authors: Sven Bocklandt; Peter M Blumberg; Dean H Hamer
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10. Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue.

Authors: Angélique Biancotto; Jean-Charles Grivel; Françoise Gondois-Rey; Lise Bettendroffer; Robert Vigne; Stephen Brown; Leonid B Margolis; Ivan Hirsch
Journal: J Virol Date: 2004-10 Impact factor: 5.103

18 in total

1. Anti-inflammatory and anti-angiogenic activities in vitro of eight diterpenes from Daphne genkwa based on hierarchical cluster and principal component analysis.

Authors: Ling Wang; Xin-Yi Lan; Jun Ji; Chun-Feng Zhang; Fei Li; Chong-Zhi Wang; Chun-Su Yuan
Journal: J Nat Med Date: 2018-04-21 Impact factor: 2.343

2. Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from Daphne odora.

Authors: Kouharu Otsuki; Wei Li; Yoshihisa Asada; Chin-Ho Chen; Kuo-Hsiung Lee; Kazuo Koike
Journal: Org Lett Date: 2019-11-04 Impact factor: 6.005

3. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.

Authors: Li Huang; Wei-Hong Lai; Lei Zhu; Wei Li; Lei Wei; Kuo-Hsiung Lee; Lan Xie; Chin-Ho Chen
Journal: ACS Med Chem Lett Date: 2018-02-06 Impact factor: 4.345

4. Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

Authors: Yoshihisa Asada; Aya Sukemori; Takashi Watanabe; Kuber J Malla; Takafumi Yoshikawa; Wei Li; Xinzhu Kuang; Kazuo Koike; Chin-Ho Chen; Toshiyuki Akiyama; Keduo Qian; Kyoko Nakagawa-Goto; Susan L Morris-Natschke; Yan Lu; Kuo-Hsiung Lee
Journal: J Nat Prod Date: 2013-04-23 Impact factor: 4.050

5. Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.

Authors: Kouharu Otsuki; Mi Zhang; Takashi Kikuchi; Minami Tsuji; Miyuko Tejima; Zi-Song Bai; Di Zhou; Li Huang; Chin-Ho Chen; Kuo-Hsiung Lee; Ning Li; Kazuo Koike; Wei Li
Journal: J Nat Med Date: 2021-07-21 Impact factor: 2.343