| Literature DB >> 26393897 |
Jieru Guo1, Jun Tian2, Guangmin Yao3, Hucheng Zhu3, Yongbo Xue3, Zengwei Luo3, Jinwen Zhang4, Yuan Zhang5, Yonghui Zhang6.
Abstract
Three new 1α-alkyldaphnane type diterpenoids, wikstroelides R-T (1-3), together with three known analogs, genkwadane C (4), pimelea factors S6 (5) and S7 (6), two known 1α-alkyldaphnane ketal-lactone type diterpenoids, pimelotides A (7) and C (8), and a known daphnane type diterpenoid, simplexin (9), were isolated from the flower buds of Wikstroemia chamaedaphne. Their structures were elucidated by a combination of spectroscopic analyses including HRESIMS and NMR. Compounds 1-9 were evaluated for their cytotoxic activities in vitro, and most of them exhibited moderate cytotoxic activities with IC50 values ranging from 8.7-22.0 μM.Entities:
Keywords: Cytotoxicity; Diterpenoid; Wikstroemia chamaedaphne
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Year: 2015 PMID： 26393897 DOI： 10.1016/j.fitote.2015.09.017
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882