Claudio T Mesquita1, Amalia Peix2, Fernando de Amorim Fernandes3, Raffaele Giubbini4, Ganesan Karthikeyan5, Teresa Massardo6, Chetan Patel5, Luz M Pabon7, Amelia Jimenez-Heffernan8, Erick Alexanderson9, Sadaf Butt10, Alka Kumar11, Victor Marin12, Olga Morozova13, Diana Paez13, Ernest V Garcia14. 1. Hospital Universitario Antonio Pedro-Ebeserh UFF, Niteroi, 24033-900, Brazil. claudiotinocomesquita@id.uff.br. 2. Nuclear Medicine Department, Institute of Cardiology, La Habana, Cuba. 3. Hospital Universitario Antonio Pedro-Ebeserh UFF, Niteroi, 24033-900, Brazil. 4. Nuclear Medicine, Spedali Civili, Brescia, Italy. 5. All India Institute of Medical Sciences, New Delhi, India. 6. Hospital Clinico Universidad de Chile, Santiago, Chile. 7. Fundacion Valle del Lili, Cali, Colombia. 8. Hospital Juan Ramon Jimenez, Huelva, Spain. 9. Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, DF, Mexico. 10. Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan. 11. Dr. B L Kapur Memorial Hospital, New Delhi, India. 12. Fundacion Cardioinfantil, Bogota, Colombia. 13. Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy Agency, Vienna, Austria. 14. Emory University, Atlanta, GA, USA.
Abstract
PURPOSE: We sought to evaluate the behavior of cardiac mechanical synchrony as measured by phase SD (PSD) derived from gated MPI SPECT (gSPECT) in patients with super-response after CRT and to evaluate the clinical and imaging characteristics associated with super-response. METHODS: 158 subjects were evaluated with gSPECT before and 6 months after CRT. Patients with an improvement of LVEF > 15% and NYHA class I/II or reduction in LV end-systolic volume > 30% and NYHA class I/II were labeled as super-responders (SR). RESULTS: 34 patients were classified as super-responders (22%) and had lower PSD (32° ± 17°) at 6 months after CRT compared to responders (45° ± 24°) and non-responders 46° ± 28° (P = .02 for both comparisons). Regression analysis identified predictors independently associated with super-response to CRT: absence of previous history of CAD (odds ratio 18.7; P = .002), absence of diabetes mellitus (odds ratio 13; P = .03), and history of hypertension (odds ratio .2; P = .01). CONCLUSION: LV dyssynchrony after CRT implantation, but not at baseline, was significantly better among super-responders compared to non-super-responders. The absence of diabetes, absence of CAD, and history of hypertension were independently associated with super-response after CRT.
PURPOSE: We sought to evaluate the behavior of cardiac mechanical synchrony as measured by phase SD (PSD) derived from gated MPI SPECT (gSPECT) in patients with super-response after CRT and to evaluate the clinical and imaging characteristics associated with super-response. METHODS: 158 subjects were evaluated with gSPECT before and 6 months after CRT. Patients with an improvement of LVEF > 15% and NYHA class I/II or reduction in LV end-systolic volume > 30% and NYHA class I/II were labeled as super-responders (SR). RESULTS: 34 patients were classified as super-responders (22%) and had lower PSD (32° ± 17°) at 6 months after CRT compared to responders (45° ± 24°) and non-responders 46° ± 28° (P = .02 for both comparisons). Regression analysis identified predictors independently associated with super-response to CRT: absence of previous history of CAD (odds ratio 18.7; P = .002), absence of diabetes mellitus (odds ratio 13; P = .03), and history of hypertension (odds ratio .2; P = .01). CONCLUSION: LV dyssynchrony after CRT implantation, but not at baseline, was significantly better among super-responders compared to non-super-responders. The absence of diabetes, absence of CAD, and history of hypertension were independently associated with super-response after CRT.
Authors: Jonathan C Hsu; Scott D Solomon; Mikhail Bourgoun; Scott McNitt; Ilan Goldenberg; Helmut Klein; Arthur J Moss; Elyse Foster Journal: J Am Coll Cardiol Date: 2012-06-19 Impact factor: 24.094
Authors: Zhuo He; Fernando de Amorim Fernandes; Erivelton Alessandro do Nascimento; Ernest V Garcia; Claudio T Mesquita; Weihua Zhou Journal: J Nucl Cardiol Date: 2021-01-27 Impact factor: 3.872
Authors: Ricardo Ruiz-Villaverde; Javier Domínguez-Cruz; Francisco J Navarro-Triviño; Manuel Galán-Gutiérrez; Jose Carlos Armario-Hita; Jose Juan Pereyra-Rodriguez Journal: Life (Basel) Date: 2022-08-04