Sehnaz Evrimler1,2, Jordan K Swensson1, Vijay S Are3, Temel Tirkes1, Raj Vuppalanchi4, Fatih Akisik5. 1. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N University Blvd Room 0663, Indianapolis, IN, 46202, USA. 2. Department of Radiology, Suleyman Demirel University School of Medicine, East Campus, Cunur, 32260, Isparta, Turkey. 3. Department of Gastroenterology and Hepatology, Indiana University School of Medicine, 702 Rotary Circle Room 225, Indianapolis, IN, 46202, USA. 4. Department of Gastroenterology and Hepatology, Indiana University School of Medicine, 550 N University Blvd Room 1710, Indianapolis, IN, 46202, USA. 5. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N University Blvd Room 0663, Indianapolis, IN, 46202, USA. makisik@iupui.edu.
Abstract
PURPOSE: Assess the relationship between liver T1 relaxation time and extracellular volume (ECV) fraction and the disease severity of primary sclerosing cholangitis (PSC). METHODS: This retrospective study included 93 patients with PSC and 66 healthy patients in the control group. T1 relaxation times were measured in the right and left lobe, as well as in the area of stricture. T1PSC and ECVPSC were calculated by averaging T1 and ECV of both lobes and stricture site. T1 and ECV were compared between the two groups and according to PSC phenotypes and severity based on Mayo Risk Score (MRS). We also examined the relationship between T1 and ECV with non-invasive measures of fibrosis such as Fibrosis-4 index (FIB-4) and liver stiffness measurement (LSM) by transient elastography. RESULTS: Mean liver T1 (774 ± 111 ms, p < 0.001) and liver ECV (0.40 ± 0.14, p < 0.05) were significantly higher with both large-duct and small-duct-type PSC which may lack classic imaging findings on MRCP compared to the control group (p < 0.001). T1PSC and ECVPSC showed weak-moderate correlation with LSM, FIB-4, and MRS (p < 0.05). Cut-off values of liver T1 to detect patients in low-risk and high-risk MRS groups were 677 ms (AUC: 0.68, sensitivity: 76%, specificity: 53%, p = 0.03) and 743 ms (AUC: 0.83, sensitivity: 79%, specificity: 76%, p < 0.001), respectively. CONCLUSION: T1 relaxation time and ECV fraction can be used for quantitative assessment of disease severity in patients with PSC.
PURPOSE: Assess the relationship between liver T1 relaxation time and extracellular volume (ECV) fraction and the disease severity of primary sclerosing cholangitis (PSC). METHODS: This retrospective study included 93 patients with PSC and 66 healthy patients in the control group. T1 relaxation times were measured in the right and left lobe, as well as in the area of stricture. T1PSC and ECVPSC were calculated by averaging T1 and ECV of both lobes and stricture site. T1 and ECV were compared between the two groups and according to PSC phenotypes and severity based on Mayo Risk Score (MRS). We also examined the relationship between T1 and ECV with non-invasive measures of fibrosis such as Fibrosis-4 index (FIB-4) and liver stiffness measurement (LSM) by transient elastography. RESULTS: Mean liver T1 (774 ± 111 ms, p < 0.001) and liver ECV (0.40 ± 0.14, p < 0.05) were significantly higher with both large-duct and small-duct-type PSC which may lack classic imaging findings on MRCP compared to the control group (p < 0.001). T1PSC and ECVPSC showed weak-moderate correlation with LSM, FIB-4, and MRS (p < 0.05). Cut-off values of liver T1 to detect patients in low-risk and high-risk MRS groups were 677 ms (AUC: 0.68, sensitivity: 76%, specificity: 53%, p = 0.03) and 743 ms (AUC: 0.83, sensitivity: 79%, specificity: 76%, p < 0.001), respectively. CONCLUSION: T1 relaxation time and ECV fraction can be used for quantitative assessment of disease severity in patients with PSC.
Authors: Julian A Luetkens; Sabine Klein; Frank Träber; Frederic C Schmeel; Alois M Sprinkart; Daniel L R Kuetting; Wolfgang Block; Frank E Uschner; Robert Schierwagen; Kanishka Hittatiya; Glen Kristiansen; Juergen Gieseke; Hans H Schild; Jonel Trebicka; Guido M Kukuk Journal: Radiology Date: 2018-06-26 Impact factor: 11.105
Authors: C Weber; R Kuhlencordt; R Grotelueschen; U Wedegaertner; T L Ang; G Adam; N Soehendra; U Seitz Journal: Endoscopy Date: 2008-08-12 Impact factor: 10.093
Authors: Leah Iles; Heinz Pfluger; Arintaya Phrommintikul; Joshi Cherayath; Pelin Aksit; Sandeep N Gupta; David M Kaye; Andrew J Taylor Journal: J Am Coll Cardiol Date: 2008-11-04 Impact factor: 24.094
Authors: Sairia Dass; Joseph J Suttie; Stefan K Piechnik; Vanessa M Ferreira; Cameron J Holloway; Rajarshi Banerjee; Masliza Mahmod; Lowri Cochlin; Theodoros D Karamitsos; Matthew D Robson; Hugh Watkins; Stefan Neubauer Journal: Circ Cardiovasc Imaging Date: 2012-10-15 Impact factor: 7.792
Authors: Temel Tirkes; Dhiraj Yadav; Darwin L Conwell; Paul R Territo; Xuandong Zhao; Scott A Persohn; Anil K Dasyam; Zarine K Shah; Sudhakar K Venkatesh; Naoki Takahashi; Ashley Wachsman; Liang Li; Yan Li; Stephen J Pandol; Walter G Park; Santhi S Vege; Phil A Hart; Mark Topazian; Dana K Andersen; Evan L Fogel Journal: Abdom Radiol (NY) Date: 2022-08-29