Literature DB >> 33125710

IFITM3-specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans.

Dannielle Wellington1,2, Zixi Yin1,2, Adi Abdel-Haq1,3, Liwei Zhang1, Jessica Forbester1,4, Kerry Kite1, Ushani Rajapaksa1, Henry Laurenson-Schafer1, Shokouh Makvandi-Nejad1, Boquan Jin5, Emma Bowes6, Krishnageetha Manoharan6, David Maldonado-Perez6, Clare Verrill6, Ian R Humphreys4, Tao Dong1,2.   

Abstract

Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells.
© 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

Entities:  

Keywords:  IFITM3; IFN; innate immunity; myeloid cells; viral restriction

Year:  2020        PMID： 33125710      PMCID： PMC7983929          DOI： 10.1002/eji.202048706

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  8 in total

Review 1.  Complex roles of Stat1 in regulating gene expression.

Authors:  C V Ramana; M Chatterjee-Kishore; H Nguyen; G R Stark
Journal:  Oncogene       Date:  2000-05-15       Impact factor: 9.867

2.  Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway.

Authors:  Aoife Kelly; Mark W Robinson; Gerard Roche; Christine A Biron; Cliona O'Farrelly; Elizabeth J Ryan
Journal:  J Interferon Cytokine Res       Date:  2016-09-12       Impact factor: 2.607

Review 3.  BST-2/tetherin: a new component of the innate immune response to enveloped viruses.

Authors:  David T Evans; Ruth Serra-Moreno; Rajendra K Singh; John C Guatelli
Journal:  Trends Microbiol       Date:  2010-08-03       Impact factor: 17.079

4.  Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Authors:  Xianfang Wu; Viet Loan Dao Thi; Yumin Huang; Eva Billerbeck; Debjani Saha; Hans-Heinrich Hoffmann; Yaomei Wang; Luis A Vale Silva; Stephanie Sarbanes; Tony Sun; Linda Andrus; Yingpu Yu; Corrine Quirk; Melody Li; Margaret R MacDonald; William M Schneider; Xiuli An; Brad R Rosenberg; Charles M Rice
Journal:  Cell       Date:  2017-12-14       Impact factor: 41.582

5.  Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

Authors:  I-Chueh Huang; Charles C Bailey; Jessica L Weyer; Sheli R Radoshitzky; Michelle M Becker; Jessica J Chiang; Abraham L Brass; Asim A Ahmed; Xiaoli Chi; Lian Dong; Lindsay E Longobardi; Dutch Boltz; Jens H Kuhn; Stephen J Elledge; Sina Bavari; Mark R Denison; Hyeryun Choe; Michael Farzan
Journal:  PLoS Pathog       Date:  2011-01-06       Impact factor: 6.823

6.  The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

Authors:  Abraham L Brass; I-Chueh Huang; Yair Benita; Sinu P John; Manoj N Krishnan; Eric M Feeley; Bethany J Ryan; Jessica L Weyer; Louise van der Weyden; Erol Fikrig; David J Adams; Ramnik J Xavier; Michael Farzan; Stephen J Elledge
Journal:  Cell       Date:  2009-12-24       Impact factor: 41.582

7.  Ifitm3 limits the severity of acute influenza in mice.

Authors:  Charles C Bailey; I-Chueh Huang; Christina Kam; Michael Farzan
Journal:  PLoS Pathog       Date:  2012-09-06       Impact factor: 6.823

Review 8.  The IFITM protein family in adaptive immunity.

Authors:  Diana C Yánez; Susan Ross; Tessa Crompton
Journal:  Immunology       Date:  2019-12-22       Impact factor: 7.397
  8 in total
  2 in total

1.  Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods.

Authors:  Lei Chen; Zi Mei; Wei Guo; ShiJian Ding; Tao Huang; Yu-Dong Cai
Journal:  Biomed Res Int       Date:  2022-04-28       Impact factor: 3.246

2.  IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.

Authors:  M Clement; J L Forbester; M Marsden; P Sabberwal; M S Sommerville; D Wellington; S Dimonte; S Clare; K Harcourt; Z Yin; L Nobre; R Antrobus; B Jin; M Chen; S Makvandi-Nejad; J A Lindborg; S M Strittmatter; M P Weekes; R J Stanton; T Dong; I R Humphreys
Journal:  Nat Commun       Date:  2022-09-08       Impact factor: 17.694
  2 in total

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