| Literature DB >> 29249360 |
Xianfang Wu1, Viet Loan Dao Thi1, Yumin Huang2, Eva Billerbeck1, Debjani Saha3, Hans-Heinrich Hoffmann1, Yaomei Wang4, Luis A Vale Silva5, Stephanie Sarbanes1, Tony Sun1, Linda Andrus1, Yingpu Yu1, Corrine Quirk1, Melody Li1, Margaret R MacDonald1, William M Schneider1, Xiuli An4, Brad R Rosenberg3, Charles M Rice6.
Abstract
Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previously classified as interferon (IFN) stimulated genes (ISGs) but that expression is intrinsic, as stem cells are refractory to interferon. This intrinsic ISG expression varies in a cell-type-specific manner, and many ISGs decrease upon differentiation, at which time cells become IFN responsive, allowing induction of a broad spectrum of ISGs by IFN signaling. Importantly, we show that intrinsically expressed ISGs protect stem cells against viral infection. We demonstrate the in vivo importance of intrinsic ISG expression for protecting stem cells and their differentiation potential during viral infection. These findings have intriguing implications for understanding stem cell biology and the evolution of pathogen resistance.Entities:
Keywords: antiviral mechanisms; interferon-stimulated genes; intrinsic immunity; stem cell differentiation; tissue stem cells; tissue tropism; viral infection
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Year: 2017 PMID： 29249360 PMCID： PMC5786493 DOI： 10.1016/j.cell.2017.11.018
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582