Literature DB >> 33109725

rs1769793 variant reduces EGLN1 expression in skeletal muscle and hippocampus and contributes to high aerobic capacity in hypoxia.

Guiyou Liu1,2,3, Wenbo Zhao2, Haihua Zhang4,3, Tao Wang5,6, Zhifa Han7,8,9,10, Xunming Ji1,2,3,11,12.   

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Year:  2020        PMID： 33109725      PMCID： PMC7703601          DOI： 10.1073/pnas.2010073117

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  10 in total

1.  Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1.

Authors:  Kenneth K W To; L Eric Huang
Journal:  J Biol Chem       Date:  2005-09-12       Impact factor: 5.157

2.  Genetic variant rs17185536 regulates SIM1 gene expression in human brain hypothalamus.

Authors:  Guiyou Liu; Yang Hu; Zhifa Han; Shuilin Jin; Qinghua Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2019-02-12       Impact factor: 11.205

3.  Disease status affects the association between rs4813620 and the expression of Alzheimer's disease susceptibility gene TRIB3.

Authors:  Guiyou Liu; Shuilin Jin; Yang Hu; Qinghua Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-24       Impact factor: 11.205

Review 4.  The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks.

Authors:  Mircea Ivan; William G Kaelin
Journal:  Mol Cell       Date:  2017-06-15       Impact factor: 17.970

5.  Autoimmune disease variants regulate GSDMB gene expression in human immune cells and whole blood.

Authors:  Yang Hu; Shuilin Jin; Liang Cheng; Guiyou Liu; Qinghua Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2017-09-07       Impact factor: 11.205

6.  Rs2293871 regulates HTRA1 expression and affects cerebral small vessel stroke and Alzheimer's disease.

Authors:  Guiyou Liu; Haihua Zhang; Bian Liu; Xunming Ji
Journal:  Brain       Date:  2019-11-01       Impact factor: 13.501

7.  Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude.

Authors:  Tom D Brutsaert; Melisa Kiyamu; Gianpietro Elias Revollendo; Jenna L Isherwood; Frank S Lee; Maria Rivera-Ch; Fabiola Leon-Velarde; Sudipta Ghosh; Abigail W Bigham
Journal:  Proc Natl Acad Sci U S A       Date:  2019-11-11       Impact factor: 11.205

8.  EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Authors:  Benjamin A Olenchock; Javid Moslehi; Alan H Baik; Shawn M Davidson; Jeremy Williams; William J Gibson; Abhishek A Chakraborty; Kerry A Pierce; Christine M Miller; Eric A Hanse; Ameeta Kelekar; Lucas B Sullivan; Amy J Wagers; Clary B Clish; Matthew G Vander Heiden; William G Kaelin
Journal:  Cell       Date:  2016-02-25       Impact factor: 41.582

Review 9.  rs4147929 variant minor allele increases ABCA7 gene expression and ABCA7 shows increased gene expression in Alzheimer's disease patients compared with controls.

Authors:  Guiyou Liu; Haihua Zhang; Bian Liu; Tao Wang; Zhifa Han; Xunming Ji
Journal:  Acta Neuropathol       Date:  2020-02-29       Impact factor: 15.887

10.  Genetic effects on gene expression across human tissues.

Authors:  Alexis Battle; Christopher D Brown; Barbara E Engelhardt; Stephen B Montgomery
Journal:  Nature       Date:  2017-10-11       Impact factor: 49.962
  10 in total
  1 in total

1.  Reply to Liu et al.: The Andean EGLN1 adaptive allele could be a loss of function variant that increases HIF1-α in skeletal muscle.

Authors:  Tom D Brutsaert; Melissa Kiyamu; Gianpietro Elias Revollendo; Jenna L Isherwood; Frank S Lee; Maria Rivera-Ch; Fabiola Leon-Velarde; Sudipta Ghosh; Abigail W Bigham
Journal:  Proc Natl Acad Sci U S A       Date:  2020-10-27       Impact factor: 11.205
  1 in total

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