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Literature DB >> 33109724

Reply to Liu et al.: The Andean EGLN1 adaptive allele could be a loss of function variant that increases HIF1-α in skeletal muscle.

Tom D Brutsaert¹, Melissa Kiyamu², Gianpietro Elias Revollendo³, Jenna L Isherwood⁴, Frank S Lee⁵, Maria Rivera-Ch², Fabiola Leon-Velarde², Sudipta Ghosh⁶, Abigail W Bigham⁴.

Abstract

Entities: Gene

Mesh：

Year: 2020 PMID： 33109724 PMCID： PMC7703654 DOI： 10.1073/pnas.2012199117

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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8 in total

1. Tibetan and Andean contrasts in adaptation to high-altitude hypoxia.

Authors: C M Beall
Journal: Adv Exp Med Biol Date: 2000 Impact factor: 2.622

2. Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders.

Authors: Brian D Hoit; Nancy D Dalton; Serpil C Erzurum; Daniel Laskowski; Kingman P Strohl; Cynthia M Beall
Journal: J Appl Physiol (1985) Date: 2005-07-14

3. A genetic mechanism for Tibetan high-altitude adaptation.

Authors: Felipe R Lorenzo; Chad Huff; Mikko Myllymäki; Benjamin Olenchock; Sabina Swierczek; Tsewang Tashi; Victor Gordeuk; Tana Wuren; Ge Ri-Li; Donald A McClain; Tahsin M Khan; Parvaiz A Koul; Prasenjit Guchhait; Mohamed E Salama; Jinchuan Xing; Gregg L Semenza; Ella Liberzon; Andrew Wilson; Tatum S Simonson; Lynn B Jorde; William G Kaelin; Peppi Koivunen; Josef T Prchal
Journal: Nat Genet Date: 2014-08-17 Impact factor: 38.330

4. rs1769793 variant reduces EGLN1 expression in skeletal muscle and hippocampus and contributes to high aerobic capacity in hypoxia.

Authors: Guiyou Liu; Wenbo Zhao; Haihua Zhang; Tao Wang; Zhifa Han; Xunming Ji
Journal: Proc Natl Acad Sci U S A Date: 2020-10-27 Impact factor: 11.205

Reply to Liu et al.: The Andean EGLN1 adaptive allele could be a loss of function variant that increases HIF1-α in skeletal muscle.

1. Tibetan and Andean contrasts in adaptation to high-altitude hypoxia.

2. Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders.

3. A genetic mechanism for Tibetan high-altitude adaptation.

4. rs1769793 variant reduces EGLN1 expression in skeletal muscle and hippocampus and contributes to high aerobic capacity in hypoxia.

5. Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing.

6. Low haemoglobin concentration in Tibetan males is associated with greater high-altitude exercise capacity.

7. Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlanders.

8. Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude.