| Literature DB >> 33108271 |
Qinyu Hao1, Xinying Zong1, Qinyu Sun1, Yo-Chuen Lin1, You Jin Song1, Seyedsasan Hashemikhabir2, Rosaline Yc Hsu1, Mohammad Kamran1, Ritu Chaudhary3, Vidisha Tripathi1, Deepak Kumar Singh1, Arindam Chakraborty1, Xiao Ling Li3, Yoon Jung Kim4, Arturo V Orjalo5, Maria Polycarpou-Schwarz6, Branden S Moriarity7, Lisa M Jenkins8, Hans E Johansson5, Yuelin J Zhu9, Sven Diederichs6,10, Anindya Bagchi11, Tae Hoon Kim4, Sarath C Janga2, Ashish Lal3, Supriya G Prasanth1, Kannanganattu V Prasanth1.
Abstract
Cell cycle is a cellular process that is subject to stringent control. In contrast to the wealth of knowledge of proteins controlling the cell cycle, very little is known about the molecular role of lncRNAs (long noncoding RNAs) in cell-cycle progression. By performing genome-wide transcriptome analyses in cell-cycle-synchronized cells, we observed cell-cycle phase-specific induction of >2000 lncRNAs. Further, we demonstrate that an S-phase-upregulated lncRNA, SUNO1, facilitates cell-cycle progression by promoting YAP1-mediated gene expression. SUNO1 facilitates the cell-cycle-specific transcription of WTIP, a positive regulator of YAP1, by promoting the co-activator, DDX5-mediated stabilization of RNA polymerase II on chromatin. Finally, elevated SUNO1 levels are associated with poor cancer prognosis and tumorigenicity, implying its pro-survival role. Thus, we demonstrate the role of a S-phase up-regulated lncRNA in cell-cycle progression via modulating the expression of genes controlling cell proliferation.Entities:
Keywords: HCT116; U2OS; WTIP; cell cycle; chromosomes; gene expression; human cancer cell lines; lncRNA; none
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Year: 2020 PMID： 33108271 PMCID： PMC7591261 DOI： 10.7554/eLife.55102
Source DB: PubMed Journal: Elife ISSN： 2050-084X Impact factor: 8.140