Literature DB >> 33023656

The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression.

Florent Petitprez1,2,3, Sacha Levy4, Cheng-Ming Sun4, Maxime Meylan4,5, Christophe Linhard4, Etienne Becht6, Nabila Elarouci5, David Tavel5, Lubka T Roumenina4, Mira Ayadi5, Catherine Sautès-Fridman4, Wolf H Fridman4, Aurélien de Reyniès7.   

Abstract

Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from transcriptomic data, few are available for mouse studies. We introduce murine Microenvironment Cell Population counter (mMCP-counter), a method based on highly specific transcriptomic markers that accurately quantify 16 immune and stromal murine cell populations. We validated mMCP-counter with flow cytometry data and showed that mMCP-counter outperforms existing methods. We showed that mMCP-counter scores are predictive of response to immune checkpoint blockade in cancer mouse models and identify early immune impacts of Alzheimer's disease.

Entities:  

Keywords:  Alzheimer’s disease; Heterogeneous tissue; Immune checkpoint blockade; Immune composition; Tumor microenvironment

Mesh：

Substances：

Year:  2020        PMID： 33023656      PMCID： PMC7541325          DOI： 10.1186/s13073-020-00783-w

Source DB:  PubMed          Journal:  Genome Med        ISSN： 1756-994X            Impact factor:   11.117


  44 in total

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Authors:  Etienne Becht; Nicolas A Giraldo; Laetitia Lacroix; Bénédicte Buttard; Nabila Elarouci; Florent Petitprez; Janick Selves; Pierre Laurent-Puig; Catherine Sautès-Fridman; Wolf H Fridman; Aurélien de Reyniès
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9.  Reengineering Tumor Microenvironment with Sequential Interleukin Delivery.

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