Literature DB >> 22419253

The immune contexture in human tumours: impact on clinical outcome.

Wolf Herman Fridman1, Franck Pagès, Catherine Sautès-Fridman, Jérôme Galon.   

Abstract

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.

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Year:  2012        PMID： 22419253     DOI： 10.1038/nrc3245

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  174 in total

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