| Literature DB >> 34534350 |
Zexian Zeng1,2, Cheryl J Wong1,3, Lin Yang1, Nofal Ouardaoui1, Dian Li1, Wubing Zhang1,4, Shengqing Gu5,6,1,2, Yi Zhang1,2, Yang Liu1, Xiaoqing Wang5,6,1,2, Jingxin Fu5,7, Liye Zhou5, Boning Zhang5,6,1,2, Sarah Kim7, Kathleen B Yates7,8, Myles Brown5,6, Gordon J Freeman5, Ravindra Uppaluri5,9, Robert Manguso7,8, X Shirley Liu1,2,6.
Abstract
Syngeneic mouse models are tumors derived from murine cancer cells engrafted on genetically identical mouse strains. They are widely used tools for studying tumor immunity and immunotherapy response in the context of a fully functional murine immune system. Large volumes of syngeneic mouse tumor expression profiles under different immunotherapy treatments have been generated, although a lack of systematic collection and analysis makes data reuse challenging. We present Tumor Immune Syngeneic MOuse (TISMO), a database with an extensive collection of syngeneic mouse model profiles with interactive visualization features. TISMO contains 605 in vitro RNA-seq samples from 49 syngeneic cancer cell lines across 23 cancer types, of which 195 underwent cytokine treatment. TISMO also includes 1518 in vivo RNA-seq samples from 68 syngeneic mouse tumor models across 19 cancer types, of which 832 were from immune checkpoint blockade (ICB) studies. We manually annotated the sample metadata, such as cell line, mouse strain, transplantation site, treatment, and response status, and uniformly processed and quality-controlled the RNA-seq data. Besides data download, TISMO provides interactive web interfaces to investigate whether specific gene expression, pathway enrichment, or immune infiltration level is associated with differential immunotherapy response. TISMO is available at http://tismo.cistrome.org.Entities:
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Year: 2022 PMID： 34534350 PMCID： PMC8728303 DOI： 10.1093/nar/gkab804
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971